The triangular relationship of physical activity, depression, and inflammatory markers: A large cross-sectional analysis with NHANES data DOI Creative Commons
Xinrong Guo, Yuan Le

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 367, P. 589 - 597

Published: Sept. 3, 2024

Depression is a major public health problem worldwide and closely related with systemic inflammatory responses. Additionly, physical activity (PA) thought to be associated lower levels of depression markers. This study aimed elucidate the complex interactions between PA, depression, Based on National Health Nutrition Examination Survey (NHANES), various logistic regression were applied analyze pairwise correlations among three. Restrictive cubic splines constructed explore nonlinear relationship PA depression. Mediation models used identify mediating role The findings revealed positive link marker, whereas was inversely correlated both marker Particularly, we noticed greatest reduction in risk when level 1200 1722 MET-min/week. Besides, demonstrated that markers mediate potential effects inactivity ranging from 1.72 % 6.25 %. In conclusion, appear protect against which may play role. Moreover, determined optimal dosage minimize likelihood thereby offering valuable guidance for managing

Language: Английский

Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: The mediating role of serum albumin DOI Creative Commons
Yan Wang, Jingwen Zhang, Jiaxian Zhang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171742 - 171742

Published: March 15, 2024

No study has examined the association between per- and polyfluoroalkyl substances (PFAS) exposure chronic obstructive pulmonary disease (COPD) risk. This aims to explore this relationship. enrolled 4541 individuals who had unavailable data on PFAS, COPD, covariates from NHANES 2007–2018. Serum PFAS including perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS) were analyzed, because of high detective rates. Considering skew distribution levels, natural logarithm-transformed (Ln-PFAS) was used. Logistic regression analysis, restricted cubic spline (RCS), weighted quantile sum (WQS) performed single, nonlinear, mixed effects. A mediating analysis used evaluate mediated effects albumin. Individuals with COPD higher levels PFHxS, PFNA, PFOA, PFOS compared those without COPD. Ln-PFNA (OR males: 1.92, 95 % CI:1.31 2.80, P: <0.001; OR females: 1.07, CI: 0.81 1.40, 0.636) ln-PFOA 2.17, CI:1.38 3.41, 1.49, 1.08 2.05, 0.016) associated risk especially in males. The interaction PFNA sex significant (P interaction: <0.001). RCS curve demonstrated nonlinear relationship nonlinear:0.001), ln-PFNA nonlinear:0.045), WQS showed correlated males (OR: 1.44, CI:1.18 1.75, Albumin PFOA (mediated proportion: −17.94 %). concludes are linked a males, serum albumin plays role Thess findings beneficial for prevention Further studies required potential mechanisms.

Language: Английский

Citations

14
Dietary Copper Intake and Risk of Parkinson’s Disease: a Cross-sectional Study DOI Creative Commons
Zhaohao Zeng, Yanmei Cen,

Lijiao Xiong

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(3), P. 955 - 964

Published: July 18, 2023

Copper is an essential trace element for the human body. The epidemiological evidence association of dietary intake copper with risk Parkinson's disease (PD) limited. We conducted evaluation cross-sectional data gathered from National Health and Nutrition Examination Surveys spanning 2007 to 2018, which comprised a total 17,948 participants. To discern distinct characteristics participants, we performed univariate analysis utilized 1:2 ratio propensity score matching method minimize effects selection bias. employed weighted as well three multivariate logistic regression models both prior following matching, aim examining between PD risk. Finally, used restricted cubic spline (RCS) methodology in order investigate possible non-linear relationships. Furthermore, subgroup was undertaken elicit further understanding concerning PD. A negative correlation resulted models, matching. Our findings demonstrate that there nonlinear, dose-dependent relationship PD, according our RCS analysis. In analysis, identified important protective factor individuals who were non-Hispanic White, unmarried, had completed higher education. Dietary associated Supplementation may have potentially beneficial effects.

