Toward In Vitro Vascular Wall Models: Digital Light Processing of Acrylate‐Endcapped Urethane‐Based Polymers into Tubular Constructs DOI Open Access
Nele Pien, Ianina Pokholenko, Nicolas Deroose

et al.

Macromolecular Chemistry and Physics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Digital light processing (DLP) is emerging as a powerful tool for fabricating tissue engineering (TE) scaffolds, particularly vascular TE and the development of representative in vitro wall models. For latter, biomaterials should mimick biological mechanical properties native blood vessels. To fabricate tubular constructs, DLP‐printing process optimized by exploiting acrylate‐endcapped urethane‐based (AUP) polymers presence acrylate end groups render them suitable DLP printing desirable arise from urethane segments. Four AUP variants are synthesized, exploring polyethylene glycol (PEG) polypropylene (PPG) backbones with varying functionalities (di‐acrylate versus hexa‐acrylate), namely UPEG2, UPEG6, UPPG2, UPPG6. Tubular constructs precise dimensions morphology fabricated. PPG‐based exhibit superior computer‐aided design/manufacturing (CAD/CAM) mimicry compared to PEG‐based derivatives. Construct characterization reveals tunable properties, elastic moduli ranging 45 259 kPa, reaching values human In particular, UPPG6 shows two‐fold higher modulus UPPG2. All materials show excellent biocompatibility. Additionally, surface modification gelatin‐methacryloyl (GELMA) significantly enhances cytocompatibility UPPG2 scaffolds. This study demonstrates feasibility using polymers.

Language: Английский

Emerging adsorbents: Applications of sodium alginate/graphene oxide composite materials in wastewater treatment DOI

Huishuang Li,

Xiaoguang Zhu,

Jiuhong Zhao

et al.

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 59, P. 105100 - 105100

Published: March 1, 2024

Language: Английский

Citations

17
Double-Network Hydrogel with Strengthened Mechanical Property for Controllable Release of Antibacterial Peptide DOI

Tingyuan Tan,

Yangqian Hou, Yi Zhang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(3), P. 1850 - 1860

Published: Feb. 28, 2024

Developing double-network (DN) hydrogels with high mechanical properties and antibacterial efficacy to combat multidrug-resistant bacterial infections serve as scaffolds for cell culture still remains an ongoing challenge. In this study, ion-responsive peptide (AMP) (C16-WIIIKKK, termed IK7) was synergistically combined a photoresponsive gelatin methacryloyl (GelMA) polymer fabricate biocompatible DN hydrogel. The GelMA-IK7 hydrogel showed enhanced in contrast the individual IK7 GelMA demonstrated substantial efficacy. Further investigations revealed that effectively inhibited growth by controlled sustained release of peptide. addition, formation also found protect AMP from rapid degradation proteinase K. Our findings suggested developed holds great potential next-generation three-dimensional tissue regeneration.

Language: Английский

Citations

10
A Bioactive Gelatin-Methacrylate Incorporating Magnesium Phosphate Cement for Bone Regeneration DOI Creative Commons
Xiping Zhang,

Changtian Gong,

Xingyu Wang

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 228 - 228

Published: Jan. 19, 2024

Maintaining proper mechanical strength and tissue volume is important for bone growth at the site of a defect. In this study, potassium magnesium phosphate hexahydrate (KMgPO4·6H2O, MPC) was applied to gelma-methacrylate hydrogel (GelMA) prepare GelMA/MPC composites (GMPCs). Among these, 5 GMPC showed best performance in vivo vitro. These combinations significantly enhanced GelMA regulated degradation absorption rate MPC. Considerably better properties were noted compared with other concentrations. Better bioactivity osteogenic ability also found GMPC. Magnesium ions (Mg2+) are bioactive proven promote regeneration, which enhancement efficiency closely related Mg2+ findings indicated that GMPCs can release effective treatment defects hold promise future applications.

Language: Английский

Citations

4
A review of the current state of the art in gelatin methacryloyl-based printing inks in bone tissue engineering DOI Creative Commons

Mihaela-Raluca Dobrișan,

Adriana Lungu, Mariana Ioniţă

et al.

