Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer DOI
Martina Montanari, Maria Meringolo, Ilham El Atiallah

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The relationship between cancer and neurodegeneration has spurred extensive scientific discourse, challenging their historical classification as distinct disorders. While signifies uncontrolled cellular proliferation marks progressive neuronal loss, recent insights highlight intriguing interconnections these seemingly disparate conditions. Cancer entails perpetual signaling for growth, evasion of growth inhibitors, resistance to cell death, acquisition replicative immortality, stimulation blood vessel (angiogenesis), initiation invasion metastasis. Conversely, investigations emphasize disrupted energy regulation immune surveillance key traits arising from genome instability, mutations, inflammation driving tumorigenesis. Neurodegeneration involves malfunction depletion, synaptic impairment, protein abnormality aggregations contributing muscle atrophy cognitive deficits. Varied clinical studies underscore contrasting correlations neurodegeneration, hinting at mirrored molecular pathways that foster resilience or vulnerability. Research explores in tumorigenesis, shared with neurodegenerative Aberrant expression mutations crucial genes implicated also surface contexts. Debates persist on the nature contemplating inverse associations pathways. Understanding complex interplay, encompassing genetics, mechanisms, environmental influences, remains pivotal unraveling connections. This review perspective might share fundamental genetic links, delving into potential implications onset progression.

Language: Английский

Deciphering the Multifaceted Role of microRNAs in Hepatocellular Carcinoma: Integrating Literature Review and Bioinformatics Analysis for Therapeutic Insights DOI Creative Commons

Fereshteh Rahdan,

Alihossein Saberi, Neda Saraygord‐Afshari

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e39489 - e39489

Published: Oct. 1, 2024

Language: Английский

Citations

3
miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers DOI
Ameer S. Sahib,

Amjid Fawzi,

Rahman S. Zabibah

et al.

Cellular Signalling, Journal Year: 2023, Volume and Issue: 112, P. 110881 - 110881

Published: Sept. 4, 2023

Language: Английский

Citations

6
AGR2: The Covert Driver and New Dawn of Hepatobiliary and Pancreatic Cancer Treatment DOI Creative Commons
Shen Qu, Weili Jia, Ye Nie

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 743 - 743

Published: June 23, 2024

The anterior gradient protein 2 (AGR2) plays a crucial role in facilitating the formation of disulfide bonds within endoplasmic reticulum (ER). Research suggests that AGR2 can function as an oncogene, with its heightened expression linked to advancement hepatobiliary and pancreatic cancers through invasion metastasis. Notably, not only serves pro-oncogenic agent but also downstream targeting protein, indirectly fostering cancer progression. This comprehensive review delves into established functions patterns AGR2, emphasizing pivotal progression, particularly malignancies. Furthermore, emerges potential prognostic marker promising target for immunotherapy, offering novel avenues treatment enhancing patient outcomes.

Language: Английский

Citations

2
Nrf2 in human cancers: biological significance and therapeutic potential DOI
Yu Tian, Lixin Tang, Xin Wang

et al.

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(8), P. 3935 - 3961

Published: Jan. 1, 2024

The nuclear factor-erythroid 2-related factor 2 (Nrf2) is able to control the redox balance in cells responding oxidative damage and other stress signals. Nrf2 upregulation can elevate levels of antioxidant enzymes support against death. In spite protective function physiological conditions, stimulation cancer has been favour tumorigenesis. Since dysregulation molecular pathways mutations/deletions are common tumors, be a promising therapeutic target. overexpression prevent cell death tumor by increasing survival rate cells, ensures carcinogenesis. Moreover, induction promote invasion metastasis cells. stimulates EMT increase metastasis. Furthermore, regarding Nrf2, its triggers chemoresistance. natural products regulate therapy reverse drug resistance. nanostructures specifically target signaling therapy. current review discusses potential proliferation, Then, capacity for suppressing Nrf2-mediated progression discussed.

Language: Английский

Citations

2
A predicted epithelial-to-mesenchymal transition-associated mRNA/miRNA axis contributes to the progression of diabetic liver disease DOI Creative Commons
Alina-Veronica Ghionescu, Andrei Sorop,

Ekaterini Linioudaki

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 12, 2024

Despite public health measures, type 2 diabetes (T2D) is still a significant concern worldwide, given its associated complications, including hepatic alterations. The role of epithelial-to-mesenchymal transition (EMT) in liver fibrosis well established. However, effects on the progression diabetic diseases are not understood. Therefore, this study aims to investigate mRNA/miRNA axes involved process. Bioinformatic analysis revealed new EMT-associated genes (CDH2, ITGB1, COL4A1, COL1A1, TNC, CCN2, and JUN), which showed higher expression obese T2D hepatocellular carcinoma (HCC) patients. In addition, six miRNAs (miR-21-5p, miR-26a-5p, miR-34a-5p, miR-106a-5p, miR-320a-3p miR-424-5p) have been found as potential targets. Among them, miR-26a-5p miR-424-5p were significantly downregulated nonalcoholic steatohepatitis (NASH) HCC (p < 0.05), being considered negative regulators EMT our mesenchymal culture model, negatively regulated cadherin (also known N-cadherin, CDH2) promoted 1 E-cadherin, CDH1) expression. Our results reveal molecules tumor development. Moreover, we observe that impairs initial stages disease by inhibiting CDH2 could be valuable target pathology.