Language: Английский

Citations

23
An advanced ratiometric molecularly imprinted sensor based on metal ion reoxidation for indirect and ultrasensitive glyphosate detection in fruit DOI
Xiaoyu Su,

Kaiyi Zheng,

Xiaoyu Tian

et al.

Food Chemistry, Journal Year: 2023, Volume and Issue: 429, P. 136927 - 136927

Published: July 18, 2023

Language: Английский

Citations

21
Potential lethality of organochlorine pesticides: Inducing fatality through inflammatory responses in the organism DOI Creative Commons

Jiaxing Tan,

Mengkai Ma,

Xinyue Shen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116508 - 116508

Published: May 29, 2024

Organochlorine pesticides, with their environmental persistence and bioaccumulation potential, have gained significant attention. This study explores the impact of organochlorine pesticides on mortality chronic diseases, investigates link to inflammatory states, examines role anti-inflammatory diets in mitigating adverse reactions these pesticides. study, 2,847 participants, used gas chromatography mass spectrometry measure pesticide exposure NHANES data. Conventional statistical methodologies, encompassing survival curves, Cox proportional hazards regression, regression analysis, restricted quadratic spline were employed investigate association between mortality, ailments, inflammation. Furthermore, machine learning techniques, comprising RF, AdaBoost, Extra-Trees, LightGBM, BPNN, leveraged evaluate disease prognostication. significantly positively correlated increased (p<0.05). Additionally, pollutants linked incidence diseases such as kidney disease, diabetes, hypertension (p< 0.05). Our utilizing various models, also showed a notable increase Area Under Curve when incorporating indicators into model opposed excluding them. strong correlations observed serum c-reactive protein (CRP) CRP albumin ratio (CAR) concentrations substances, demonstrating pro-inflammatory effects at specific concentrations. Interestingly, cutting down dietary inflammation through changes diet effectively reduced risk death high levels, but effect was less noticeable low moderate levels. Exposure higher likely due an prevalence diseases. In this context, played crucial role, adopting associated

Language: Английский

Citations

8
Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults DOI
Yinqiao Dong,

Wei Xu,

Shiping Liu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174748 - 174748

Published: Oct. 1, 2024

Language: Английский

Citations

8
Self-driven photoelectrochemical sensor based on Z-type perovskite heterojunction for profenofos detection in milk and cabbage DOI
Wenming Yang,

Mingyang Gao,

Yi Zhang

et al.

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 106738 - 106738

Published: Sept. 1, 2024

Language: Английский

Citations

8
Xinnaoxin capsule alleviates neuropathological changes and cognitive deficits in Alzheimer’s disease mouse model induced by D-galactose and aluminum chloride via reducing neuroinflammation and protecting synaptic proteins DOI
Xipei Wu,

X. Qiu,

Shirui Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119323 - 119323

Published: Jan. 1, 2025

Language: Английский

Citations

1
Association between organophosphorus insecticides exposure and the prevalence of sleep problems in the US adults: An analysis based on the NHANES 2007–2018 DOI Creative Commons
Lu Han, Qi Wang

