Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer DOI
Martina Montanari, Maria Meringolo, Ilham El Atiallah

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The relationship between cancer and neurodegeneration has spurred extensive scientific discourse, challenging their historical classification as distinct disorders. While signifies uncontrolled cellular proliferation marks progressive neuronal loss, recent insights highlight intriguing interconnections these seemingly disparate conditions. Cancer entails perpetual signaling for growth, evasion of growth inhibitors, resistance to cell death, acquisition replicative immortality, stimulation blood vessel (angiogenesis), initiation invasion metastasis. Conversely, investigations emphasize disrupted energy regulation immune surveillance key traits arising from genome instability, mutations, inflammation driving tumorigenesis. Neurodegeneration involves malfunction depletion, synaptic impairment, protein abnormality aggregations contributing muscle atrophy cognitive deficits. Varied clinical studies underscore contrasting correlations neurodegeneration, hinting at mirrored molecular pathways that foster resilience or vulnerability. Research explores in tumorigenesis, shared with neurodegenerative Aberrant expression mutations crucial genes implicated also surface contexts. Debates persist on the nature contemplating inverse associations pathways. Understanding complex interplay, encompassing genetics, mechanisms, environmental influences, remains pivotal unraveling connections. This review perspective might share fundamental genetic links, delving into potential implications onset progression.

Language: Английский

Emerging role of RNA acetylation modification ac4C in diseases: Current advances and future challenges DOI
Jie Luo, Jingsong Cao, Cong Chen

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 213, P. 115628 - 115628

Published: May 27, 2023

Language: Английский

Citations

32
Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance DOI
Zhibin Zhang,

Z.M. Guo K.L. Gao,

Huimin Fang

et al.

Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(3), P. 867 - 888

Published: Jan. 22, 2024

Language: Английский

Citations

7
A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer DOI Creative Commons
Jitendra Gupta, Abdulrahman T. Ahmed, Nahla A. Tayyib

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115337 - 115337

Published: Sept. 4, 2023

The fourth common reason of death among patients is gastric cancer (GC) and it a dominant tumor type in Ease Asia. One the problems GC therapy chemoresistance. Cisplatin (CP) platinum compound that causes DNA damage reducing progression viability cells. However, due to hyperactivation drug efflux pumps, dysregulation genes interactions microenvironment, cells can develop resistance CP chemotherapy. current review focuses on emergence with emphasizing molecular pathways, pharmacological compounds for reversing chemoresistance role nanostructures. Changes cell mechanisms such as upregulation pro-survival autophagy prevent CP-mediated apoptosis results resistance. Moreover, increase metastasis via EMT induction induces Dysregulation pathways PTEN, PI3K/Akt, Nrf2 others result changes response Non-coding RNAs determine application activity distinct sensitivity Due efficacy exosomes transferring bioactive molecules RNA cells, also newest progresses overcoming nanoplatforms delivery they accumulation at site by suppressing carcinogenic factors biological barriers, toxicity

Language: Английский

Citations

15
Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma: Emphasis on cell death mechanism crosstalk DOI Creative Commons
Gang Wang,

Xiaodi Jiang,

Pedram Torabian

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216744 - 216744

Published: March 1, 2024

Hepatocellular carcinoma (HCC) stands as a formidable global health challenge due to its prevalence, marked by high mortality and morbidity rates. This cancer type exhibits multifaceted etiology, prominently linked viral infections, non-alcoholic fatty liver disease, genomic mutations. The inherent heterogeneity of HCC, coupled with proclivity for developing drug resistance, presents obstacles effective therapeutic interventions. Autophagy, fundamental catabolic process, plays pivotal role in maintaining cellular homeostasis, responding stressors such nutrient deprivation. In the context tumor cells exploit autophagy, either augmenting or impeding activity, thereby influencing tumorigenesis. comprehensive review underscores dualistic autophagy acting both pro-survival pro-death mechanism, impacting trajectory anti-carcinogenic potential is evident ability enhance apoptosis ferroptosis HCC cells. Pertinently, dysregulated fosters resistance carcinogenic context. Both epigenetic factors can regulate progression. Recognizing paramount importance progression, this introduces pharmacological compounds capable modulating autophagy—either inducing inhibiting it, promising avenues therapy.

Language: Английский

Citations

5
Proteome-wide Ligand and Target Discovery by Using Strain-Enabled Cyclopropane Electrophiles DOI
Yue Liu, Zhongtang Yu, Peishan Li

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(30), P. 20823 - 20836

Published: July 17, 2024

The evolving use of covalent ligands as chemical probes and therapeutic agents could greatly benefit from an expanded array cysteine-reactive electrophiles for efficient versatile proteome profiling. Herein, to expand the current repertoire electrophiles, we developed a new class strain-enabled based on cyclopropanes. Proteome profiling has unveiled that C163 lactate dehydrogenase A (LDHA) C88 adhesion regulating molecule 1 (ADRM1) are ligandable residues modulate protein functions. Moreover, fragment-based ligand discovery (FBLD) revealed one fragment (

Language: Английский

Citations

4
The miRNA‐mRNA Regulatory Network in Human Hepatocellular Carcinoma by Transcriptomic Analysis From GEO DOI Creative Commons
Razieh Heidari, Vahideh Assadollahi, Seyedeh Negar Marashi

et al.

