ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
is the primary cause of gastric adenocarcinoma, which afflicts more than half world's population and seriously affects human health. However, achieving efficient treatment
Language: Английский
Precision medicine and engineering., Journal Year: 2024, Volume and Issue: 1(1), P. 100001 - 100001
Published: July 28, 2024
Stimulus-responsive hydrogels can undergo controllable shape deformation and exhibit sol-gel transition behavior under stimulus signals such as pH, reactive oxygen species (ROS), heat, light. Polysaccharides have become ideal candidates for constructing stimulus-responsive due to their biocompatibility biodegradability. The diversity of molecular weights functional groups polysaccharides allows them self-assemble or cooperate with other materials obtain through physical chemical crosslinking. Bioactive ingredients nanomaterials be conveniently encapsulated in the hydrogel matrix meet various requirements. polysaccharide-based are widely used biomedical field, especially fields drug delivery, tissue engineering, biosensors, imaging. In this review, design strategies recent research advances stimuli-responsive summarized. Future challenges also presented, review will guide study polysaccharide hydrogels.
Language: Английский
Citations
7
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 5553 - 5565
Published: July 23, 2024
Chirality plays a crucial role in the self-assembly of biomolecules nature. Peptides show chirality-dependent conformation and self-assembly. Lipidation peptides occurs vivo has recently been exploited designed conjugates to drive enhance bioactivity. Here, library pH-responsive homochiral heterochiral lipidated tripeptides designed. The lipopeptides comprise C16–YKK or C16–WKK (where all amino acids are l-isomers), two C16–Ykk C16–Wkk lysines d-isomers). synthesized aqueous solution was examined using combination spectroscopic methods along with cryogenic-transmission electron microscopy (cryo-TEM) small-angle X-ray scattering (SAXS). Interestingly, it observed that at acidic pH self-assemble into micelles, whereas basic nanofibers, nanotapes nanotubes. A switch demonstrated thioflavin T fluorescence probe β-sheet structure present extended structures 8. We demonstrate both chirality influence behavior model tripeptides, which also promising Good cytocompatibility is hemolytic assays antimicrobial activity against Gram-negative Gram-positive bacteria shown through determination minimum inhibition concentration (MIC) bactericidal (MBC) values live/dead staining assay.
Language: Английский
Citations
6
Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 495 - 495
Published: July 26, 2024
Bacterial infection treatment for chronic wounds has posed a major medical threat and challenge. Bacteria at the wounded sites can compete with immune system subsequently invade live tissues, leading to more severe tissue damage. Therefore, there is an urgent demand wound dressings antibacterial anti-inflammatory properties. Considering concept of moist healing, hydrogels three-dimensional (3D) network structure are widely used as due their excellent hydrophilicity, water retention properties, biocompatibility. Developing infected been receiving extensive attention recently. This article categorizes according materials modes, introduces recent findings progress regarding status. More importantly, development emerging technologies, new therapies utilized prepare such nanoenzymes, photothermal therapy (PTT), photodynamic (PDT), metal–organic frameworks (MOFs), other external stimuli-responsive methods. this review also examines progress, challenges, future trends dressings. In following studies, will still be focus on that have high performance, multi-functions, intelligence, especially biocompatibility, long-lasting property, responsiveness, on-demand therapeutic ability.
Language: Английский
Citations
6
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
A series of tripodal (three-arm) lysine-based peptides were designed and synthesized their self-assembly properties in aqueous solution antimicrobial activity investigated. We compare the behaviors homochiral (KKY)3K a homologue containing bulky aromatic fluorenylmethoxycarbonyl (Fmoc) group Fmoc-(KKY)3K, heterochiral analogues k (d-Lys), (kkY)3K Fmoc-(kkY)3K. The molecular conformation solutions probed using various spectroscopic techniques, along with small-angle X-ray scattering (SAXS) cryogenic-transmission electron microscopy (cryo-TEM). In cell viability assays fibroblast lines, without Fmoc observed to be noncytotoxic over concentration range studied, functionalized only cytotoxic at highest concentrations (above critical aggregation lipopeptides). molecules also show good hemocompatibility sufficiently low concentration, was assessed via MIC (minimum inhibitory concentration) MBC bactericidal assays. These revealed that Fmoc-functionalized had significant against both Gram-negative Gram-positive bacteria, case Staphylococcus aureus, for Fmoc-(kkY)3K improved compared polymyxin B. mechanism assay found involve rupture bacterial membrane as evident from fluorescence live/dead assays, scanning images.
Language: Английский
Citations
0
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: March 29, 2025
As the clinical prevalence of antibiotic-resistant bacteria rises, effectiveness antibacterial drugs has been greatly reduced, hence, it is essential to create novel materials for combating bacterial infections. In recent years, antimicrobial peptides (AMPs) have demonstrated significant promise in addressing infections caused by bacteria, but as a natural product, they are limited terms activity and stability, cannot exert their full effect. The conjugation peptide-based biomaterials makes up this shortcoming, also improved, which lays foundation its application. This review aims introduce current progress AMPs-based treatment multidrug-resistant infections, covering topics from sources delivery combining biomaterial AMPs. addition, therapeutic advantages, including synergistic treatment, improved stability effectiveness, high biocompatibility, discussed. Finally, situation prospects AMP-based summarized.
Language: Английский
Citations
0
Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 25(1)
Published: Sept. 4, 2024
Abstract Wound dressings play a crucial role in wound management by providing protective barrier and creating an optimal environment for healing. Photocrosslinkable hydrogels, such as gelatin methacrylate (GelMA), have gained attention their unique properties but often lack antimicrobial activity. To enhance effectiveness, researchers are exploring methods to incorporate agents into photocrosslinkable hydrogel dressings. Immobilization of peptides (AMPs) onto matrices may be achieved through physical or chemical methods. Although, immobilization, using techniques like EDC/NHS chemistry, has shown promise enhancing the capacity immobilization limited structure hydrogel. Physical methods, immersing, offer alternatives different efficacy biocompatibility. The study aims chemically immobilize GelMA with P9‐4 AMP photoinduced conjugation chemistry compare its method. Chemical significantly enhances effect hydrogels against multi‐drug resistant Psuedomonas aeruginosa (MDR P. ) methicillin‐resistant Staphylococcus aureus (MRSA) while maintaining favorable Study highlights potential AMP‐functionalized advanced reducing infections caused antibiotic‐resistant bacteria offers promising approach future research management.
Language: Английский
Citations
2
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156155 - 156155
Published: Sept. 1, 2024
Language: Английский
Citations
1
Journal of Polymer Research, Journal Year: 2024, Volume and Issue: 31(11)
Published: Nov. 1, 2024
Language: Английский
Citations
1
Polymer, Journal Year: 2024, Volume and Issue: 317, P. 127913 - 127913
Published: Dec. 9, 2024
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
is the primary cause of gastric adenocarcinoma, which afflicts more than half world's population and seriously affects human health. However, achieving efficient treatment
Language: Английский
Citations
0