Targeting triple negative breast cancer stem cells using nanocarriers

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: March 7, 2024

Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, treatment responses. Categorization of based on the presence or absence estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), leading to such as luminal A, B, HER2-positive, triple-negative breast (TNBC). TNBC, comprising around 20% all cancers, lacks expression ER, PR, HER2 receptors, rendering it unresponsive targeted therapies presenting significant challenges in treatment. TNBC associated with aggressive behavior, high rates recurrence, resistance chemotherapy. Tumor initiation, progression, are attributed stem cells (BCSCs), which possess self-renewal, differentiation, tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), immune modulation (cytokines, checkpoint inhibitors) among key targets discussed this review. However, targeting BCSC subpopulation presents challenges, including off-target effects, low solubility, bioavailability anti-BCSC agents. Nanoparticle-based offer promising approach target cellular processes implicated survival BSCS TNBC. In review, we explore nanocarrier-based approaches for BCSCs aiming overcome these improve outcomes patients. These nanoparticle-based therapeutic strategies hold promise addressing gap delivering while minimizing systemic toxicity enhancing efficacy. Graphical abstract

Language: Английский

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Advancements in Electrochemical Biosensing of Cardiovascular Disease Biomarkers

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(26), P. 6305 - 6327

Published: Jan. 1, 2024

Cutting-edge electrochemical biosensing techniques for detecting key cardiovascular disease biomarkers utilizing various technologies are explored.

Language: Английский

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CRISPR-Based Therapies: Revolutionizing Drug Development and Precision Medicine

Current Gene Therapy, Journal Year: 2024, Volume and Issue: 24(3), P. 193 - 207

Published: Feb. 4, 2024

With the discovery of CRISPR-Cas9, drug development and precision medicine have undergone a major change. This review article looks at new ways that CRISPR-based therapies are being used how they changing way is done. CRISPR technology's ability to precisely flexibly edit genes has opened up find, validate, develop targets. Also, it made for personalized gene therapies, precise editing, advanced screening techniques, all which hold great promise treating wide range diseases. In this article, we look latest research clinical trials show could be treat genetic diseases, cancer, infectious other hard-to-treat conditions. However, ethical issues problems with regulations also discussed in relation shows important use them safely responsibly. As continues change drugs used, shines light on amazing things been done what future might rapidly field.

Language: Английский

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Advancements in biosensors for cancer detection: revolutionizing diagnostics

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(3)

Published: Feb. 19, 2024

Language: Английский

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CRISPR/Cas systems for genomic Editing, biochemical Sensing, Bioanalysis, and diagnostics

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112638 - 112638

Published: Jan. 1, 2025

Language: Английский

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Review—Potential of Tunneling Magnetoresistance Coupled to Iron Oxide Nanoparticles as a Novel Transducer for Biosensors-on-Chip

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(1), P. 017512 - 017512

Published: Jan. 1, 2024

Biosensors-on-chip (BoC), compact and affordable public diagnostic devices, are vital for preventing health crises caused by viral bacterial mutations, climate change, poor diets. Clinical, remote, field use possible with these devices. BoC is used in food safety, environmental monitoring, medical diagnosis. The coupling of tunneling magnetoresistance (TMR) sensing elements chip form surface functionalized iron oxide nanoparticles (IONPs) as a biomarker, known TMR/ IONPs, allows devices to be made. functional framework based on the instrument system, biomolecule immobilization will covered this review. This review aims overview recent research biosensor using TMR technology IONPs biomarkers discuss its future advances point-of-care diagnostics. sensors have revolutionized low-magnetic technologies, yet biosensing faces challenges. However, it’s important recognize that exclusively utilize out-of-plane connections. creates larger separation between biomolecules layer, leading decrease sensitivity biomolecules. Large magnetization dispersed generate sufficient stray-field, inexpensive instrumentation sense low voltage yielded TMR/IONPs high-selectivity bio-analyte increase sensor notable issues address problem. utilization green synthesized method producing magnetic labeling can enhance TMR-based biosensor. achieved through formation capping agent inhibits aggregation facilitates target. Additionally, improving device performance requires creating high-TMR materials. Despite challenges, technological hold great promise TMR/GS-IONP bio-applications.

Language: Английский

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Advancing cancer therapy: Unveiling the cutting-edge potential of carmustine nano carriers for targeted treatment

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105943 - 105943

Published: July 4, 2024

Language: Английский

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Nano-engineered solutions for ibuprofen therapy: Unveiling advanced co-delivery strategies and nanoparticle systems

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105815 - 105815

Published: June 4, 2024

Language: Английский

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Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties

Phytomedicine, Journal Year: 2023, Volume and Issue: 122, P. 155150 - 155150

Published: Oct. 15, 2023

Language: Английский

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The importance of protein domain mutations in cancer therapy

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27655 - e27655

Published: March 1, 2024

Cancer is a complex disease that caused by multiple genetic factors. Researchers have been studying protein domain mutations to understand how they affect the progression and treatment of cancer. These can significantly impact development spread cancer changing structure, function, signalling pathways. As result, there growing interest in these be used as prognostic indicators for prognosis. Recent studies shown provide valuable information about severity patient's response treatment. They may also predict resistance targeted therapy The clinical implications are significant, regarded essential biomarkers oncology. However, additional techniques approaches required characterize changes domains their functional effects. Machine learning other computational tools offer promising solutions this challenge, enabling prediction on structure function. Such predictions aid interpretation information. Furthermore, genome editing like CRISPR/Cas9 has made it possible validate significance mutants more efficiently accurately. In conclusion, hold great promise predictive Overall, considerable research still needed better define molecular heterogeneity resolve challenges remain, so full potential realized.

Language: Английский

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