ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(43), P. 58973 - 58979
Published: Oct. 18, 2024
Maximizing
the
molecular
information
density
requires
simultaneously
functionalizing
distinct
monomers
and
their
coupling
connections.
However,
current
synthesis
generally
focuses
on
rather
than
reactions
because
multistep
significantly
escalate
synthetic
complexity
in
an
exponential
increase.
Here,
we
report
two-dimensional
nanoarchitectures
(2DNs)
of
end-on
oligomers,
with
versatile
structures
negative
differential
resistance
(NDR),
synthesized
by
programmed
surface-initiated
step
electrosynthesis
based
simultaneous
utilization
six
including
cross-
homocouplings.
The
resulting
vertically
similar
values
thickness
length,
as
crystalline
2DNs,
exhibit
subnanometer
uniformity,
ultrahigh
compressive
modulus
40
GPa,
low-bias
NDR
at
0.13
V
ultralow
power
consumption
down
to
0.05
nW/μm2.
This
highly
controlled
provides
a
unique
dimension
enhance
structural
diversity
2D
nanomaterials
for
high-density
low-power
electronics.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: June 6, 2024
Abstract
The
recent
success
of
gene
therapy
during
the
COVID‐19
pandemic
has
underscored
importance
effective
and
safe
delivery
systems.
Complementing
lipid‐based
systems,
polymers
present
a
promising
alternative
for
delivery.
Significant
advances
have
been
made
in
past,
with
multiple
clinical
trials
progressing
beyond
phase
I
several
companies
actively
working
on
polymeric
systems
which
provides
assurance
that
carriers
can
soon
achieve
translation.
massive
advantage
structural
tunability
vast
chemical
space
is
being
leveraged
to
mitigate
shortcomings
traditional
polycationic
improve
translatability
Tailored
approaches
diverse
nucleic
acids
specific
subcellular
targets
are
now
designed
therapeutic
efficacy.
This
review
describes
polymer
design
improved
by
polyplexes
covalent
polymer‐nucleic
acid
conjugates.
also
offers
brief
note
novel
computational
techniques
design.
concludes
an
overview
current
state
therapies
clinic
as
well
future
directions
their
translation
clinic.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(9), P. 4054 - 4077
Published: April 18, 2024
Stimuli-responsive
self-immolative
polymers
(SIPs)
represent
a
unique
class
of
that
can
undergo
controlled,
sequential
head-to-tail
depolymerization
upon
specific
stimuli.
Since
their
inception,
they
have
evolved
over
two
decades
to
become
one
the
most
attractive
polymer
types.
With
characteristic
feature
"one
stimulus,
multiple
responses",
SIPs
inherently
possess
ability
serve
as
chemical
amplifiers,
which
amplify
weak
or
biological
signals.
This
promises
higher
stimulus
sensitivity,
greater
selectivity
for
microenvironments,
and
potential
generate
more
persistent,
extensive,
significant
responses
while
consuming
fewer
stimuli
sources.
Review
summarizes
latest
research
advancements
in
stimuli-responsive
drug
delivery
molecular
imaging
past
five
years.
Regarding
structure
SIPs,
we
briefly
overview
updates
self-immolation
units,
end-cap
moieties,
sequence
SIPs.
In
terms
applications,
focus
on
possible
applications
disease
treatment
methods.
Finally,
provide
brief
perspective
future
directions
these
applications.
ACS Macro Letters,
Journal Year:
2024,
Volume and Issue:
13(1), P. 65 - 72
Published: Jan. 2, 2024
Sequence-defined
oligomers
(SDOs)
with
their
unique
monomeric
sequence
and
customizable
nature
are
attracting
the
attention
of
researchers
globally.
The
structural
functional
diversity
attainable
in
SDOs
makes
this
platform
promising,
albeit
challenges
synthesis.
Herein,
we
report
design
synthesis
a
novel
class
SDO
by
incorporating
tertiary
amines
into
backbone
from
commercially
available
inexpensive
materials.
Tertiary
were
selected
due
to
various
material
biomedical
applications.
Even
though
purification
amine
compounds
challenging,
significant
applications,
such
as
pharmaceuticals,
catalysts,
surfactants,
corrosion
inhibitors,
dye
intermediates,
polymer
additives,
rubber
accelerators,
gas
treating
agents,
agriculture,
analytical
chemistry,
make
them
fascinating.
synthetic
strategy
that
is
designed
here
extremely
efficient
economical
for
scalable
support-free,
protection–deprotection
chemistry-free,
catalyst/template-free.
Most
importantly,
no
extra
monomer
required
here.
key
reactions
employed
(i)
transformation
hydroxy
group
halide
(ii)
substitution
secondary
units.
Including
purifying
processes,
multigram
4-mer
was
completed
12–14
h.
established
synthesizing
two
different
sequences
SDOs.
characterized
1H
NMR
LC-MS.
tandem
MS
(MS/MS)
experiment
conducted
order
validate
over
chain.
Furthermore,
advanced
ways:
increasing
chain
length
via
attaching
linker,
which
provides
rapid
method
chain,
postsynthetic
modification
other
groups,
including
guanidine
biological
importance
well-known
fluorophore
dansyl
significance.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2701 - 2714
Published: April 12, 2024
Over
decades
of
development,
while
phosphoramidite
chemistry
has
been
known
as
the
leading
method
in
commercial
synthesis
oligonucleotides,
it
also
revolutionized
fabrication
sequence-defined
polymers
(SDPs),
offering
novel
functional
materials
polymer
science
and
clinical
medicine.
