ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(41)
Published: Oct. 28, 2024
Abstract
Sugars,
as
cryoprotectants,
can
be
added
to
NP
formulations
before
lyophilization
ensure
that
NPs
retain
their
size
during
long‐term
storage.
In
this
study,
mannitol,
glucose,
and
sucrose
were
used
at
different
concentrations
extend
the
storage
time
of
doxorubicin
(DOX)‐loaded
PLGA‐NPs
prepared
using
two
copolymer
ratios
(75
:
25
50
50)
temperatures
(−20,
+4,
+25
°C).
After
lyophilization,
a
glucose
or
concentration
only
5
%
for
DOX‐PLGA‐75
25‐NP
10
DOX‐PLGA‐50
50‐NP
found
prevent
agglomeration
up
4
months
−20
°C.
It
is
noteworthy
after
°C
months,
was
prevented
in
content
both
types.
On
other
hand,
expected,
no
sugar
type
could
The
sizes
encapsulation
efficiencies
(EE%)
221.8±2.20
45.4
221.5±1.31
48.7
25‐NP,
respectively.
Furthermore,
release
profiles
DOX
investigated
by
UV‐Vis
analyses.
DSC
analysis
revealed
present
free
form
amorphous
NPs.
Consequently,
PLGA
have
an
impact
on
stability
loaded
lyophilizates,
DOX‐loaded
with
75
stored
+4
when
combined
appropriate
contents
concentrations,
demonstrating
versatility
these
materials.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 6, 2023
Abstract
Skin
cancer
is
a
global
threat
to
the
healthcare
system
and
estimated
incline
tremendously
in
next
20
years,
if
not
diagnosed
at
an
early
stage.
Even
though
it
curable
stage,
novel
drug
identification,
clinical
success,
resistance
another
major
challenge.
To
bridge
gap
bring
effective
treatment,
important
understand
etiology
of
skin
carcinoma,
mechanism
cell
proliferation,
factors
affecting
growth,
resistance.
The
current
article
focusses
on
understanding
structural
diversity
cancers,
treatments
available
till
date
including
phytocompounds,
chemotherapy,
radiotherapy,
photothermal
therapy,
surgery,
combination
molecular
targets
associated
with
growth
metastasis,
special
emphasis
nanotechnology-based
approaches
for
downregulating
deleterious
disease.
A
detailed
analysis
respect
types
nanoparticles
their
scope
overcoming
multidrug
as
well
trials
has
been
discussed.
Graphical
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 20, 2025
Ovarian
cancer
is
one
the
deadliest
disease
wherein
survival
rate
very
low.
Despite
of
advances
in
medical
sciences,
researches
are
still
at
stage
infancy
where
patients
succumbing
to
this
malignancy.
Multidrug
resistance,
toxicity,
mode
treatment
related
issues
like
catheter
complication
poises
a
number
challenges
scientists
worldwide.
Novel
therapy
now
thus
being
focussed
sensitive
cells
more
towards
treatment.
Gold
nanoparticles
(Au
NPs),
known
for
their
high
biocompatibility,
and
strong
optical
magnetic
responses,
have
emerged
as
promising
agents
both
diagnosis
ovarian
cancer.
Owing
physical
characteristics,
AuNPs
may
be
used
adjuvants
bioimaging,
radiotherapy
fluorescence
imaging.
As
result,
these
characteristics
substantially
support
biological
domains.
In
addition
therapeutic
potential,
Au
NPs
exhibit
surface
plasmon
resonance
(SPR)
properties,
enhancing
imaging
techniques
early
detection
tumors.
Furthermore,
chemical
properties
such
Magnetic
Resonance
Imaging
Properties,
X-ray
property,
Two-photon
or
multiphoton
imaging,
Optical
coherence
tomography
(OCT)
enhance
use
diagnosis.
This
paper
highlights
targeting
potential
by
has
been
discussed.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1253 - 1253
Published: April 30, 2024
Biodegradable
polymers
have
been
extensively
researched
in
the
field
of
biomedicine.
Polylactic-co-glycolic
acid
(PLGA),
a
biodegradable
polymer
material,
has
widely
used
drug
delivery
systems
and
shown
great
potential
various
medical
fields,
including
vaccines,
tissue
engineering
such
as
bone
regeneration
wound
healing,
3D
printing.
Cancer,
group
diseases
with
high
mortality
rates
worldwide,
recently
garnered
significant
attention
immune
therapy
research.
In
recent
years,
there
growing
interest
function
PLGA
tumor
immunotherapy.
immunotherapy,
can
serve
carrier
to
load
antigens
on
its
surface,
thereby
enhancing
system’s
ability
attack
cells.
Additionally,
be
formulate
vaccines
immunoadjuvants,
efficacy
nanoparticles
(NPs)
also
enhance
effectiveness
immunotherapy
by
regulating
activity
differentiation
cells,
improving
expression
presentation
antigens.
Furthermore,
due
diverse
physical
properties
surface
modifications
PLGA,
it
wider
range
applications
through
loading
types
drugs
or
other
innovative
substances.
We
aim
highlight
advances
challenges
plga
oncology
stimulate
further
research
development
PLGA-based
approaches,
more
effective
personalized
cancer
therapies.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7015 - 7057
Published: Oct. 18, 2024
Biomedical
polymers
play
a
key
role
in
preventing,
diagnosing,
and
treating
diseases,
showcasing
wide
range
of
applications.
Their
unique
advantages,
such
as
rich
source,
good
biocompatibility,
excellent
modifiability,
make
them
ideal
biomaterials
for
drug
delivery,
biomedical
imaging,
tissue
engineering.
However,
conventional
suffer
from
poor
degradation