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 255, P. 114803 - 114803

Published: March 22, 2023

The aim of this study was to evaluate the association between organophosphorus pesticides (OPPs) exposure and sleep problems. In study, data from 6295 participants aged 18 years or older were collected National Health Nutrition Examination Survey (NHANES). dialkyl phosphate compounds (DAPs) metabolites, OPPs biomarker, examined using solid phase extraction-high coupled with isotope dilution-ultrahigh performance liquid chromatography-tandem mass spectrometry. Data on short duration (SSD), self-reported trouble sleeping disorder database. Weighted generalized logistic model, weighted quantile sum (WQS) quantile-based g calculation (QGC) methods used for analyzing data. prevalence SSD, in 28.91 % (1814/6274), 25.31 (1593/6294), 9.05 (289/3195), respectively. After confounding factors adjustments, SDD high log-transformed DETP, DMTP, DEDTP, DMDTP 1.19 times (OR: 1.11–1.28, P < 0.001), 1.09 1.03–1.15, = 0.003), 1.26 1.17–1.37, 0.0001), 1.10 1.04–1.17, 0.003) than low showed, A non-linear relationship noted SSD urinary concentration DEP (P nonlinearity DMP DMTP 0.006), 0.001). WQS results showed that 1.28 (95 CI: 1.17–1.40, 0.001) higher co-exposure those co-exposure, DEDTP having enormous weights (0.50). QGC also revealed a significant positive DAPs 1.08, 95 CI:1.02–1.16, 0.01) DETP most weight (0.44). As self-report disorder, only detected it positively associated all adjusted 1.17; 1.07–1.29, However, have not sleeping. Besides, there no disorder. indicated levels single mixture DAP, indicating exposure, an increased general adults, which has implications preventing pollution protecting health.

Language: Английский

Citations

13
A novel self-enhanced electrochemiluminescent aptamer sensor based on ternary nanocomposite PEI/RuSi-MWCNTs for the detection of profenofos residues in vegetables DOI Creative Commons

Zhenying He,

Haifang Wang, Wenzheng Liu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e25167 - e25167

Published: Jan. 26, 2024

In this work, a novel ternary nanocomposite of PEI/RuSi-MWCNTs was designed and synthesized for the first time, which an ultrasensitive self-enhanced electrochemiluminescent (ECL) aptasensor developed detection profenofos residues in vegetables. The complex PEI-Ru (II) enhanced emission stability ECL, multi-walled carbon nanotubes (MWCNTs) acted as excellent carrier signal amplification. were characterized by scanning electron microscope (SEM), transmission (TEM) energy dispersive spectrometer (EDS). incorporation gold nanoparticles (AuNPs) improved performance sensor provided platform immobilization aptamer. results experiment showed that presence significantly suppressed electrochemiluminescence intensity sensor. sensitivity aptamer range 1 × 10−2 to 103 ng/mL. Under optimal conditions, limit (LOD) 1.482 10−3 had stability, reproducibility specificity. recoveries ranged from 92.29 % 106.47 real sample tests.

Language: Английский

Citations

5
Agricultural activities and risk of treatment for depressive disorders among the entire French agricultural workforce: the TRACTOR project, a nationwide retrospective cohort study DOI Creative Commons
Pascal Petit, Gérald Gandon,

Marc Dubuc

et al.

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 31, P. 100674 - 100674

Published: June 26, 2023

Although depression is a major issue among farming population, to date, there have been few studies on specific agricultural activities. We aimed investigate whether, the entire French farm manager (FM) workforce, certain activities are more strongly associated with than others.This nationwide retrospective cohort study used data from an administrative health database available TRACTOR project. This pertains workforce (overseas workers not included). Data were analyzed January 2021 December 2022. All FMs that worked at least once over period 2002-2016 included. The outcome measure was association between 26 and risk of measured as hazard ratios (HRs) after adjusting for age, sex, pre-existing medical comorbidities. time first insurance declaration, or antidepressant prescription claim underlying timescale. For each activity, reference/control group included all never performed considered activity 2002 2016, while exposed 2016. Four sensitivity analyses conducted test hypotheses, address potential sources bias.There 84,507 (7.76%; 28.2 cases per 1000 person-years) 1,088,561 (mean age 46.6 [SD 14.1]). Compared other activities, dairy (HR = 1.37, 95% confidence interval: 1.32-1.42), cow 1.53 [1.47-1.59]), poultry rabbit 1.37 [1.27-1.50]), mixed 1.30 [1.24-1.36]) depression. Sex differences observed, most time, risks higher females males.Agricultural identified. These findings do represent crucial step road implement effective preventive measures against determine where additional resources should be allocated screen depression, along intervention.MIAI@Grenoble Alpes, Mutualité Sociale Agricole.

Language: Английский

Citations

11