Prenatal exposure to polybrominated diphenyl ether (PBDE) and child neurodevelopment: The role of breastfeeding duration

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 921, P. 171202 - 171202

Published: Feb. 24, 2024

Language: Английский

---

Enhanced electrochemical oxidation and machine learning-assisted sensing of tetrabromobisphenol A using activated carbon facilitated CoWO4 heterostructures

Materials Science and Engineering B, Journal Year: 2024, Volume and Issue: 308, P. 117546 - 117546

Published: July 10, 2024

Language: Английский

---

Update of the risk assessment of brominated phenols and their derivatives in food

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(10)

Published: Oct. 1, 2024

Abstract The European Commission asked EFSA to update its 2012 risk assessment on brominated phenols and their derivatives in food, focusing five bromophenols one derivative: 2,4,6‐tribromophenol (2,4,6‐TBP), 2,4‐dibromophenol (2,4‐DBP), 4‐bromophenol (4‐BP), 2,6‐dibromophenol (2,6‐DBP), tetrabrominated bisphenol S (TBBPS), tetrabromobisphenol bismethyl ether (TBBPS‐BME). Based the overall evidence, CONTAM Panel considered vivo genotoxicity of 2,4,6‐TBP be unlikely. Effects liver kidney were as critical effects (2,4,6‐TBP) studies rats. A BMDL10 353 mg/kg body weight (bw) per day for papillary necrosis male rats was identified selected reference point characterisation. derivation a health‐based guidance value not appropriate due major limitations toxicological database. Instead, margin exposure (MOE) approach applied assess possible health concerns. Around 78,200 analytical results food used estimate dietary population. Considering resulting MOE values, all far above an 6000 that does raise concern, accounting uncertainties affecting hazard assessments, concluded with at least 95% probability current concern. Due lack occurrence data, no could performed breastfed or formula‐fed infants. No characterisation any other included assessment, data both toxicity occurrence.

Language: Английский

---

From e-waste to living space: flame retardants contaminating household items add to concern about plastic recycling

Chemosphere, Journal Year: 2024, Volume and Issue: unknown, P. 143319 - 143319

Published: Sept. 1, 2024

Language: Английский

---

Extraction approaches for the isolation of some POPs from lipid-based environmental and food matrices: A review

Reviews in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 1, 2025

Abstract This review examined various analytical approaches for extracting some persistent organic pollutants (POPs) from environmental and food matrices containing lipid components. The impact of the component on extraction such hazardous chemicals fatty is well-known due to their lipophilicity. analysis scientific literature revealed different approaches, typically characterized by use a solvent mixture that leads co-extraction components, followed one or more laborious clean-up steps remove interferents matrix. Despite differences in used, observed recoveries are high, >80%. Additionally, it was found same technique could extract contaminants matrices, resulting loss selectivity method used. uncertainties suggested this consider (i) actual POPs with polar solvents (e.g., acetonitrile) component, which may have higher retention; (ii) laborious, long cleaning non-polar adsorbent phases) affect recoveries; (iii) absence studies investigating concrete constant distribution between extractive solvent/lipid solvent/adsorbent phase. Further, recent application eutectic discussed as promising approach towards green chemistry procedure.

Language: Английский

---

Association between brominated flame retardants and obesity: a mediation analysis through markers of oxidative stress and inflammation

Environmental Health and Preventive Medicine, Journal Year: 2025, Volume and Issue: 30(0), P. 35 - 35

Published: Jan. 1, 2025

Recent studies have provided compelling evidence that exposure to brominated flame retardants (BFRs) can adversely affect human health. We aim explore the potential impact of BFRs on adiposity and central obesity. Data from National Health Nutrition Examination Surveys (NHANES) cycles conducted between 2009 2014 was used study connections variables. After filtering, we analyzed a sample 4,110 adults aged 20 years above. Our goal examine association consequences investigate part played by oxidative stress inflammatory markers as intermediaries. To achieve this, advanced statistical methods such weighted quantile sum (WQS) regression, quantile-based g-computation (QGC), Bayesian kernel machine regression (BKMR). The findings showed among examined chemicals, PBDE85 (weight: 41%), PBDE100 (24%), PBB153 (23%) may be dominant contributors general obesity risk. Upon controlling for all variables could results, it found QGC outcomes indicated positive correlation mixtures occurrence abdominal (OR = 1.187, 95% CI: 1.056-1.334, p 0.004). Significant contributions were made (52%), (27%), (21%). Mediation analysis shows lymphatic cells (LC) albumin (ALB) partially mediate link results BKMR are generally consistent with those WQS QGC. At population level, our research has revealed noteworthy However, further investigation is required through prospective cohort in-depth mechanistic exploratory studies.

