Polymeric
based
nanoparticles
are
garnering
significant
interest
for
their
potential
in
drug
delivery.
Specially,
nanopolymers
that
have
been
functionalized
with
molecules,
such
as
proteins
or
peptides,
a
versatile
vehicle
Curcumin
(Cur)
is
one
of
the
most
commonly
studied
anticancer
compounds
and
widely
acknowledged
having
positive
effects
on
human
health.
However,
its
insolubility
low
bio-distribution
greatly
hinder
exploitation
beneficial
traits.
In
this
study,
our
team
created
nano
delivery
system
which
utilized
nanopolymer
called
PCL-PEG
(poly(ε-caprolactone)-poly
(ethylene
glycol)).
This
was
A6
peptide
to
enable
targeted
Cur.
The
designed
advantageous
(NPs),
including
stable
zeta
(–32.7),
small
size
(54.3),
uniform
surface
morphology,
high
hydrophilicity
(13.72°).
addition,
systems
exhibited
encapsulation
efficacy
(93
±
0.89
%),
loading
(16.7
0.9
were
characterized
by
slow
gradual
release
profile
approximately
83.13
0.12%.
MTT
assay
results
showed
formulation
known
Cur-NPs-A6
caused
increase
cell
death
MDA-MB-231
cancer
cells
(IC50
=
23.31
0.85
µM).
did
not
cause
any
harm
noncancerous
MCF-10A
(normal
group).
Furthermore,
both
RT-qPCR
invasion
assays
demonstrated
able
effectively
activate
apoptosis
pathway
inhibit
invasion.
Our
findings
suggest
use
smart
system,
has
affinity
CD44
receptor
-
be
upregulated
numerous
malignant
conditions,
could
highly
efficient
approach
treating
cancer.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(1)
Published: Jan. 1, 2024
Abstract
Curcumin
is
a
natural
compound
derived
from
turmeric
and
can
target
malignant
tumor
molecules
involved
in
cancer
propagation.
It
has
potent
antioxidant
activity,
but
its
effectiveness
limited
due
to
poor
absorption
rapid
elimination
the
body.
Various
curcumin
derivatives
have
also
shown
anticancer
potential
in‐vitro
in‐vivo
models.
multiple
signaling
pathways
development/progression
or
induce
cell
death
through
apoptosis.
In
addition,
could
enhance
of
conventional
chemotherapy,
radiation
therapy
reduce
their
associated
side
effects.
Lately,
nanoparticle‐based
delivery
systems
are
being
developed/explored
overcome
challenges
with
curcumin's
delivery,
increasing
overall
efficacy.
The
use
an
imaging
system
track
these
formulations
give
beneficial
information
about
bioavailability
distribution
nano‐curcumin
complex.
conclusion,
holds
significant
promise
fight
against
cancer,
especially
nanoform,
provide
precise
cells
without
affecting
normal
healthy
cells.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Abstract
Colorectal
cancer
(CRC)
ranks
among
the
leading
causes
of
cancer‐related
dea
ths
worldwide,
and
rising
incidence
mortality
CRC
underscores
urgent
need
for
better
understanding
management
strategies.
Icaritin
(ICA)
is
metabolites
icariin,
a
natural
flavonoid
glycoside
compound
derived
from
stems
leaves
Epimedium
.
It
has
broad
spectrum
antitumor
activity
inhibits
proliferation,
migration,
invasion
cells,
S
phase
cell
cycle
arrest.
exerts
its
effects
against
through
repressing
autophagy
to
promote
apoptosis
via
interfering
HSP90‐TXNDC9
interactions.
The
safety
efficacy
ICA
are
also
affirmed
in
mouse
xenograft
model.
Additionally,
test
whether
synergistic
with
low‐temperature
photothermal
therapy
(LTPTT),
novel
nanodrug
delivery
system,
employing
SiO
2
nanocarriers,
designed
aiming
load
materials
polydopamine
(PDA),
folic
acid
(FA).
This
/Ica‐PDA‐FA
multifunctional
nanocomposite
actively
targets
tumor
tissues
high
affinity
FA
cells.
Once
internalized,
acidic
intracellular
environment
triggers
controlled
release
ICA,
inhibiting
By
LTPTT
drug
under
near‐infrared
illumination,
dual
effect
achieved,
holding
promise
enhancing
therapeutic
outcomes
treatment.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 15, 2023
At
present,
cancer
is
the
largest
culprit
that
endangers
human
health.
The
current
treatment
options
for
mainly
include
surgical
resection,
adjuvant
radiotherapy
and
chemotherapy,
but
their
therapeutic
effects
long-term
prognosis
are
unsatisfactory.
Immunotherapy
an
emerging
therapy
has
completely
transformed
landscape
of
advanced
cancers,
tried
to
occupy
a
place
in
neoadjuvant
resectable
tumors.
However,
not
all
patients
respond
immunotherapy
due
immunological
molecular
features
Traditional
Chinese
Medicine
(TCM)
provides
new
perspective
considered
have
potential
as
promising
anti-tumor
drugs
considering
its
immunoregulatory
properties.
