Exposure to the plasticizer diisopentyl phthalate can cause Vero cell line death DOI

Ana Catharina Moscardi,

Ana Carolina Irioda,

Bassam Felipe Mogharbel

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 186, P. 114521 - 114521

Published: Feb. 16, 2024

Language: Английский

Antioxidants in Mitigating Phthalate-Induced Male Reproductive Toxicity: A Comprehensive Review DOI
Shirsha Mondal, Arindam Bandyopadhyay

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143297 - 143297

Published: Sept. 1, 2024

Language: Английский

Citations

7
Active binding mechanism to superoxide dismutase and toxicological implication for environmentally prevalent phthalates and their hydrolytic products: Coupling in vitro bioassay with molecular dynamics simulation DOI

Xiuli Fan,

Chenggang Gu, Zhengyuan Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143607 - 143607

Published: April 1, 2025

Language: Английский

Citations

0
Evaluation of precopulatory pairing behaviour and male fertility in a marine amphipod exposed to plastic additives DOI Creative Commons
Bidemi Green-Ojo, Marina Tenório Botelho, Gisela de Aragão Umbuzeiro

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 341, P. 122946 - 122946

Published: Nov. 15, 2023

Plastics contain a mixture of chemical additives that can leach into the environment and potentially cause harmful effects on reproduction endocrine system. Two these chemicals, N-butyl benzenesulfonamide (NBBS) triphenyl phosphate (TPHP), are among top 30 organic chemicals detected in surface groundwater currently placed international watchlist for evaluation. Although bans have been legacy pollutants such as diethylhexyl phthalate (DEHP) dibutyl (DBP), their persistence remains concern. This study aimed to examine impact plastic additives, including NBBS, TPHP, DBP, DEHP, reproductive behaviour male fertility marine amphipod Echinogammarus marinus. Twenty precopulatory pairs E. marinus were exposed varying concentrations four test assess pairing behaviour. A high-throughput methodology was developed optimised record contact time re-pair within 15 min additional point observations 96 h. The found low levels DEHP prolonged re-pairing amphipods proportion reduced drastically with success ranging from 75% 100% control group 0%–85% groups at Sperm count declined by 40% 60% 50 μg/l 500 DBP groups, respectively, whereas TPHP resulted significantly lower sperms group. Animals NBBS showed high interindividual variability all groups. Overall, this provides evidence disrupt mechanisms sperm counts environmentally relevant concentrations. Our research also demonstrated usefulness mechanism sensitive endpoint ecotoxicity assessments proactively mitigate population-level aquatic environment.

Language: Английский

Citations

10
Carvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic properties DOI
Ahmet Uyar, Mustafa Cellat, Özgür Kanat

et al.

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 121, P. 108456 - 108456

Published: Aug. 14, 2023

Language: Английский

Citations

7
Preparation of novel magnetic ethylene glycol dimethacrylate-based molecularly imprinted polymer for rapid adsorption of phthalate esters from ethanol aqueous solution DOI
Yuanhao Zhou, Shunying Li,

Xiaoya Sun

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 361, P. 124891 - 124891

Published: Sept. 4, 2024

Language: Английский

Citations

2
Energy metabolism and spermatogenesis DOI Creative Commons
Damilare Rotimi, Matthew Iyobhebhe, Elizabeth Temidayo Oluwayemi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38591 - e38591

Published: Sept. 27, 2024

Language: Английский

Citations

2
Glucose transporters (GLUTs): Underreported yet crucial molecules in unraveling testicular toxicity DOI
Shirsha Mondal, Arindam Bandyopadhyay

Biochimie, Journal Year: 2023, Volume and Issue: 219, P. 55 - 62

Published: Nov. 13, 2023

Language: Английский

Citations

4
Dibutyl phthalate disrupts glycogen synthase kinase 3α essential for sperm motility DOI Creative Commons
Seung Hyun Park, Myung Chan Gye

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 115977 - 115977

Published: Jan. 19, 2024

To unravel the toxic mechanism of phthalate ester plasticizer endocrine disruptor in spermatozoa, we examined effect dibutyl (DBP) on stability and inhibitory phosphorylation glycogen synthase kinase 3α (GSK3α), a protein crucial for sperm motility mice. In DBP-treated reactive oxygen species (ROS) lipid peroxide were significantly increased. computer-assisted analysis, DBP at concentrations 10 – 100 μg/mL decreased total progressive spermatozoa. On western blots, p-GSK3α(Ser21) increased p-GSK3α(Tyr279) Similarly, hydrogen but not Immunofluorescent labeling demonstrated that markedly immunoreactivities GSK3α immunoreactivity concentration phosphatase activity Calyculin A, 1 2 A inhibitor, attenuated DBP-induced decrease motility. blot, 1–100 immunoprecipitation - polyubiquitinated proteins including GSK3α. The MG115, proteasome inhibitor degradation Hydrogen μM proteins, suggesting may increase ubiquitination via ROS induction. Together, cellular amount through ubiquitin-proteasome pathway generation activation phosphatases, impairing

Language: Английский

Citations

1
Dimethyl phthalate exposure induces cognitive impairment through COX2-mediated microglial activation DOI Creative Commons
Genghuan Wang, Jian Shen,

Yingcong Lin

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 20, 2024

Abstract AIM We investigated the mechanism of action whereby exposure to dimethyl phthalate (DMP), an environmental pollutant, causes cognitive impairment. METHODS Network pharmacology was used analyze targets and regulatory networks associated with DMP-brain injury-cognitive The intake DMP simulated by exposure, Morris water maze adopted examine tissue levels inflammatory cytokines were detected. Brain damage assayed H&E Nissl staining, protein expression identified Western blotting. effects observed after separate application siRNA-COX2 celecoxib-COX2 inhibitors. In in vitro experiment, on microglia activation investigated. RESULTS revealed that PTGS2 (COX2) significantly correlated DMP, which could act through COX2. After mice showed significant brain injury impairment, along upregulation cytokines. inhibit ameliorate impairment mice. results activate cause neuroinflammation. CONCLUSION can induce neuroinflammation COX2-mediated microglia, resulting COX2 is important target for action.

Language: Английский

Citations

1
BISFENOL A: UMA AMEAÇA AOS HORMÔNIOS SEXUAIS DOI Open Access

Sara Catarina Pereira,

Vanessa Staldoni de Oliveira, Rúben Moreira

et al.

Editora Reflexão Acadêmica eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 70 - 92

Published: March 15, 2024

Masters, 16 PhD, 12 pos-doc and more than 66 undergraduate students with CNPq fellowship for Scientific Initiation.As research experience, develop studies in Pharmacy related to Pharmacognosy Medicinal Chemistry.Studies are focused on effect mechanism of action hormones, natural synthetic compounds toxicants diabetes male reproduction fertility.

Language: Английский

Citations

0