Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 24, 2024
Personal
care
products
(PCPs)
contain
a
number
of
endocrine-disrupting
chemicals
(EDCs)
that
could
potentially
affect
the
reproductive
function
in
women
childbearing
age.
However,
studies
focused
on
effects
PCPs
use
outcomes
are
very
limited.
The
current
study
aimed
to
explore
relationships
between
patterns
and
undergoing
vitro
fertilization/intracytoplasmic
sperm
injection
(IVF/ICSI)
treatment.
A
total
1500
from
Tongji
Reproductive
Environmental
(TREE)
December
2018
January
2020
were
included
this
study.
Participants
provided
characteristics
within
previous
three
months.
Retrieved
oocyte
number,
mature
two
distinct
pronuclei
(2PN)
zygote
fertilization
rate,
cleavage
blastocyst
formation
implantation,
clinical
pregnancy,
miscarriage,
live
birth
followed
up
as
endpoints.
Generalized
linear
regression
model
was
utilized
assess
associations
various
categories
endpoints
IVF/ICSI.
After
adjusting
for
relevant
covariates,
who
used
skin
≥14
times
per
week
had
reduction
22.4%
maturation
rate
(95%
CI:
-39.2%,
-1.6%)
compared
participants
did
not
products.
transferring
fresh
embryos,
cosmetics
1-2
(adjusted
OR
=
2.2,
95%
1.0,
4.8)
or
3-7
2.5,
1.2,
5.2)
higher
possibility
miscarriage
than
those
cosmetics.
There
negative
association
gel
soap
among
aged
<
30
years
old
(P
interaction
0.01).
Among
with
BMI
≥
24
kg/m2,
negatively
associated
0.04),
while
0.001).
Our
findings
suggest
age
have
potential
adverse
impact
IVF/ICSI
outcomes,
particularly
cosmetic
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
478, P. 135444 - 135444
Published: Aug. 6, 2024
Pharmaceuticals
and
personal
care
products
(PPCPs)
exhibit
varying
biodegradability
during
the
acidogenic
methanogenic
phases
of
anaerobic
digestion.
However,
there
is
limited
information
regarding
end
generated
these
processes.
This
work
investigates
biotransformation
(BTPs)
in
a
two-phase
(TP)
acidogenic-methanogenic
(Ac-Mt)
bioreactor
using
advanced
suspect
nontarget
strategies.
Fourteen
BTPs
were
confidently
identified
from
ten
parent
PPCPs
including
carbamazepine
(CBZ),
naproxen
(NPX),
diclofenac
(DCF),
ibuprofen
(IBU),
acetaminophen
(ACT),
metoprolol
(MTP),
sulfamethoxazole
(SMX),
ciprofloxacin
(CIP),
methylparaben
(MPB)
propylparaben
(PPB).
These
linked
with
oxidation
reactions
such
as
hydroxylation,
demethylation
epoxidation.
Their
generation
was
related
to
organic
acid
production,
since
all
metabolites
detected
acidogenesis,
some
being
subsequently
consumed
methanogenesis,
e.g.,
aminothiophenol
kynurenic
acid.
Another
group
showed
increased
concentrations
under
conditions,
hydroxy-diclofenac
epoxy-carbamazepine.
The
most
high
removal
efficiencies
(>
90
%)
–
SMX,
CIP,
NPX,
MTP,
ACT,
MPB,
PPB,
while
DCF,
CBZ
IBU
demonstrated
higher
persistence
-
DCF
(42
%);
(40
%),
(47
%).
phase
separation
digestion
provided
deeper
understanding
pathways
PPCPs,
addition
enhancing
persistent
compounds,
i.e.,
IBU.
Chemosphere,
Journal Year:
2024,
Volume and Issue:
351, P. 141221 - 141221
Published: Jan. 13, 2024
Suspect
and
non-target
screening
(SNTS)
methods
are
being
promoted
in
order
to
decode
the
human
exposome
since
a
wide
chemical
space
can
be
analysed
diversity
of
biofluids.
However,
SNTS
approaches
exposomics
field
infra-studied
comparison
environmental
or
food
monitoring
studies.
In
this
work,
comprehensive
suspect
workflow
was
developed
annotate
exposome-related
xenobiotics
phase
II
metabolites
diverse
Precisely,
urine,
breast
milk,
saliva
ovarian
follicular
fluid
were
employed
as
samples
by
means
ultra-high
performance
liquid
chromatography
coupled
with
high
resolution
tandem
mass
spectrometry
(UHPLC-HRMS/MS).
