Indian Journal of Experimental Biology,
Journal Year:
2023,
Volume and Issue:
61(10)
Published: Sept. 29, 2023
Population
explosion
and
simultaneous
rapid
loss
of
cultivable
land
escalated
the
use
pesticides
herbicides
to
ensure
food
security.
However,
uncontrolled
application
toxic
pesticides/herbicides,
particularly
organophosphorus
sulfonylurea,
has
resulted
in
increased
mortality
morbidity
worldwide.
The
present
study
reports
neurotoxic
effect
Excel
Mera
71
Almix
based
on
brain
histopathology
Asian
stinging
fish,
Heteropneustes
fossilis
(Bloch).
Herbicides,
(17.2
mg/L)
(66.67
were
administered
fish
for
30
days.
Study
showed
several
endpoints
optic
tectum
with
varying
degree.
Spongiosis,
binucleated
nuclei,
congestion,
necrosis,
enlarged
pyramidal
cells
(EPC),
neuronal
degeneration,
vacuolization,
gliosis,
aberrant
horizontal
cell
orientation
granular
prominent
pathological
symptoms
Almix-treated
H.
fossilis.
Among
six
layers,
SPV
(stratum
periventriculare)
SAC
album
centrale)
layer
maximally
impacted
by
herbicide
exposure.
Appearance
neural
vacuolization
Nissl
substances,
collectively
called
neurotoxicity
indicators,
very
under
treatment.
Higher
prevalence
these
lesions
indicated
that
this
higher
potential
than
Almix.
Additionally,
mean
assessment
value
(MAV)
highest
(4.06
±
0.02),
followed
(3.28
0.10)
compared
control
(0.09
0.04).
Collectively,
alterations
both
caused
adverse
effects
metabolism
including
sensory
modalities,
visual
appearances,
motor
coordination.
Accordingly,
changes
can
be
utilized
as
biomarker
evaluating
environmental
toxicants.
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
469, P. 133935 - 133935
Published: March 1, 2024
Bisphenol
A
(BPA)
and
its
various
forms
used
as
BPA
alternatives
in
industries
are
recognized
toxic
compounds
antiandrogenic
endocrine
disruptors.
These
chemicals
widespread
the
environment
frequently
detected
biological
samples.
Concerns
exist
about
their
impact
on
hormones,
disrupting
natural
processes
humans,
together
with
negative
impacts
biotic
life.
This
study
aims
to
characterize
interaction
between
analogs
androgen
receptor
(AR)
effect
receptor's
normal
activity.
To
achieve
this
goal,
molecular
docking
was
conducted
dihydrotestosterone
(DHT)
a
reference
ligand.
Four
exhibited
higher
affinity
(−10.2
−8.7
kcal/mol)
for
AR
compared
(−8.6
kcal/mol),
displaying
distinct
patterns.
Interestingly,
DHT
(−11.0
shared
binding
pattern
BPA.
ADMET
analysis
of
top
10
compounds,
followed
by
dynamics
simulations,
revealed
toxicity
dynamic
behavior.
Experimental
studies
demonstrated
that
only
disrupts
DHT-induced
dimerization,
thereby
affecting
AR's
function
due
nature.
similarity
observed
during
computational
analysis.
findings
emphasize
importance
targeted
strategies
mitigate
toxicity,
offering
crucial
insights
interventions
human
health
environmental
well-being.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(7), P. e28419 - e28419
Published: March 27, 2024
The
study
examined
the
potential
of
Silymarin,
a
blend
bioactive
flavonolignans
extracted
from
milk
thistle
Silybum
marianum,
to
mitigate
Deltamethrin-induced
toxicity
in
blood
Cyprinus
carpio.
Fish
were
exposed
Deltamethrin
(0.66
μg/L),
plant
extract,
or
combination
both
for
duration
thirty
days.
Various
parameters,
including
serum
biochemical
markers,
erythrocytic
abnormalities,
and
genotoxicity
endpoints,
assessed.
Results
indicated
significant
(p
<
0.05)
increase
levels
AST,
ALT,
ALP,
urea
nitrogen,
creatinine,
glucose,
cholesterol,
TLC
fish
pesticide.
Conversely,
total
protein,
TEC,
Hb
showed
notable
decrease.
There
was
also
rise
micronuclei
abnormalities
such
as
acanthocytes,
microcytes,
notched
cells.
Under
ultrastructural
examination,
phenotypic
deformities
like
spherocytosis,
discocytes,
clumped
erythrocytes
observed.
However,
dietary
supplementation
silymarin
(1
g/kg)
significantly
restored
biochemical,
genetic,
cellular
resembling
those
control
group.
This
suggests
this
extract
protecting
common
carp,
carpio,
damage
by
scavenging
free
radicals
reducing
DNA
oxidative
stress.
Frontiers in Toxicology,
Journal Year:
2025,
Volume and Issue:
7
Published: April 16, 2025
Deltamethrin
is
a
pyrethroid
insecticide
commonly
used
to
kill
animal
parasites
in
aquaculture.
However,
increasing
evidence
suggests
that
deltamethrin
affects
the
health
of
aquatic
animals
by
causing
tissue
damage
and
even
death.
In
this
study,
caused
gill
liver
tissues,
as
well
its
effects
on
oxidative
stress
immune
metabolism,
were
studied
Paralichthys
olivaceus.
We
observed
positive
correlation
between
residual
levels
(Del)
exposure
concentrations,
with
highest
residue
detected
0.28
μg/L
concentration
group
(0.0684
mg/kg
at
7
days).
Then,
we
different
degrees
tissues
olivaceus,
including
swelling,
apical
fusion,
shedding
secondary
lamellae,
cell
necrosis,
nuclear
vacuolization,
observing
sections.
Lysozyme
enzyme
activity
increased,
whereas
catalase
alkaline
phosphatase
activities
decreased.
The
transcriptome
results
control
high-concentration
(0.28
μg/L)
groups
showed
there
697
differentially
expressed
genes,
390
upregulated
307
downregulated
genes.
These
genes
significantly
enriched
oxidation-reduction,
ferroptosis,
steroid
biosynthesis,
apoptosis
pathways.
summary,
found
induces
metabolic
disorders
P.
olivaceus
leads
inflammation.
fish
body
resists
such
through
complex
regulatory
network.
experimental
provide
theoretical
reference
for
safe
use