Cancer Reports, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 1, 2025

ABSTRACT Background Bioinformatics analysis of hepatocellular carcinoma (HCC) expression profiles can aid in understanding its molecular mechanisms and identifying new targets for diagnosis treatment. Aim In this study, we analyzed profile datasets miRNA related to HCC from the GEO using R software detect differentially expressed genes (DEGs) miRNAs (DEmiRs). Methods results Common DEGs were identified, a PPI network was constructed STRING database Cytoscape identify hub genes. The reduced levels tumor suppressor or down regulated DEmiRs may be increased oncogenes, oncomirs up decreased cancerous cells. According strategy, DEGs, also selected. multimir package employed predict target then DEmiRs‐hub gene created. We identified approximately 1000 overlapping 60 DEmiRs. Hub included RRM2, MELK , KIF11 KIF23 NCAPG DLGAP5 BUB1B AURKB CCNB1 KIF20A CCNA2 TTK PBK TOP2A CDK1 MAD2L1 BIRC5 ASPM CDCA8 CENPF all associated with significantly worse survival HCC. miR‐224, miR‐24, miR‐182, miRNA‐1‐3p, miR‐30a, miR‐27a, miR‐214 as important targeting more than six Conclusion Generally, our findings offer insight into interaction development by bioinformatics analysis, information that prove useful biomarkers therapeutic

Language: Английский

Citations

0
Lactate promotes the epithelial-mesenchymal transition of liver cancer cells via TWIST1 lactylation DOI
Huimin Wang, Xin Wu, Shan Yu

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114474 - 114474

Published: Feb. 1, 2025

Language: Английский

Citations

0
MAZ-mediated N6-methyladenosine modification of ZEB1 promotes hepatocellular carcinoma progression by regulating METTL3 DOI Creative Commons

Di Li,

Xu Li,

Ruyuan Liu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Hepatocellular carcinoma (HCC) has a hidden onset and high malignancy. Its metastasis, recurrence, short survival time have always been difficult hot spot in clinical practice. Our previous study revealed that myc-associated zinc finger protein (MAZ) is highly upregulated HCC tissues may promote the proliferation metastasis of cells by inducing epithelial-mesenchymal transformation (EMT) process. However, specific regulatory mechanism which MAZ functions as an oncogene still not fully elucidated. Immunohistochemical staining bioinformatics analyses were conducted to measure expression MAZ, key m6A enzymes, ZEB1 tissues. RNA sequencing (RNA-seq) knockdown human mRNA (m6A-seq) intersected screen downstream targets for both methylation. The correlations between its analyzed dual-luciferase assays cell rescue experiments. Here, we report first involved methylation targeting transcriptional regulation enzymes. was significantly correlated with enzymes lines. Moreover, could bind promoters multivariate Cox regression analysis suggested METTL3 independent risk factors patients. Through RNA-seq m6A-seq, screened out EMT regulators TRIM50 Mechanistically, sites confidence identified SRAMP, there significant relationships cells. A nomogram model established better display combined effect METTL3, on prognosis. promising application prognosis, further suggesting can be used potential molecular biomarker diagnosis

Language: Английский

Citations

0
Mechanistic studies and therapeutic potential of angiopoietin in head and neck tumor angiogenesis DOI Creative Commons

Xiaojuan Zhong,

Yujie Fei,

Haihui Zhao

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Head and neck tumors represent a prevalent category of oral maxillofacial malignancies, posing significant therapeutic prognostic challenges due to their complex anatomical structure, tumor heterogeneity, resistance conventional therapies. Recent studies have highlighted the strong association between progression neoangiogenesis, with angiopoietin (ANG) family playing central role in this process. Comprising ANG1, ANG2, ANG3, ANG4, these factors regulate multiple signaling pathways that promote cellular growth, differentiation, proliferation, thereby driving angiogenesis accelerating growth metastasis. Therefore, comprehensive investigation ANG family's head may offer critical insights into tumorigenesis mechanisms unveil novel targets. Such research has potential improve treatment outcomes enhance quality life for patients.

Language: Английский

Citations

0
RBMX2: A Pivotal Regulator LinkingMycobacterium bovisInfection to Epithelial-Mesenchymal Transition and Lung Cancer Progression DOI Creative Commons
Chao Wang,

Yongchong Peng,

Hongxin Yang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract The emergence and progression of tuberculosis (TB) result from the intricate interplay among pathogen, host, environmental factors. In 2022, there were 10.6 million new TB cases reported globally, leading to 1.3 deaths. regions with a high prevalence zoonotic TB, Mycobacterium bovis ( M. ) accounts for approximately 10% human cases. immune evasion mechanisms latent infections tb complicate our understanding host response TB. This study identifies novel factor, RNA-binding motif protein X-linked 2 (RBMX2), which shows potential against infection. However, specific molecular roles RBMX2 during infection remain poorly understood. Our investigations revealed that following infection, was highly expressed in various cell types, including embryonic bovine lung (EBL) cells, macrophage (BoMac) alveolar primary pulmonary epithelial cells (A549). Using multifaceted approach included global transcriptional sequencing, proteomics, adhesion assays, ChIP-PCR, Western blot analyses, we demonstrated inhibits tight junction formation EBL while promoting invasion through activation p65 pathway. Furthermore, data suggest regulates epithelial-mesenchymal transition (EMT), process strongly associated cancer, as indicated by transcriptomics, metabolomics analyses. To further explore relationship between analyzed TIMER2.0 database found elevated expression levels adenocarcinoma (LUAD) squamous carcinoma (LUSC) tissues compared normal tissues. finding corroborated immunofluorescence validation. After constructing an -infected BoMac-induced EBL-EMT model, confirmed contributes EMT activating p65/MMP-9 pathway post-infection. elucidates role factor anti-TB functions inhibit TB-induced EMT. These insights have vital implications development vaccines therapeutic strategies TB-mediated highlighting promising target future research.

Language: Английский

Citations

0