To
automate
workflow,
"peak
rating"
parameter
implemented
Compound
Discoverer
3.3.2
optimized
avoid
time-consuming
manual
revision
chromatographic
peaks.
addition,
presence
endogenous
molecules
that
might
interfere
annotation
carefully
studied
employment
inclusion
exclusion
lists.
evaluate
limits
identification
(LOIs)
type
I
errors
(i.e.,
false
positives
negatives,
respectively)
calculated
both
standard
solutions
spiked
biofluids
using
161
22
metabolites.
For
80.3
%
suspects,
LOIs
below
15
ng/mL
achieved.
terms
errors,
only
two
cases
identified
standards
samples.
Regarding
7.7
accounted
increased
17.4
real
Lastly,
use
an
list
for
endogens
favoured
it
avoided
18.7
potential
while
caused
7.2
despite
making
less
time-consuming.
Chinese Journal of Chromatography,
Journal Year:
2024,
Volume and Issue:
42(2), P. 109 - 119
Published: Feb. 1, 2024
The
occurrence
and
development
of
human
diseases
are
influenced
by
both
genetic
environmental
factors.
Research
models
that
describe
disease
only
from
the
perspective
genetics
present
certain
limitations.
In
recent
years,
effects
environment
factors
on
have
attracted
extensive
attentions.
Exposomics
focuses
measurement
all
exposure
in
an
individual's
life
how
these
related
to
development.
provides
new
ideas
promote
studies
relationship
between
health
Environmental
exposures
characterized
with
different
physical
chemical
properties,
as
well
very
low
concentrations
vivo,
which
contribute
great
challenges
comprehensive
residues
body.
Chromatography-mass
spectrometry-based
technologies
combine
high-efficiency
separation
ability
chromatography
high
resolution
sensitive
detection
characteristics
mass
spectrometry;
combination
techniques
can
achieve
high-coverage,
high-throughput,
exposures,
thus
providing
a
powerful
tool
for
measuring
exposures.
Exposomics-analysis
methods
based
chromatography-mass
spectrometry
mainly
include
targeted
quantitative
analysis,
suspect
screening,
non-targeted
screening.
To
explore
diseases,
researchers
developed
research
paradigms,
including
exposome
wide
association
study,
mixed-exposure
exposomics
multi-omics
(genome,
transcriptome,
proteome,
metabolome)-association
so
on.
emergence
has
brought
about
unprecedented
developments
studies.
this
manuscript,
analytical
spectrometry,
their
relevant
prospects
reviewed.
TrAC Trends in Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
180, P. 117903 - 117903
Published: Aug. 9, 2024
Exposure
to
organic
compounds
during
early-life
stages
can
disrupt
human
development
and
increase
susceptibility
adverse
health
outcomes
later
in
life.
Despite
evidence
of
these
impacts,
research
has
primarily
focused
on
targeted
analyses,
missing
the
complex
nature
exposures.
Comprehensive
approaches
are
needed
better
characterize
mixtures.
Recent
advances
high-resolution
mass
spectrometry
computational
science
have
enabled
comprehensive
analysis
numerous
chemicals
through
wide-scope
screening
approaches,
yet
their
application
exposome
studies
is
still
limited.
This
review
critically
examines
from
past
decade
using
investigate
chemical
exposome,
emphasizing
compounds.
It
evaluates
each
step
analytical
workflow,
including
sample
collection,
preparation,
analysis,
data
processing,
concludes
with
recommendations
for
future
improve
understanding
its
implications.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12373 - 12373
Published: Nov. 18, 2024
A
total
of
16
organic
sunscreens
and
over
160
products
their
degradation
in
biotic
abiotic
conditions
were
investigated
the
context
safety
during
pregnancy.
Drug-likeness
ability
studied
compounds
to
be
absorbed
from
gastrointestinal
tract
cross
human
placenta
predicted
silico
using
SwissADME
software
(for
drug-likeness
oral
absorption)
multiple
linear
regression
"ARKA"
models
permeability
expressed
as
fetus-to-mother
blood
concentration
state
equilibrium),
with
latter
outperforming
MLR
models.
It
was
established
that
most
can
tract.
The
(expressed
a
binary
descriptor,