Language: Английский

Citations

2
Insights on epithelial cells at the single-cell level in hepatocellular carcinoma prognosis and response to chemotherapy DOI Creative Commons
Wenqian Qi, Qian Zhang

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 17, 2023

Background: Hepatocellular carcinoma (HCC) originates from Epithelial cells, and epithelial lineage plasticity has become a promising research direction for advancing HCC treatment. This study aims to focus on cells provide target insights detecting prognosis response drug therapy. Methods: Single-cell RNA sequencing (scRNA-seq) data GSE149614 were clustered using Seurat, the differentiation evolution of analyzed by Monocle 2. Scissor+ Scissor- associated with prognostic phenotypes bulk RNA-seq screened Scissor algorithm differential analysis screen candidate genes. Candidate genes overlapped related univariate Cox regression, Least Absolute Shrinkage Selection Operator (LASSO) sparse penalty was imposed intersection construct risk assessment system. Results: Eight major cell subpopulations identified, among which proportion in non-tumor liver tissues significantly different, its increased advanced clinical stage. During progression HCC, whole trajectory towards enhanced proliferation. Differential between 1,265 upregulated 191 downregulated Wherein, enriched Cell processes, Genetic information processing, Metabolism Human disease Infection. Nevertheless, immune system pathways took main proportions pathways. There 17 common genes, CDC20, G6PD PLOD2 selected as components constructing Risk score showed significant correlation tumor stage, epithelial-mesenchymal transition (EMT) 22 therapeutic drugs, an independent factor HCC. Conclusion: revealed cellular composition functional landscape further deterioration established 3-gene model, closely features, EMT, sensitivity prediction. These findings provided patient therapy detection

Language: Английский

Citations

4
Angiopoietin-2 and the Vascular Endothelial Growth Factor Promote Migration and Invasion in Hepatocellular Carcinoma- and Intrahepatic Cholangiocarcinoma-Derived Spheroids DOI Creative Commons
Adriana Romanzi, Fabiola Milosa, Gemma Marcelli

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 12(1), P. 87 - 87

Published: Dec. 30, 2023

Aggressive hepatocellular carcinoma (HCC) overexpressing Angiopoietin-2 (ANG-2) (a protein linked with angiogenesis, proliferation, and epithelial–mesenchymal transition (EMT)), shares 95% of up-regulated genes a similar poor prognosis the proliferative subgroup intrahepatic cholangiocarcinoma (iCCA). We analyzed pro-invasive effect ANG-2 its regulator vascular endothelial growth factor (VEGF) on HCC CCA spheroids to uncover posUsible common ways response. Four cell lines were used: Hep3B HepG2 (HCC), HuCC-T1 (iCCA), EGI-1 (extrahepatic CCA). treated recombinant human (rh) and/or VEGF then observed changes at baseline, after 24 h, again 48 h. Proangiogenic stimuli increased migration invasion capability in HCC- iCCA-derived associated modification EMT phenotypic markers decrease E-cadherin an increase N-cadherin Vimentin), especially front. Inhibitors targeting (Trebananib) (Bevacizumab) effectively blocked ability that had been stimulated rh-ANG-2 rh-VEGF. Overall, our findings highlight critical role played by enhancing migrate invade, which are key processes cancer progression.

Language: Английский

Citations

4
Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer DOI
Martina Montanari, Maria Meringolo, Ilham El Atiallah

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The relationship between cancer and neurodegeneration has spurred extensive scientific discourse, challenging their historical classification as distinct disorders. While signifies uncontrolled cellular proliferation marks progressive neuronal loss, recent insights highlight intriguing interconnections these seemingly disparate conditions. Cancer entails perpetual signaling for growth, evasion of growth inhibitors, resistance to cell death, acquisition replicative immortality, stimulation blood vessel (angiogenesis), initiation invasion metastasis. Conversely, investigations emphasize disrupted energy regulation immune surveillance key traits arising from genome instability, mutations, inflammation driving tumorigenesis. Neurodegeneration involves malfunction depletion, synaptic impairment, protein abnormality aggregations contributing muscle atrophy cognitive deficits. Varied clinical studies underscore contrasting correlations neurodegeneration, hinting at mirrored molecular pathways that foster resilience or vulnerability. Research explores in tumorigenesis, shared with neurodegenerative Aberrant expression mutations crucial genes implicated also surface contexts. Debates persist on the nature contemplating inverse associations pathways. Understanding complex interplay, encompassing genetics, mechanisms, environmental influences, remains pivotal unraveling connections. This review perspective might share fundamental genetic links, delving into potential implications onset progression.

Language: Английский

Citations

0