Water,
Journal Year:
2022,
Volume and Issue:
14(9), P. 1357 - 1357
Published: April 22, 2022
Diazinon
(DZN)
is
a
widely
used
pesticide
that
can
affect
the
vital
organs
of
non-target
aquatic
animals—mainly
fish.
This
study
evaluated
acute
toxicity
(LC50)
six
DZN
concentrations
(0.5,
0.75,
1.5,
2,
2.5,
and
3
mg·L−1)
and,
based
on
its
evaluation
after
24
h,
48
72
96
two
sublethal
for
chronic
testing
(0.01
0.05
21
days
exposure
to
grass
carp
fingerlings
(Ctenopharyngodon
idella
Valenciennes,
1844).
The
median
lethal
at
24,
48,
72,
h
were
1.83,
1.57,
1.35,
1.12
mg·L−1,
respectively.
Next,
histological
observations
LC50
showed
oedema
primary
lamellae
gills
low
(0.5
1
extensive
necrosis
higher
(1.5
mg·L−1).
Moreover,
cytoplasmic
vacuolation
observed
in
liver
tissue.
Increased
skin
mucus,
unbalanced
swimming
water
surface,
increased
gill
opercula
movements
noted
during
exposure.
Haematological
parameters
such
as
haematocrit,
red
blood
cell
count,
white
haemoglobin,
mean
corpuscular
volume
significantly
reduced
mg·L−1
DNZ
(p
<
0.05).
present
shows
has
various
toxic
effects
carp,
which
may
pose
potential
risk
other
fish
species.
Reviews in Aquaculture,
Journal Year:
2020,
Volume and Issue:
12(4), P. 2511 - 2526
Published: June 18, 2020
Abstract
Aquatic
organisms
are
susceptible
throughout
their
lives
to
chemical
and
physical
stressors,
which
negatively
affect
health.
Various
aquatic
pollutants
derived
from
industrial
effluents,
overuse
of
some
agricultural
pesticides,
herbicides
insecticides
may
cause
devastating
toxicological
aspects
deteriorate
health
growth.
They
also
led
oxidative
stress
fish
due
the
stimulation
production
reactive
oxygen
species.
Therefore,
need
for
using
natural
antioxidants
be
used
as
feed
additives
is
great
importance
counteract
hazardous
responses.
The
use
phytochemicals,
characterized
by
substantial
antioxidative
effects,
has
been
raised.
Lycopene
principal
carotenoid
pigment
found
in
tomatoes
products,
vegetables
red
fruits.
Numerous
studies
have
recommended
lycopene
a
powerful
antioxidant
attenuate
responses
several
species
exposed
various
toxicants
or
any
other
conditions.
maintains
condition
enhancing
immune
This
review
article
aimed
elucidate
current
information
about
potential
dietary
its
capability
haemato‐immunological
alterations
resulted
environmental
stressors.
Additionally,
discusses
regarding
mode
action
assess
profits
that
would
aquaculture
industry.
Ecotoxicology and Environmental Safety,
Journal Year:
2021,
Volume and Issue:
216, P. 112227 - 112227
Published: April 11, 2021
Difenoconazole
(DIF),
a
common
broad-spectrum
triazole
fungicide,
is
associated
with
an
increased
risk
of
cardiovascular
diseases.
Unfortunately,
little
attention
has
been
paid
to
the
mechanisms
underlying
this
association.
In
study,
zebrafish
embryos
were
exposed
DIF
(0,
0.3,
0.6
and
1.2
mg/L)
from
4
96
h
post
fertilization
(hpf)
toxicity
was
evaluated.
Our
results
showed
that
decreased
hatching
rate,
survival
rate
heart
malformation
rate.
Cardiovascular
deformities
are
most
prominent,
including
pericardial
edema,
abnormal
cardiac
structure
disrupted
vascular
pattern
in
two
transgenic
models
(myl7:egfp
fli1:egfp).
exacerbated
oxidative
stress
by
via
accumulation
reactive
oxygen
species
(ROS)
inhibition
antioxidant
enzyme.
apoptosis
triggered
through
expression
p53,
bcl-2,
bax
caspase
9,
while
suppressed
transcription
key
genes
involved
calcium
signaling
muscle
contraction.
These
adverse
outcomes
restored
N-acetyl-L-cysteine
(NAC),
indicating
played
crucial
role
DIF-induced
caused
Taken
together,
study
revealed
provided
novel
insights
into
strategies
mitigate
its
toxicity.
The Science of The Total Environment,
Journal Year:
2021,
Volume and Issue:
775, P. 145671 - 145671
Published: Feb. 16, 2021
Fenitrothion
is
an
organophosphorus
insecticide
usually
found
in
aquatic
ecosystems
at
concentrations
the
range
of
low
ng/L.
In
this
manuscript
we
show
that
24
h
exposure
to
environmental
fenitrothion,
from
ng/L
μg/L,
altered
basal
locomotor
activity,
visual-motor
response
and
acoustic/vibrational
escape
zebrafish
larvae.
Furthermore,
fenitrothion
expression
gap43a,
gfap,
atp2b1a,
mbp
exhibited
a
significant
non-monotonic
concentration-response
relationship.
Once
determined
were
neurotoxic
for
larvae,
computational
analysis
identified
potential
protein
targets
compound.
Some
predictions,
including
interactions
with
acetylcholinesterase,
monoamine-oxidases
androgen
receptor
(AR),
experimentally
validated.
Binding
AR
was
most
suitable
candidate
molecular
initiating
event,
as
indicated
by
both
up-regulation
cyp19a1b
sult2st3
relationship
between
observed
responses.
Finally,
when
integrity
monoaminergic
system
evaluated,
levels
L-DOPA,
DOPAC,
HVA
5-HIAA
found,
well
slc18a2
lowest
fenitrothion.
These
data
strongly
suggest
commonly
present
risk
fish
communities.