Language: Английский

---

Novel and legacy brominated flame retardants in human breast milk and house dust from Denmark

Journal of Environmental Exposure Assessment, Journal Year: 2024, Volume and Issue: 3(2)

Published: Feb. 29, 2024

A suite of novel brominated flame retardants (NBFRs), hexabromocyclododecanes (HBCDDs), polybrominated diphenyl ethers (PBDEs) and dechlorane plus were measured in matched samples house dust (n = 47) human breast milk 40) from Denmark sampled 2007, i.e., shortly after PBDE restrictions implemented Europe providing a valuable reference point. The most abundant BFR was BDE-153 with median concentration 0.79 ng/g lipid followed by BDE-47 (median: 0.61 lipid) BDE-209 0.53 lipid). Levels bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP) comparable 0.78 lipid); however, they based on fewer samples. α-HBCDD the HBCDD 0.24 detected all dominated 432 ng/g) γ-HBCDD 177 ng/g); among NBFRs, highest levels found for decabromodiphenyl ethane (DBDPE) 86.2 BEH-TEBP 26.7 ng/g). BDE-28, 47 153 significantly correlated between serum (rs 0.73-0.81, P < 0.0001); this not case any NBFRs. Intake estimates 3-month-old infant indicated that retardants, far dominant route exposure, whereas only contributed substantially BDE-209, γ-HBCDD, to some extent α-HBCDD. This study is first report exposure NBFRs shows internal similar those PBDEs already at time restrictions.

Language: Английский

---

Phosphorus features halogen –calcium hypophosphite replaces antimony trioxide, reduces smoke, and improves flame retardancy

Thermochimica Acta, Journal Year: 2024, Volume and Issue: 737, P. 179764 - 179764

Published: May 11, 2024

Language: Английский

---

Exposure of children to brominated flame retardants and heavy metals in Morocco: Urine and blood levels in association with global cytosine and adenine methylation

Environment International, Journal Year: 2023, Volume and Issue: 183, P. 108409 - 108409

Published: Dec. 26, 2023

Persistent pollutants, namely brominated flame retardants (BFRs) and heavy metals, are compounds that added to a wide range of products materials for preventing ignition, increasing the functionality or improving their performance, e.g. electric conductivity. The exposure children might consequently be inferred, through indoor dust hand-to-mouth toy-chewing behaviors. current study is aimed at assessing Moroccan BFRs metal elements, evaluating associations with global DNA methylation. First, parents responded questionnaire pertaining children's lifestyle, then blood urine samples were collected from (n= 93) aged between 5 11 years biomonitoring methylation analysis. detected in 54.84% median concentration 0.01 nmol/mL (range: 0.004-0.051 nmol/mL) while elements more than 90% samples. showed no variations methylation, unlike which revealed significant markers, 5-mC, 5-hmCand N⁶-mA levels. may exposed metals several routes. Further research required assess health impacts environmental pollutants ultimately protect population by prevention adverse effects.

Language: Английский

---

Legacy halogenated flame retardants in Canadian human milk from the maternal-infant research on environmental chemicals study

Journal of Environmental Exposure Assessment, Journal Year: 2024, Volume and Issue: 3(3)

Published: July 1, 2024

Polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD) were measured in 298 human milk samples collected from across Canada between 2008 2011 as part of the Maternal-Infant Research on Environmental Chemicals study. PBDEs detected 100% analyzed concentrations ranged 0.071 to 267 ng·g-1 lipid (median 15.6 lipid). The dominant contributors ΣPBDEs (Σ15, 17, 28, 37, 47, 66, 71, 75, 77, 85, 99, 100, 119, 138, 153, 154, 160, 183, 190, 209) PBDE 47 > 153 99 100 28 209. Previously, 209 was considered be a minor contributor ΣPBDE Canadian and, therefore, not reported by our lab. This study showed that when present, can an important (range: below detection - 85.3 lipid; median 0.083 declined slightly early late 2000s. HBCD (Σ α-, β-, γ-) observed 94.0% dominated α-HBCD (93.3%), with β- (9.7%) γ- (28.5%) less frequently detected. maximum ΣHBCD concentration 7.66 value 0.303 These data suggest similarly decreased 2000s sampling for present Maternal age did impact these flame retardants milk. Additionally, other maternal characteristics [e.g., number children woman has had, pre-pregnancy body mass index (BMI), education level] brominated retardant concentrations.

Language: Английский

---