Environment International,
Journal Year:
2023,
Volume and Issue:
173, P. 107834 - 107834
Published: Feb. 28, 2023
Prenatal
exposure
to
certain
organic
chemicals
like
pesticides
and
phenols
has
been
lifelong
associated
with
birth
outcomes
health
disorders.
Many
personal
care
product
(PCP)
ingredients
have
similar
properties
or
structures
those
chemicals.
Previous
studies
documented
the
occurrence
of
UV
filters
(UVFs)
paraben
preservatives
(PBs)
in
placenta,
but
observational
concerning
PCPs
foetal
are
particularly
scarce.
Thus,
this
work
aimed
assess
presence
a
wide
range
using
target
suspect
screening
umbilical
cord
blood
new
born
babies
evaluate
their
potential
transfer
fetus.
To
do
so,
we
analysed
69
plasma
samples
from
mother-child
cohort
Barcelona
(Spain).
We
quantified
8
benzophenone-type
UVFs
metabolites,
4
PBs
validated
analytical
methodologies
based
on
liquid
chromatography-tandem
mass
spectrometry
(HPLC-MS/MS).
Then,
screened
for
additional
3246
substances
high-resolution
(HRMS)
advanced
analysis
strategies.
Six
three
parabens
were
detected
frequencies
between
1.4%
17.4%
concentrations
up
53.3
ng/mL
(benzophenone-2).
Thirteen
tentatively
identified
screening,
ten
further
confirmed
corresponding
standards.
Among
them,
found
solvent
N-methyl-2-pyrrolidone,
chelating
agent
8-hydroxyquinoline,
antioxidant
2,2'-methylenebis(4-methyl-6-tert-butylphenol),
which
demonstrated
display
reproductive
toxicity.
demonstrates
mother-fetus
through
placental
barrier
prenatal
these
chemicals,
may
lead
adverse
effects
early
stages
fetal
development.
Considering
small
used
study,
reported
results
should
be
interpreted
as
preliminary
reference
background
levels
Further
research
is
needed
determine
long-term
consequences
Separations,
Journal Year:
2024,
Volume and Issue:
11(1), P. 30 - 30
Published: Jan. 12, 2024
Sunscreens
are
topical
preparations
containing
one
or
more
compounds
that
protect
humans
from
ultraviolet
(UV)
light.
This
review
focuses
on
analytical
methods,
particularly
liquid
chromatography,
with
the
aim
of
identifying
and
determining
UV
filters
(UVFs)
in
environmental
marine
biota
matrices.
A
literature
was
conducted
using
NIH
(PubMed
Medline),
FDA
EPA
databases,
Google
Scholar,
federal
regulations.
retrospective
is
focused
last
five
years.
UVF
quantification
biological
matrices
showed
a
wide
array
methods
where
chromatography
predominant.
The
scientific
identified
large
variety
methodologies
compared
this
to
evaluate
better
results
terms
limits
possibility
identify
as
many
analytes
possible
simultaneously.
Environmental Science and Pollution Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
There
is
an
ongoing
debate
regarding
the
role
of
microplastics
(MPs)
in
enhancing
effects
various
chemical
compounds,
highlighting
need
for
more
detailed
analyses.
In
this
study,
neonates
water
flea
(Daphnia
magna)
were
exposed
to
polystyrene
MPs
(PS-MPs;
3
µm;
exposure
concentration,
1.25
mg/L),
a
mixture
seven
organic
UV-filters
(avobenzone,
ethylhexyl
triazone,
homosalate,
iscotrizinol,
octinoxate,
octisalate,
and
octocrylene;
each
at
low
environmental
concentration
200
ng/L),
or
combination
both
pollutants
3,
7,
21
days.
Results
showed
that
PS-MPs
alone
decreased
body
size
daphnids,
while
all
treatments
increased
heart
rate
by
end
21-day
exposure.
On
days
21,
+
reduced
swimming
speed
total
distance
travelled.
Additionally,
time
first
egg
production,
but
number
number,
maximum
neonate
during
treatment.
Similarly,
combined
production
number.
All
multixenobiotic
resistance
activity
on
only
elevated
CYP450
day
3.
GST
early
no
effect
21.
CAT
was
also
affected
time-dependent
manner.
These
findings
demonstrate
chronic
UV-filters,
applied
individually
moderately
impacts
development,
rate,
D.
magna,
significantly
altering
reproduction
key
cellular
functions
such
as
membrane
transport
activity,
metabolism,
antioxidant
defense.
Co-exposure
did
not
reveal
clear
pattern
synergism
antagonism,
suggesting
joint
toxicity
risks
these
xenobiotics
typically
emerge
concentrations
higher
than
levels.
Future
studies
should
explore
potential
interactions
thoroughly
assess
transgenerational
defense
pathways.
Frontiers in Environmental Chemistry,
Journal Year:
2025,
Volume and Issue:
6
Published: March 3, 2025
Treated
sewage
sludge,
or
biosolids,
are
used
worldwide
to
improve
soil
quality
and
fertility
due
their
high
organic
matter
content
micro-
macronutrients.
However,
biosolids
also
introduce
contaminants
into
the
environment.
This
review
assessed
recent
publications
on
occurrence,
environmental
fate,
transportation
mechanisms
of
419
emerging
concern
(CEC)
across
four
matrices:
soils,
dust.
Among
these,
229
CECs
were
positively
detected
at
least
once.
