Associations between plasma and urinary heavy metal concentrations and the risk of prostate cancer DOI Creative Commons
Donatella Coradduzza, Andrea Sanna, Biagio Di Lorenzo

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Prostate cancer is a leading cause of morbidity and mortality worldwide, with incidence rates projected to double between 2020 2040. This growing health challenge highlights the need for improved diagnostic strategies risk assessment tools better understand disease etiology progression. Among environmental factors, heavy metals have been implicated in inflammation carcinogenesis, yet their specific role prostate remains insufficiently explored. novel study analyses relationship metal concentrations plasma urine patients benign prostatic hyperplasia, precancerous lesions cancer. In addition evaluating key clinical parameters, including age, total PSA levels, hemoglobin monocyte/lymphocyte ratio, it aims determine whether contribute progression they can serve as potential biomarkers early diagnosis. Our findings reveal significant differences vanadium antimony plasma, suggesting pathophysiology. Notably, lower are associated an increased PC, while significantly higher PL group. Regression analysis further supports association highlighting copper or therapeutic targets health. The also explores impact lead exposure on risk, revealing concentration PC. These underscore complex interaction emphasizing research elucidate underlying mechanisms explore interventions.

Language: Английский

Comprehensive review of emerging contaminants: Detection technologies, environmental impact, and management strategies DOI Creative Commons
Xingyu Li, Xiaojing Shen, Weiwei Jiang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116420 - 116420

Published: May 2, 2024

Emerging contaminants (ECs) are a diverse group of unregulated pollutants increasingly present in the environment. These contaminants, including pharmaceuticals, personal care products, endocrine disruptors, and industrial chemicals, can enter environment through various pathways persist, accumulating food chain posing risks to ecosystems human health. This comprehensive review examines chemical characteristics, sources, varieties ECs. It critically evaluates current understanding their environmental health impacts, highlighting recent advancements challenges detection analysis. The also assesses existing regulations policies, identifying shortcomings proposing potential enhancements. ECs pose significant wildlife by disrupting animal hormones, causing genetic alterations that diminish diversity resilience, altering soil nutrient dynamics physical Furthermore, increasing health, hormonal disruptions, antibiotic resistance, disruption, neurological effects, carcinogenic other long-term impacts. To address these critical issues, offers recommendations for future research, emphasizing areas requiring further investigation comprehend full implications contaminants. suggests increased funding support development advanced technologies, establishment standardized methods, adoption precautionary regulations, enhanced public awareness education, cross-sectoral collaboration, integration scientific research into policy-making. By implementing solutions, we improve our ability detect, monitor, manage ECs, reducing risks.

Language: Английский

Citations

72
First evidence of microplastics in human ovarian follicular fluid: An emerging threat to female fertility DOI Creative Commons
Luigi Montano,

Salvatore Raimondo,

Marina Piscopo

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117868 - 117868

Published: Feb. 1, 2025

Language: Английский

Citations

10
Sources, distribution, and impacts of emerging contaminants – a critical review on contamination of landfill leachate DOI Creative Commons
Rajesh Kumar Das, Deep Raj

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100602 - 100602

Published: Jan. 1, 2025

Language: Английский

Citations

4
Impact of Bisphenol A and its alternatives on oocyte health: a scoping review DOI Creative Commons
Alexandra E. Peters, Emmalee A. Ford, Shaun D. Roman

et al.

Human Reproduction Update, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Bisphenol A (BPA) is an endocrine disrupting chemical released from plastic materials, including food packaging and dental sealants, persisting in the environment ubiquitously contaminating ecosystems human populations. BPA can elicit array of damaging health effects and, alarmingly, 'BPA-free' alternatives mirror these harmful effects. exposure negatively impact female fertility, both ovary oocytes therein. Such damage diminish reproductive capacity, pregnancy success, offspring health. Despite global government regulations place to indicate 'safe' levels, policies have not considered bisphenols on oocyte

Language: Английский

Citations

13
Simultaneously degradation of various phthalate esters by Rhodococcus sp. AH-ZY2: Strain, omics and enzymatic study DOI

Zhengyu Hou,

Hejuan Pan,

Mengjie Gu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 474, P. 134776 - 134776

Published: May 31, 2024

Language: Английский

Citations

10
First evidence of microplastics in human ovarian follicular fluid: an emerging threat to female fertility DOI Creative Commons
Luigi Montano,

Salvatore Raimondo,

Marina Piscopo

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Plastic pollution is a pressing global issue, with over 400 million tons produced annually and projections of 1.1 billion by 2050. Microplastics (MPs), ranging from 5 mm to 1 µm, are pervasive in the environment. They found air, sea, freshwater, soils, food chains studies show that tiny MPs, smaller than 10 μm, can cross cellular membranes, posing potential health risks through oxidative stress, inflammation, immune dysfunction, neurotoxicity reprotoxicity. In recent years, research has shown microplastics have negative effects on female reproductive systems animals. However, there still lack evidence how accumulation affects human females. This study aimed examine presence ovarian follicular fluid 18 women undergoing assisted treatment whose samples were processed using patented method endorsed nationally internationally. particles <10 µm measured SEM EDX detection. Preventive measures taken avoid contamination during process. (dimensions µm) detected 14 out fluid, an average 2191 p/ml (0 - 7181p/ml) mean diameter MPs 4.48 (3.18-5.54 µm). A significant correlation was between microplastic concentration FSH (p-value <0.05), as well weak BMI, age Estradiol. There no fertilization outcomes, miscarriages, or live birth. first provide for microplastics’ treatment, representing threat function. Figure

Language: Английский

Citations

9
Heavy metals and prostate cancer: a new study with new findings DOI Creative Commons
Donatella Coradduzza, Antonella Congiargiu, Andrea Sanna

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Heavy metals influence the development of several health conditions, including inflammation and cancer. This study investigates relationship between heavy metal concentrations in plasma urine, presence benign prostatic hyperplasia (BPH), precancerous lesions (PL), prostate cancer (PC). The age, total PSA levels, hemoglobin concentrations, monocyte-to-lymphocyte ratio (MLR) is also analyzed across three groups: BPH, PL, PC. Our findings reveal significant differences vanadium antimony plasma, suggesting a potential role disease pathophysiology. Notably, lower are associated with an increased risk PC, while significantly higher PL group. Regression analysis further supports association highlighting copper as biomarkers or therapeutic targets for health. explores impact lead exposure on risk, revealing urine concentration These underscore complex interaction emphasizing need research to elucidate underlying mechanisms explore interventions.

Language: Английский

Citations

1
Perinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice. DOI
Brigitta Bonaldo, Antonino Casile,

Martina Bettarelli

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120888 - 120888

Published: Jan. 1, 2025

Language: Английский

Citations

1
Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms DOI
Nitin Bhardwaj,

Sumit Rajaura,

Ashutosh Singh

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108909 - 108909

Published: April 1, 2025

Language: Английский

Citations

1
AgNPs/CuNPs/Bragg-PSi substrate subjected to thermal annealing in high-sensitivity detection on crystal violets and diphenyl phthalate DOI Creative Commons
Bowen Sun, Peng Li, Shuguo Yu

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(1), P. 388 - 397

Published: Jan. 1, 2025

Study creates optimized AgNPs/CuNPs/Bragg-PSi SERS substrate for detecting low-concentration analytes like crystal violet and diphenyl phthalate. Best performance at 0.75 M CuNO 3 soak 180 °C annealing, promising analytical applications.

Language: Английский

Citations

0