The Role and Interactive Mechanism of Endoplasmic Reticulum Stress and Ferroptosis in Musculoskeletal Disorders DOI Creative Commons
Guohua Zhou, Ruimin Chi, Yawen Peng

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1369 - 1369

Published: Oct. 28, 2024

Endoplasmic reticulum (ER) stress is a cellular phenomenon that arises in response to the accumulation of misfolded proteins within ER. This process triggers activation signalling pathway known as unfolded protein (UPR), which aims restore ER homeostasis by reducing synthesis, increasing degradation, and promoting proper folding. However, excessive can perturb regular function contribute development diverse pathological conditions. As well known, ferroptosis kind programmed cell death characterized lipid peroxides iron-dependent reactive oxygen species (ROS), resulting oxidative harm structures. In recent years, there has been evidence indicating occurs musculoskeletal disorders (MSDs), with emerging recognition complex relationship between ferroptosis. review presents summary pathway. Most importantly, it delves into significance skeletal or muscle types. Furthermore, we highlight potential benefits targeting correlation treating degenerative MSDs.

Language: Английский

Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives DOI Creative Commons
Hao Chen, Zhongyu Han, Yi Wang

et al.

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 4661 - 4677

Published: Oct. 1, 2023

Abstract: Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. involved variety of physiological pathological processes. Since its discovery, has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress prospects, summarize regulatory mechanisms ferroptosis, discuss role pathogenesis diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), well therapeutic potential. Keywords: death, iron accumulation, peroxidation, diseases

Language: Английский

Citations

20
Cinnamaldehyde alleviates doxorubicin-induced cardiotoxicity by decreasing oxidative stress and ferroptosis in cardiomyocytes DOI Creative Commons
M. Mao, Zheng Wang, Bin Deng

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(10), P. e0292124 - e0292124

Published: Oct. 12, 2023

Although doxorubicin (DOX) is an efficient chemotherapeutic drug for human tumors, severe cardiotoxicity restricts its clinical use. Cinnamaldehyde (CA), a bioactive component isolated from Cinnamonum cassia, possesses potent anti-oxidative and anti-apoptotic potentials. The major aim of this study was to evaluate the protective role CA against DOX-induced cardiotoxicity. To end, cardiomyocyte injury models were developed using DOX-treated H9c2 cells rats, respectively. Herein, we found that treatment increased viability attenuated death in vitro. further protected rats cardiotoxicity, as indicated by elevated creatine kinase (CK) lactate dehydrogenase (LDH) levels, myocardium injury, myocardial fibrosis. alleviated oxidative stress regulating reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) levels. Mechanistically, markedly accelerated nuclear translocation erythroid factor 2-related 2 (Nrf2) heme oxygenase-1 (HO-1) expression. Consequently, decreased ferroptosis, while Erastin (a ferroptosis agonist) destroyed effect on increasing viability. Taken together, current results demonstrate alleviates providing promising opportunity increase application DOX.

Language: Английский

Citations

19
Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway DOI

Xuehui Deng,

Bingfeng Lin, Fang Wang

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 124, P. 155282 - 155282

Published: Dec. 14, 2023

Language: Английский

Citations

19
Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis DOI Creative Commons
Yunxia Du, Yantao Zhao, Yongxin Sun

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Sept. 14, 2023

Ferroptosis has been implicated in the pathological process of type 2 diabetic osteoporosis (T2DOP), although specific underlying mechanisms remain largely unknown. This study aimed to clarify role and possible mechanism acid sphingomyelinase (ASM)-mediated osteoblast ferroptosis T2DOP.We treated hFob1.19 cells with normal glucose (NG) different concentrations high (HG, 26.25 mM, 35 or 43.75 mM) for 48 h. We then measured cell viability osteogenic function, quantified autophagy levels, levels ASM ceramide cells. To further investigate mechanism, we examined these indicators by knocking down expression, hydroxychloroquine (HCQ) treatment, N-acetylcysteine (NAC) treatment. Moreover, a T2DOP rat model was induced microcomputed tomography used observe bone microstructure. also evaluated serum iron metabolism-associated factors, lipid peroxidation (LPO) expression ASM, LC3 GPX4 tissues.HG inhibited function osteoblasts inducing concentration-dependent manner. Furthermore, were increased HG factors required HG-induced reactive oxygen species (ROS) generation LPO. Similarly, inhibiting intracellular ROS reduced activation autophagy. ASM-mediated crucial degradation GPX4, improved decreasing autophagy, degradation, LPO subsequent ferroptosis. found that could alleviated model.ASM-mediated induces under conditions through providing novel mechanistic insight into treatment prevention T2DOP.