This
review
introduced
evolution
chemistry,
emphasizing
its
development
from
oligonucleotides
to
creation
universal
SDPs,
which
have
unlocked
potential
for
designing
programmable
smart
biomaterials
with
applications
diverse
areas
including
data
storage,
regenerative
medicine
drug
delivery.
The
key
methodologies,
functions,
biomedical
applications,
future
challenges
summarized
this
review,
underscoring
significance
breakthroughs
precisely
synthesized
materials.
ACS Macro Letters,
Journal Year:
2024,
Volume and Issue:
13(8), P. 979 - 986
Published: July 23, 2024
Digital
polymers
(DPs),
which
serve
as
promising
molecular-level
storage
media,
have
increasingly
garnered
interest.
Their
application
significantly
depends
on
the
efficiency
of
information
writing
(synthesis)
and
reading
processes
(sequencing).
For
reading,
rational
incorporation
weak
bonds
in
main
chain
was
applied
most
cases
order
to
improve
readability
tandem
mass
spectra
(MS/MS),
would
limit
length
DPs,
thus
reducing
capacity.
In
this
study,
introduction
commercially
available
crown
ether
(CE)
at
terminus
digital
oligo(γ-butyrolactone)s
(DOBLs)
enhances
predictability
fidelity
matrix-assisted
laser
desorption/ionization
time-of-flight
(MALDI-TOF
MS/MS),
improving
decoding
process.
The
use
ether,
leveraging
a
well-established
supramolecular
interaction
with
alkali
cations
known
since
1967,
offers
strong
affinity
between
ionization
agents
CE
motifs,
form
selective
effect
desired
fragments
during
MS.
This
method
is
particularly
effective
for
long-chain
extending
up
32-mer,
allows
customizable
fragmentation
patterns.
DP
end
presents
novel
efficient
strategy
enhancing
MS/MS
amplifying
capacity
polymers.
Polymer Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Precision
oligothiophenes
were
synthesized
from
terthiophene
in
an
efficient
manner.
Interestingly,
the
unreacted
was
readily
recovered
and
reused
subsequent
synthesis.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
The
selective
monoaddition
of
polymerizable
vinyl
monomers
like
styrenes
and
methacrylates
in
a
living
manner
has
been
achieved
for
the
flash-flow
preparation
molecules
defined
sequence
with
high
selectivity.
We
demonstrated
sequence-defined
synthesis
multifunctional
using
an
initiator,
functionalized
styrenes,
diarylethylenes,
various
methacrylates,
electrophilic
trapping
reagent
at
terminus
(six-component
sequential
connection
maximum)
without
any
intermediate
purification
steps.
anionic
flow
system
described
herein
is
active
polymerization,
such
that
styrene
or
methacrylate
can
be
expanded
to
afford
highly
dispersed
oligomers
affecting
other
single
units,
which
means
unequivocal
sequences
were
successfully
inserted
into
internal
terminal
positions.
methodology
provides
adaptable
method
construction
new
molecular
spaces
based
on
unimolecular
control
pinpoint
functionalization.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(22)
Published: Aug. 6, 2024
Abstract
Digitally‐encoded
poly(phosphodiesters)
(
d
‐PPDE)
with
highly
complex
primary
structures
are
evaluated
for
layer‐by‐layer
(LbL)
assembly.
To
be
easily
decoded
by
mass
spectrometry
(MS),
these
digital
polymers
contain
many
different
monomers:
2
coding
units
allowing
binary
encryption,
1
cleavable
spacer
controlled
MS
fragmentation,
and
3
tags
fragment
identification.
These
heteropolymers
therefore
composed
of
6
motifs.
Despite
this
strong
sequence
heterogeneity,
it
is
found
that
they
enable
a
LbL
film
formation.
For
instance,
regular
growth
observed
when
alternating
the
deposition
negatively‐charged
‐PPDE
positively‐charged
poly(allyl
amine
hydrochloride)
(PAH).
Yet,
in
approach,
interdistance
between
consecutive
coded
layers
remains
relatively
small,
which
may
an
issue
data
storage
applications,
especially
selective
decoding
stored
information.
Using
poly(sodium
4‐styrene
sulfonate)
(PSS)
as
intermediate
non‐coded
polyanion,
shown
can
achieved,
while
still
maintaining
growth.
Last
but
not
least,
work
small
molecular
weight
(i.e.,
significantly
smaller
than
those
PAH
PSS)
enables
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(36), P. 14938 - 14945
Published: Jan. 1, 2024
The
need
for
reliable
information
storage
is
on
a
steep
rise.
Sequence-defined
polymers,
particularly
oligonucleotides,
are
already
in
use
several
areas,
while
compound
mixtures
also
offer
simple
way
storing
information.
We
investigated
the
of
set
isotopologues
by
mixing,
where
stored
form
mass
spectrometric
(MS)
fingerprint
mixture.
A
small
molecule
with
24
non-labile
and
replaceable
hydrogen
atoms
was
selected
as
model,
components
covering
D
