Effects of timing of complementary food introduction on childhood food allergy development: A modified role of ambient air pollution exposure

Building and Environment, Journal Year: 2023, Volume and Issue: 231, P. 110065 - 110065

Published: Feb. 2, 2023

Language: Английский

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Air pollutants contribute to epithelial barrier dysfunction and allergic diseases

Annals of Allergy Asthma & Immunology, Journal Year: 2023, Volume and Issue: 132(4), P. 433 - 439

Published: Nov. 23, 2023

Language: Английский

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One allergy: one exposure and one pathway

Pediatric Research, Journal Year: 2024, Volume and Issue: 95(7), P. 1683 - 1684

Published: Feb. 2, 2024

Language: Английский

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Air pollution and rhinitis

Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5

Published: May 28, 2024

Rhinitis arises from either allergic or non-allergic inflammation of the nasal mucosa, characterized by infiltration inflammatory cells into tissue and secretions, along with structural alterations in mucosa. The pathways through which air pollution affects rhinitis may diverge those affecting asthma. This article aims to review effects diverse pollutants on nose, correlation climate change pollution, how they aggravate symptoms patients rhinitis.

Language: Английский

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Towards an optimized model of food allergy in zebrafish

Molecular Immunology, Journal Year: 2024, Volume and Issue: 173, P. 110 - 116

Published: Aug. 6, 2024

Language: Английский

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The potential of orally exposed risk factors and constituents aggravating food allergy: Possible mechanism and target cells

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(5)

Published: Sept. 1, 2024

Abstract Food allergy is a significant concern for the health of humans worldwide. In addition to dietary exposure food allergens, genetic and environmental factors also play an important role in development allergy. However, only tip iceberg risk has been identified. The importance caused by orally exposed constituents, including veterinary drugs, pesticides, processed foods/derivatives, nanoparticles, microplastics, pathogens, toxins, additives, intake salt/sugar/total fat, vitamin D, therapeutic are highlighted discussed this review. Moreover, epithelial barrier hypothesis, which closely associated with occurrence allergy, introduced. Additionally, several constituents that have reported disrupt elucidated. Finally, possible mechanisms key immune cells aggravating overviewed. Further work should be conducted define specific mechanism these driving will central targeted therapy

Language: Английский

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The Relationship Between Asthma and Food Allergies in Children

Children, Journal Year: 2024, Volume and Issue: 11(11), P. 1295 - 1295

Published: Oct. 26, 2024

Asthma and food allergy are two complex allergic diseases with an increasing prevalence in childhood. They share risk factors, including atopic family history, dermatitis, allergen sensitization, T2 inflammatory pathways. Several studies have shown that children a allergy, the of developing asthma, particularly early childhood, is high. Food intake or inhalation aerosolized allergens can induce respiratory symptoms such as bronchospasm. Patients both conditions increased severe asthma exacerbations, hospitalization, mortality. The current management clinical hypersensitivity primarily involves dietary avoidance use self-injectable adrenaline for reactions. Poorly controlled limits prescription oral immunotherapy to foods, which has emerged alternative therapy managing allergies. Biological therapies effective been explored treating Omalizumab improves control and, either alone combination immunotherapy, increases threshold tolerance. Understanding interplay between crucial successful treatment approaches ameliorating patient results.

Language: Английский

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Different airborne particulates trigger distinct immune pathways leading to peanut allergy in a mouse model

Allergy, Journal Year: 2023, Volume and Issue: 79(2), P. 432 - 444

Published: Oct. 7, 2023

Abstract Background Environmental exposure to peanut through non‐oral routes is a risk factor for allergy. Early‐life air pollutants, including particulate matter (PM), associated with sensitization foods unknown mechanisms. We investigated whether PM promotes environmental and the development of allergy in mouse model. Methods C57BL/6J mice were co‐exposed either urban (UPM) or diesel exhaust particles (DEP) via airways assessed anaphylaxis following challenge. Peanut‐specific CD4 + T helper (Th) cell responses characterized by flow cytometry Th cytokine production. Mice lacking select innate immune signaling genes used study mechanisms PM‐induced Results Airway co‐exposure UPM‐ DEP‐induced systemic Exposure UPM DEP triggered activation migration lung dendritic cells draining lymph nodes induction peanut‐specific cells. distinct responses, but both stimulated expansion follicular (Tfh) essential development. MyD88 was critical allergy, whereas TLR4 dispensable. Tfh‐cell differentiation depended on IL‐1 not IL‐33 signaling, neither alone necessary UPM‐mediated sensitization. Conclusion induces Tfh mice.

Language: Английский

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Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(4)

Published: April 1, 2024

Evidence suggests that prenatal air pollution exposure alters DNA methylation (DNAm), which could go on to affect long-term health. It remains unclear whether DNAm alterations present at birth persist through early life. Identifying persistent changes would provide greater insight into the molecular mechanisms contributing association of with atopic diseases.

Language: Английский

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Extracellular adenosine triphosphate: A new gateway for food allergy mechanism research?

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141821 - 141821

Published: Oct. 30, 2024

Language: Английский

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