This
review
concludes
commonly
used
TCM
monomers
compounds
from
immune
regulatory
pathways,
aiming
clearly
introduce
basic
mechanisms
boosting
several
common
TCM.
In
addition,
we
also
summarized
closed
ongoing
trials
presented
prospects
future
development.
Due
significant
role
non-small
cell
lung
(NSCLC),
combined
with
should
be
emphasized
NSCLC.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(20), P. 13694 - 13702
Published: Jan. 1, 2024
Currently,
the
photostability
of
photosensitizer
curcumin
is
main
bottleneck
limiting
their
application,
reducing
bioavailability
curcumin.
Studying
effect
different
light
sources
on
photostabilities
and
loading
it
onto
polydopamine
nanocarriers
with
better
biocompatibility
will
help
improve
its
utilization
efficiency.
In
this
study,
we
investigated
a
polydopamine-based
nanoparticle
(polydopamine-curcumin
composite
nanoparticles,
PDA-Cur
NPs)
loaded
through
in
vitro
vivo
experiments
to
achieve
antitumor
effects.
The
results
demonstrated
that
has
good
dark,
but
significant
photodegradation
rates
both
red
blue
light.
Blue
faster
curcumin,
degradation
rate
42.1%
after
10
minutes,
which
about
1.7
times
Our
study
successfully
synthesized
NPs,
demonstrating
ability
stably
load
release
percentage
65.7%
2
hours
41.9%
8
(pH
6.0).
Compared
single
treatments,
NPs
treatments
were
reduced
by
46%
50%,
respectively.
Meanwhile,
exhibited
remarkable
efficacy
due
PDT
promote
apoptosis
cancer
cells,
than
treatments.
Moreover,
MCF-7
tumor-bearing
mice,
led
tumor
growth
inhibition
effects,
without
causing
evident
systemic
damage
vivo.
findings
highlight
potential
as
anticancer
greatly
increased
PDT.
World Journal of Hepatology,
Journal Year:
2024,
Volume and Issue:
16(2), P. 164 - 176
Published: Feb. 27, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
liver
cancer
and
poses
a
major
challenge
to
global
health
due
its
high
morbidity
mortality.
Conventional
chemotherapy
usually
targeted
patients
with
intermediate
advanced
stages,
but
it
often
ineffective
suffers
from
problems
such
as
multidrug
resistance,
rapid
drug
clearance,
nonspecific
targeting,
side
effects,
low
accumulation
in
tumor
cells.
In
response
these
limitations,
recent
advances
nanoparticle-mediated
delivery
technologies
have
emerged
breakthrough
approaches
for
treatment
of
HCC.
This
review
focuses
on
nanoparticle-based
systems,
special
attention
various
receptors
overexpressed
HCC
These
are
key
enhancing
specificity
efficacy
nanoparticle
represent
new
paradigm
actively
targeting
combating
We
comprehensively
summarize
current
understanding
receptors,
their
role
impact
therapies
By
gaining
deeper
receptor-mediated
mechanisms
innovative
therapies,
more
effective
precise
can
be
achieved.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 207 - 207
Published: Feb. 12, 2025
The
term
“oxidative
stress”
refers
to
an
imbalance
between
reactive
oxygen
species
(ROS)
generation
and
the
antioxidant
system,
resulting
in
increased
formation
of
ROS
reduced
and/or
inadequate
efficiency
physiological
processes
responsible
for
their
elimination
homeostasis
maintenance
[...]
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
The
advancement
in
exclusively
tailored
therapeutic
delivery
systems
has
escalated
a
great
deal
of
interest
targeted
to
augment
efficacy
and
lessen
adverse
effects.
approach
promisingly
helps
surmount
the
unmet
clinical
needs
conventional
therapies,
including
chemoresistance,
limited
penetration,
side
In
case
melanoma,
various
receptors
were
overexpressed
on
tumor
site,
among
which
folate
receptor
(FR)
targeting
is
considered
be
progressive
for
managing
melanoma.
FRs
are
macromolecules
glycosyl
phosphatidylinositol-attached
protein
that
possess
globular
assembly
with
greater
affinity
toward
specific
ligands.
So,
functional
ligands
can
utilized
design
nanocarriers
(NCs)
effectively
bind
FRs.
Hence,
folate-adorned
NCs
(FNCs)
offer
benefits
such
as
site-specific
targeting,
cargo
protection,
minimizing
toxicity.
This
review
focuses
insights
implications
FRs,
mechanisms,
challenges,
advantages
FNCs.
Further,
applications
FNCs,
liposomes,
polymeric
NCs,
albumin
nanoparticles,
inorganic
liquid
crystalline
nanogels,
have
been
elaborated
melanoma
therapy.
Likewise,
potential
FNCs
immunotherapy,
photodynamic
therapy,
chemotherapy,
gene
photothermal
imaging
exhaustively
discussed.
Furthermore,
translational
hurdles
solutions
discussed
detail.
present
expected
give
thoughtful
ideas
researchers,
industry
stakeholders,
formulation
scientists
efficacious
development