The
focuses
various
CECs,
including
18
therapeutical
classes
pharmaceutical
products,
personal
care
products
(parabens
chlorophenolic
antimicrobials),
hormones,
plastic-related
compounds
(bisphenols
phthalates),
rubber
antioxidants
(substituted
diphenylamines
para-phenylenediamines),
neonicotinoid
insecticides.
Phthalates
dominate
biosolid
composition,
accounting
for
over
97%
total
weight
investigated,
followed
by
pharmaceuticals
(1.87%),
(0.57%),
hormones
(0.09%),
(0.07%),
bisphenols
(0.05%).
50
most
prevalent
include
phthalates
[e.g.,
di
(2-ethylhexyl)
phthalate-DEHP,
butyl
benzyl
phthalate-BBzP],
antifungals
(e.g.,
miconazole-MCZ,
ketoconazole-KTZ),
antimicrobials
triclocarban-TCC,
triclosan-TCS),
fluoroquinolone
antibiotics
ofloxacin-OFL,
ciprofloxacin-CPF),
cardiovascular
medications
telmisartan-TMS,
propafenone-PPF),
analgesics
salicylic
acid-SA,
naproxen-NPX),
mestranol-EEME,
progesterone-P),
antidepressants
sertraline-SRT,
amitriptyline-AMT),
lipid
regulators
fenofibrate-FNF).
Analytical
techniques
like
matrix-assisted
laser
desorption/ionization
mass
spectrometry
imaging
(MALDI-MSI)
have
emerged
as
a
valuable
tool
qualitative
analysis,
allowing
identifying
in
biosolids.
fate
transport
dynamics
studied
influenced
physicochemical
properties
(water
solubility,
volatility,
degradation
time,
sorption
capacity,
bioaccumulation
potential)
conditions
(temperature,
pH,
moisture
content).
Furthermore,
characteristics,
such
matter,
microbial
activity,
play
key
roles
adsorption,
degradation,
persistence
environments.
Additionally,
wastewater
treatment
processes
impact
transformation
removal
affecting
partitioning
between
treated
effluents
sludge.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116053 - 116053
Published: Feb. 1, 2024
Organic
UV
filters,
which
are
often
found
in
the
environment,
have
been
focus
of
much
public
health
concern.
2-ethylhexyl-4-methoxycinnamate
(EHMC)
is
one
most
common
organic
filters
present
environment.
However,
few
studies
investigated
its
developmental
neurotoxic
(DNT)
effects
and
underlying
molecular
mechanisms.
In
study,
zebrafish
embryos
were
exposed
to
low
concentration
EHMC
(0,
0.01,
0.1,
1
mg/L)
static
water
starting
from
6
h
post-fertilization
(hpf).
Results
showed
that
exposure
caused
a
reduction
somite
count
at
13
hpf,
diminishment
head-trunk
angle
30
delay
hatching
48
decrease
head
depth
length
both
hpf.
Additionally,
led
abnormal
motor
behaviors
various
stages
including
altered
spontaneous
movement
23
24
decreased
touch
response
Consistent
with
these
morphological
changes
behavior
deficits,
inhibited
axonal
growth
primary
neurons
yielded
subtle
muscle
fiber
suggesting
functional
relevance
structural
changes.
Moreover,
induced
excessive
cell
apoptosis
spinal
cord
regions,
increased
production
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA),
reduced
level
glutathione
(GSH).
Defects
lateral
line
system
neuromasts
also
observed,
but
no
deformity
blood
vessels
was
seen
developing
zebrafish.
Abnormal
expression
growth-related
genes
(gap43,
mbp,
shha,
α1-tubulin)
apoptosis-related
(bax/bcl-2
caspase-3)
revealed
potential
mechanisms
regarding
defective
aberrant
phenotype.
summary,
our
findings
indicate
neurotoxicity
zebrafish,
making
it
essential
assess
risks
provide
warnings
exposure.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(2), P. 125 - 125
Published: Feb. 2, 2024
Plastic
additives
that
maintain
integrity
have
been
extensively
studied
for
potential
toxicity
to
fish;
however,
chemicals
protect
polymers
from
(artificial)
UV
degradation
are
less
studied.
Benzotriazole
stabilizers
(BUVSs)
the
most
widely
used
in
plastics
and
often
sunscreens,
cosmetics,
paint,
food
packaging.
BUVSs
can
negatively
affect
aquatic
wildlife
when
released
into
environment
via
plastic
degradation.
In
this
review,
we
summarize
distribution
of
globally
discuss
neurotoxicological
endpoints
measured
fish
understand
how
these
neurological
health
teleost
fishes.
detected
environments
at
concentrations
ranging
0.05
up
99,200
ng/L.
Studies
show
behavioral
responses
acetylcholinesterase
activity,
indicators
neurotoxicity.
Our
computational
analysis
using
transcriptome
data
suggests
certain
pathways
associated
with
neurodegeneration
responsive
exposure
BUVSs,
like
“Complement
Activation
Alzheimer’s
Disease”.
Based
on
our
identify
some
research
needs
future
investigations:
(1)
molecular
studies
central
nervous
system
define
precise
mechanisms
neurotoxicity;
(2)
a
wider
range
tests
assessing
aberrant
behaviors
given
activity
larval
zebrafish;
(3)
histopathology
accompany
biochemical
analyses.
These
expected
enhance
understanding
neurotoxicity
benzotriazoles
other
additives.
