Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
282, P. 116689 - 116689
Published: July 15, 2024
The
recent
acceleration
of
industrialization
and
urbanization
has
brought
significant
attention
to
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine
quinone
(6-PPDQ),
an
emerging
environmental
pollutant
from
tire
wear,
due
its
long-term
effects
on
the
environment
organisms.
Recent
studies
suggest
that
6-PPDQ
can
disrupt
neurotransmitter
synthesis
release,
impact
receptor
function,
alter
signaling
pathways,
potentially
causing
oxidative
stress,
inflammation,
apoptosis.
This
review
investigates
potential
neurotoxic
prolonged
exposure,
mechanisms
underlying
cytotoxicity,
associated
health
risks.
We
emphasize
need
for
future
research,
including
precise
exposure
assessments,
identification
individual
differences,
development
risk
assessments
intervention
strategies.
article
provides
a
comprehensive
overview
6-PPDQ's
behavior,
impact,
neurotoxicity
in
environment,
highlighting
key
areas
challenges
research.
Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
348, P. 123835 - 123835
Published: March 21, 2024
Plastic
pollution,
including
micro-
and
nanoplastics,
is
a
growing
concern.
Tyre-wear
particles
(TWPs)
are
the
second
largest
source
of
microplastics
in
ocean
following
abrasion
synthetic
fibres.
In
addition
to
themselves,
TWPs
contain
many
harmful
chemicals,
6PPD.
This
chemical
reacts
with
atmospheric
ozone
forms
toxic
compound
6PPD-quinone
(6PPDq),
which
poses
danger
aquatic
life.
There
knowledge
gap
understanding
risks
associated
combined
toxicity
nanoplastics
(NPs)
6PPDq.
The
present
study
aimed
investigate
NPs
6PPDq
on
adult
zebrafish
using
phenotypic
(behaviour,
histology)
transcriptomic
endpoints.
Zebrafish
were
exposed
four
treatments:
control
(contaminant-free),
50
μg/L
6PPDq,
3
mg/L
polystyrene
(PS)-NPs,
combination
PS-NPs.
We
did
not
observe
locomotory
dysregulation
NPs.
However,
we
found
significant
hyperlocomotion
this
effect
was
even
more
substantial
after
co-exposure
explores
molecular
mechanisms
behind
these
effects,
identifying
genes
neurotransmitters
fatty
acid
metabolism
that
dysregulated
by
co-exposure.
Transcriptomic
analysis
further
showed
both
PS-NPs
impacted
cellular
processes
sterol
biosynthesis,
cholesterol
metabolism,
muscle
tissue
development.
effects
stronger
co-exposed
zebrafish,
indicating
heightened
risk
integrity
mitochondrial
dysfunction.
These
results
highlight
significance
mixture
when
studying
chemicals
like
Toxics,
Journal Year:
2024,
Volume and Issue:
12(6), P. 420 - 420
Published: June 7, 2024
Transgenerational
nanoplastic
toxicity
could
be
detected
in
Caenorhabditis
elegans
after
exposure
at
the
parental
generation
(P0-G);
however,
underlying
mechanisms
remain
largely
unclear.
We
aimed
to
examine
role
of
germline
nuclear
hormone
receptors
(NHRs)
controlling
transgenerational
polystyrene
nanoparticles
(PS-NPs)
based
on
gene
expression
screening
and
functional
analysis.
Among
NHR
genes,
daf-12,
nhr-14,
nhr-47
expressions
were
increased
nhr-12
was
decreased
by
PS-NPs
(1
10
μg/L).
alterations
these
four
genes
also
induced
RNAi
caused
resistance,
whereas
conferred
susceptibility
PS-NP
toxicity.
After
exposure,
ins-3,
daf-28,
ins-39
encoding
insulin
ligands,
efn-3
Ephrin
ligand,
lin-44
Wnt
as
well
their
receptor
(daf-2,
vab-1,
and/or
mig-1),
dysregulated
nhr-47,
nhr-12.
Therefore,
alteration
certain
NHRs
mediate
induction
affecting
secreted
ligands
offspring
exposed
organisms.
