Effect of nano- and micro-polystyrene particles on intestinal epithelial functions and enteric neuronal activity in vitro DOI Creative Commons
Kristin Elfers, Pascal Benz,

Marion Burmester

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract Based on their ubiquitous distribution in various ecosystems, plastic particles of different origin and sizes enter the (human) food chain, are ingested reach gastrointestinal tract, where they interact with intestinal (epithelial) tissue. To a certain extent, may or cross epithelium, getting into contact enteric neurons. Therefore, potential risk for health has been suggested early on. In current study, we aimed to investigate effect polystyrene nano- (100 nm) micro-size (1.0 µm), firstly, epithelial electrophysiological processes using Ussing chamber technique and, secondly, neuronal properties neuroimaging primary cultured The results indicate size-dependent impairment integrity electrogenic glucose transport upon particle application. Additionally, both induced change response parameters nicotinergic stimulation after 24 h incubation. Taken together, these emphasise micro affect as well functionality stress need more detailed investigations present diet physiology involvement nervous system.

Language: Английский

The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD DOI Creative Commons
Magdalena Paplińska‐Goryca, Paulina Misiukiewicz‐Stępień, Maria Wróbel

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

Microplastic particles from the air are inhaled and accumulate in lungs, potentially causing immunological reactions airway tissue injury. This study aimed to evaluate biological effects of polyamide fibres on nasal epithelium co-cultivated with macrophages control, asthma, COPD groups. Nasal epithelial cells alone or co-culture monocyte-derived were exposed for 48 h. We identified 8 differentially expressed genes (DEGs) controls, 309 DEGs asthma (including ANKRD36C, BCL2L15, FCGBP, IL-19), 22 (e.g., IL-19, CAPN14, PGBD5, PTPRH), particularly epithelial/moMφ co-cultures. exposure induced inflammatory cytokine secretion only IL-8 production controls (epithelial/ moMφs co-culture) asthmatic (monoculture) contrast PM2.5, which was a strong inducer. Gene Ontology analysis revealed that microplastic affected sterol cholesterol biosynthesis, secondary alcohol metabolism, acetyl-CoA metabolism cell motility, chemokine signaling, leukocyte migration, chemotaxis COPD. stimulation altered response obstructive lung diseases differently than linking Th2 inflammation, stress modulation, carcinogenesis. Asthmatic more susceptible damage fibre exposure.

Language: Английский

Citations

2
Combined effects of microplastics and flupyradifurone on gut microbiota and oxidative status of honeybees (Apis mellifera L.) DOI
Tong An,

Wangjiang Feng,

Han Li

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 270, P. 121026 - 121026

Published: Feb. 3, 2025

Language: Английский

Citations

1
Microplastic effects on mouse colon in normal and colitis conditions: A literature review DOI Creative Commons
Н. А. Золотова, D. Sh. Dzhalilova, И. С. Цветков

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e18880 - e18880

Published: Feb. 10, 2025

Background Taking into account the global spread of microplastic (MP) pollution, problem MP impact on human health is relevant. enters organism predominantly with water and food, mostly detected in large intestine. Therefore, connection between pollution increase colitis an important question. In order to assess toxic pathogenetic effects MP, experimental studies were actively conducted during recent years, mainly laboratory mice. Objectives The aim our review was summarize systematize data effect mice colon under normal conditions role development intestinal diseases. This manuscript could be relevant for ecologists, biologists, physicians dealing problems related anthropogenic environmental changes inflammatory bowel Survey Methodology search based PubMed about original healthy colitis. Results colon, can cause oxidative stress, increased permeability, immune cell infiltration, production proinflammatory factors, decreased mucus production. affects proliferation, apoptosis, differentiation epithelial cells, expression tight junction components glycocalyx, membrane transport, signaling pathways, metabolome, microflora composition. acute chronic colitis, consumption leads a more pronounced pathological process course. Conclusions may one factors contributing humans. However, further research needed.