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: July 22, 2024

Achieving efficient scaffolds for bone tissue engineering (TE) requires smartly defined parameters reaching a balance between physical–chemical properties, biocompatibility and complex architectures. Three-dimensional (3D) printing offers precise geometry control of the desired scaffold at micro-scale. However, performance 3D is highly dependent on formulation, challenge being to achieve suitable ink establish most parameters. Gelatin methacryloyl (GelMA) emerges as promising due superior biological photocrosslinking ability printability. The present review focuses evolution GelMA-based inks bioinks from simplest advanced multicomponent formulations capable regeneration. Additionally, comparative analysis different photoinitiators covered, indicating each one's advantages disadvantages. Furthermore, main bioprinting methods that are used in GelMA outlined with required their influence final product performance.

Language: Английский

Citations

4
From fabrication to function: Mechanical insights into GelMA microneedle arrays DOI Creative Commons

Moloud Amini Baghbadorani,

Masoumeh Zargar, Asghar Eskandarinia

et al.

Smart Materials in Manufacturing, Journal Year: 2025, Volume and Issue: 3, P. 100083 - 100083

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dual Crosslinkable Gelatin Glycidyl Methacrylate-based Hydrogel: Key Insights to Biophysical Properties and Applicability Towards 3D Printing DOI

Garga Mondal,

Sulob Roy Chowdhury,

Priyanka Paul

et al.

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Current Status of Research on Biomimetic Hydrogels for Articular Cartilage DOI

Kuishun Ma,

Fei Wang,

Tingxin Liang

et al.

Journal of Bionic Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
A review of self-healing hydrogels for bone repair and regeneration: Materials, mechanisms, and applications DOI
Bo Li,

Chenchen Li,

Ziyi Yan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138323 - 138323

Published: Dec. 1, 2024

Language: Английский

Citations

3
Synthesis and characterization of gelatin-based quaternizable hydrogels DOI Open Access
Merve Bat Özmatara,

Merve Özpolat,

Tuğçe Nihal Gevrek

et al.

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Journal Year: 2025, Volume and Issue: 27(1), P. 228 - 240

Published: Jan. 20, 2025

Gelatin, a water-soluble natural polymer with excellent film-forming properties, exhibits high biocompatibility due to its amino acid composition, which closely resembles that of proteins. However, gelatin has poor mechanical properties and poses risk bacterial infection when films are composed solely gelatin. In this study, gelatin-based crosslinked polymers quaternary amine groups, exhibiting potential antibacterial were developed. To achieve this, was first modified methacrylate via an isocyanate-amine reaction, the resulting material characterized using Fourier-transform infrared spectroscopy (FTIR) nuclear magnetic resonance (NMR). Hydrogels successfully synthesized by photopolymerization methacryloyl, tertiary amine-containing monomer four-arm crosslinker, FTIR, scanning electron microscope (SEM), thermogravimetric analysis (TGA). Subsequently, hydrogel prepared as film on glass surface, quaternization groups imparted polycationic coatings, enabling further investigation into their potential.

Language: Английский

Citations

0
Photo-cross-linked Hydrogels for Cartilage and Osteochondral Repair DOI
Yue Zhu, Jialin Chen, Haoyang Liu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(12), P. 6567 - 6585

Published: Nov. 13, 2023

Photo-cross-linked hydrogels, which respond to light and induce structural or morphological transitions, form a microenvironment that mimics the extracellular matrix of native tissue. In last decades, photo-cross-linked hydrogels have been widely used in cartilage osteochondral tissue engineering due their good biocompatibility, ease fabrication, rapid situ gel-forming ability, tunable mechanical degradable properties. this review, we systemically summarize different types physicochemical properties (including materials photoinitiators) explore biological modulated through incorporation additives, including cells, biomolecules, genes, nanomaterials, into hydrogels. Subsequently, compile applications with specific focus on repair. Finally, current limitations future perspectives are also discussed.

Language: Английский

Citations

7