Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
283, P. 116848 - 116848
Published: Aug. 7, 2024
This
comprehensive
review
articulates
critical
insights
into
the
nexus
of
environmental
stressors
and
their
health
impacts
across
diverse
species,
underscoring
significant
findings
that
reveal
profound
effects
on
both
wildlife
human
systems.
Central
to
our
examination
is
role
pollutants,
climate
variables,
pathogens
in
contributing
complex
disease
dynamics
physiological
disruptions,
with
particular
emphasis
immune
endocrine
functions.
research
brings
light
emerging
evidence
severe
implications
pressures
a
variety
taxa,
including
predatory
mammals,
raptorial
birds,
seabirds,
fish,
humans,
which
are
pivotal
as
indicators
broader
ecosystem
stability.
We
delve
nuanced
interplay
between
degradation
zoonotic
diseases,
highlighting
novel
intersections
pose
risks
biodiversity
populations.
The
critically
evaluates
current
methodologies
advances
understanding
morphological,
histopathological,
biochemical
responses
these
organisms
stressors.
discuss
for
conservation
strategies,
advocating
more
integrated
approach
incorporates
zoonoses
pollution
control.
synthesis
not
only
contributes
academic
discourse
but
also
aims
influence
policy
by
aligning
Global
Goals
Sustainable
Development.
It
underscores
urgent
need
sustainable
interactions
humans
environments,
preserving
ensuring
global
security.
By
presenting
detailed
analysis
interdependencies
biological
health,
this
highlights
gaps
provides
foundation
future
studies
aimed
at
mitigating
pressing
issues.
Our
study
it
proposes
integrative
actionable
strategies
address
challenges
intersection
change
public
marking
crucial
step
forward
planetary
science.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(38), P. 14127 - 14137
Published: Sept. 8, 2023
In
this
study,
we
investigated
the
mechanism
underlying
perturbation
of
hepatic
lipid
metabolism
in
response
to
micro/nanoplastic
(MP/NP)
exposure
at
environmentally
relevant
concentrations.
Polystyrene
(PS)
MPs/NPs
with
different
sizes
(0.1,
0.5,
and
5.0
μm)
were
studied
for
their
effects
on
homeostasis
function
Nile
tilapia
(Oreochromis
niloticus)
liver.
Results
showed
that
PS
readily
internalized
accumulated
various
internal
organs/tissues,
especially
fish
liver
muscle.
Smaller-sized
NPs
caused
more
severe
toxicity
than
larger
MPs,
including
steatosis,
inflammatory
response,
disturbed
function.
Mechanistically,
a
particle
size
100
nm
perturbed
protein
endoplasmic
reticulum
(ER)
by
inhibiting
expression
chaperone
proteins
genes
involved
ER-associated
degradation.
This
led
activation
PERK-eIF2α
pathway,
which
dysfunction
metabolism.
Induction
oxidative
stress
Nrf2/Keap1
pathway
also
NP-induced
accumulation.
These
findings
highlight
potential
adverse
environmental
aquatic
organisms,
raising
concerns
about
ecotoxicity
food
safety.
International Journal of Environmental Research and Public Health,
Journal Year:
2023,
Volume and Issue:
20(17), P. 6667 - 6667
Published: Aug. 28, 2023
Plastics,
due
to
their
varied
properties,
find
use
in
different
sectors
such
as
agriculture,
packaging,
pharmaceuticals,
textiles,
and
construction,
mention
a
few.
Excessive
of
plastics
results
lot
plastic
waste
buildup.
Poorly
managed
(as
shown
by
heaps
on
dumpsites,
free
spaces,
along
roads,
marine
systems)
the
landfills,
are
just
fraction
environment.
A
complete
picture
should
include
micro
nano-plastics
(MNPs)
hydrosphere,
biosphere,
lithosphere,
atmosphere,
current
extreme
weather
conditions
(which
effects
climate
change),
wear
tear,
other
factors
promote
MNP
formation.
MNPs
pose
threat
environment
more
than
pristine
counterparts.
This
review
highlights
entry
occurrence
primary
secondary
soil,
water
air,
together
with
aging.
Furthermore,
uptake
internalization,
plants,
animals,
humans
discussed,
toxicity
effects.
Finally,
future
perspective
conclusion
given.
The
material
utilized
this
work
was
acquired
from
published
articles
internet
using
keywords
waste,
degradation,
microplastic,
aging,
toxicity.
Frontiers in Toxicology,
Journal Year:
2023,
Volume and Issue:
5
Published: July 14, 2023
Plastic
is
a
pervasive
material
that
has
become
an
indispensable
part
of
our
daily
lives
and
used
in
various
commercial
products.
However,
plastic
waste
significantly
impacted
the
environment,
accumulating
water
land
ecosystems
harming
all
forms
life.
When
degrades,
it
breaks
down
into
smaller
particles
called
microplastics
(MPs),
which
can
further
breakdown
nanoplastics
(NPs).
Due
to
their
small
size
potential
toxicity
humans,
NPs
are
particular
concern.
During
COVID-19
pandemic,
production
had
reached
unprecedented
levels,
including
essential
medical
kits,
food
bags,
personal
protective
equipment
(PPE),
generate
MPs
when
burned.
have
been
detected
locations,
such
as
air,
food,
soil,
but
understanding
adverse
health
effects
limited.
This
review
aims
provide
comprehensive
overview
sources,
interactions,
ecotoxicity,
routes
exposure,
mechanisms,
detection
methods,
future
directions
for
safety
evaluation
NPs.
would
improve
impact
on
environment
identify
ways
address
this
global
crisis.