Language: Английский

Citations

1
Adverse effects and potential mechanisms of polystyrene microplastics (PS-MPs) on the blood-testis barrier DOI
Jinchen Jiang,

Zhenhao Shu,

Lianglin Qiu

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(7)

Published: June 7, 2024

Language: Английский

Citations

7
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer DOI Open Access
Annalisa Bruno, Melania Dovizio, Cristina Milillo

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3079 - 3079

Published: Sept. 4, 2024

Micro- and nano-plastics (MNPLs) can move along the food chain to higher-level organisms including humans. Three significant routes for MNPLs have been reported: ingestion, inhalation, dermal contact. Accumulating evidence supports intestinal toxicity of ingested their role as drivers increased incidence colorectal cancer (CRC) in high-risk populations such inflammatory bowel disease (IBD) patients. However, mechanisms are largely unknown. In this review, by using leading scientific publication databases (Web Science, Google Scholar, Scopus, PubMed, ScienceDirect), we explored possible effects related MNPL exposure on gut epithelium healthy conditions IBD The summarized idea that oral may contribute epithelial damage, thus promoting sustaining chronic development inflammation, mainly Colonic mucus layer disruption further facilitate passage into bloodstream, contributing toxic different organ systems platelet activation, which may, turn, inflammation CRC development. Further exploration threat human health is warranted reduce potential adverse risk.

Language: Английский

Citations

6
Oral Exposure to Microplastics Affects the Neurochemical Plasticity of Reactive Neurons in the Porcine Jejunum DOI Open Access
Ismena Gałęcka, Jarosław Całka

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2268 - 2268

Published: July 14, 2024

Plastics are present in almost every aspect of our lives. Polyethylene terephthalate (PET) is commonly used the food industry. Microparticles can contaminate and drinks, posing a threat to consumers. The presented study aims determine effect microparticles PET on population neurons positive for selected neurotransmitters enteric nervous system jejunum histological structure. An amount 15 pigs were divided into three groups (control, receiving 0.1 g, 1 g/day/animal orally). After 28 days, fragments collected immunofluorescence examination. obtained results show that changes (injury apical parts villi, accumulations cellular debris mucus, eosinophil infiltration, hyperaemia) more pronounced higher dose microparticles. neuronal nitric oxide synthase-, substance P-positive neurons, depends examined plexus increase percentage galanin-positive decrease cocaine amphetamine-regulated transcript-, vesicular acetylcholine transporter-, vasoactive intestinal peptide-positive do not such relationships. shows potentially have neurotoxic pro-inflammatory effects, but there need further research mechanism this process possible effects.

Language: Английский

Citations

4
Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice DOI Creative Commons
Chaoyu Zhou,

Haiyan Wu,

Lei Zhang

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(1), P. 69 - 69

Published: Jan. 4, 2025

Microplastics, defined as plastic fragments smaller than 5 mm, degrade from larger pollutants, with nanoscale microplastic particles presenting significant biological interactions. This study investigates the toxic effects of polystyrene nanoplastics (PS-NPs) on juvenile mice, which were exposed through lactation milk and drinking water at concentrations 0.01 mg/mL, 0.1 1 mg/mL. The results show that PS-NP exposure during periods caused delayed weight gain impaired organ development, particularly in liver kidneys, without causing functional abnormalities or injuries. primary toxicity PS-NPs was observed intestinal tract, including shortened villi, disrupted tight junctions, inhibited epithelial cell proliferation, oxidative stress responses. These findings highlight importance evaluating developmental environmentally relevant doses.

Language: Английский

Citations

0
The influence of microplastics on hypertension-associated cardiovascular injury via the modulation of gut microbiota DOI
Siyuan Wang,

Keying Yan,

Ying Dong

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125760 - 125760

Published: Jan. 1, 2025

Language: Английский

Citations

0
Short-term subacute di(2-ethylhexyl) phthalate exposure disrupts gut microbiota, metabolome, liver transcriptome, immunity, and induces liver injury in rats DOI Creative Commons
Qian Li, Yaqi Zhang,

Hua Zha

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117948 - 117948

Published: Feb. 26, 2025

Language: Английский

Citations

0
Impacts of polyglycolic acid and analogues on glycolipid metabolism and circadian behavior in zebrafish DOI

Liang Wen,

Shuhui Zhang,

Jialu Luan

et al.

NanoImpact, Journal Year: 2025, Volume and Issue: 37, P. 100546 - 100546

Published: Jan. 1, 2025

Language: Английский

Citations

0