Language: Английский

Citations

17
Targeting STING: From antiviral immunity to treat osteoporosis DOI Creative Commons

Zhonghua Gao,

Zhongguo Gao,

Hao Zhang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 18, 2023

The cGAS-STING signaling pathway can trigger innate immune responses by detecting dsDNA from outside or within the host. In addition, has emerged as a critical mediator of inflammatory response and new target for diseases. STING activation leads to dimerization translocation endoplasmic reticulum Golgi intermediate compartment apparatus catalyzed TBK1, triggers production IRF3 NF-κB translocates nucleus induce subsequent interferon pro-inflammatory factor production. Osteoporosis is degenerative bone metabolic disease accompanied chronic sterile inflammation. Activating STING/IFN-β reduce resorption inhibiting osteoclast differentiation. Conversely, STING/NF-κB formation osteoporosis increasing decreasing formation. inhibits generation type H vessels with capacity osteogenesis, thereby Here, we outline mechanism action its downstream in discuss role targeting treatment osteoporosis, thus providing ideas osteoporosis.

Language: Английский

Citations

14
Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-κB signaling DOI Creative Commons

Chunchun Xue,

Huan Luo,

Libo Wang

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 13, 2023

Osteoporosis (OP), a prevalent public health concern primarily caused by osteoclast-induced bone resorption, requires potential therapeutic interventions. Natural compounds show as therapeutics for postmenopausal OP. Emerging evidence from in vitro osteoclastogenesis assay suggests that aconine (AC) serves an osteoclast differentiation regulator without causing cytotoxicity. However, the vivo functions of AC various OP models need clarification. To address this, we administered intraperitoneal injections to ovariectomy (OVX)-induced mice 8 weeks and found effectively reversed phenotype OVX mice, leading reduction vertebral loss restoration high turnover markers. Specifically, significantly suppressed decreasing expression osteoclast-specific genes such NFATc1 , c-Fos Cathepsin K Mmp9 . Importantly, can regulate ferroptosis suppressing Gpx4 upregulating Acsl4, which is achieved through inhibition phosphorylation I-κB p65 NF-κB signaling pathway. These findings suggest option managing signaling-mediated formation.

Language: Английский

Citations

14
Resveratrol-loaded nanoplatform RSV@DTPF promote alveolar bone regeneration in OVX rat through remodeling bone-immune microenvironment DOI Creative Commons
Haoran Peng, Xinyi Qiu, Mingyue Cheng

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146615 - 146615

Published: Oct. 18, 2023

The reconstruction of alveolar bone defect is essential for periodontal regenerative therapy or subsequent prosthetic/implant therapy, particularly in individuals with systemic diseases, such as osteoporosis. ROS accumulation, coupled aberrant macrophage polarization, pivotal the pathogenesis osteoporosis and contributes to disequilibrium between immune system. Consequently, therapeutic strategies targeting microenvironment present a promising approach treatment situ regeneration osteoporotic condition. Herein, we represented novel nano platform denoted RSV@DTPF, designed target facilitate controllable release resveratrol ROS-responsive behavior. This aims modulate tampered microenvironment. conjugated folate moiety selectively interacts receptors expressed on surface, thereby augmenting cellular uptake. while thioketal bond would break down when sensing high level intracellular encapsulated RSV. In vitro experiments suggested that designated nanoparticles could scavenge effectively restore M1/M2 ratio lipopolysaccharide(LPS)-stimulated inflammation environment; co-culture experiment provided evidence substantiating adeptness modified milieu fostering osteoblast differentiation, concurrently impeding osteoclast maturation. Furthermore, through comprehensive imaging histopathological evaluations, elucidate potential RSV@DTPF promoting osteogenesis within model utilizing ovariectomized (OVX) rats. vivo study substantiates advantageous impact nanoplatform its associated immunomodulatory effects. To sum up, exhibited capacity orchestrate microenvironmental shifts enhance generation ability also be expected applied other biomedical fields redox metabolism imbalance.

Language: Английский

Citations

13
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review DOI Creative Commons
Nemanja Živanović, Marija Lesjak, Nataša Simin

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 334 - 334

Published: March 10, 2024

Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.

Language: Английский

Citations

5
Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential DOI

Yanchen Feng,

Xue Dang,

Pan Zheng

et al.

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(3), P. 353 - 365

Published: April 23, 2024

Language: Английский

Citations

5
New insights into dairy management and the prevention and treatment of osteoporosis: The shift from single nutrient to dairy matrix effects—A review DOI
Kaili Wang,

Xu Zhao,

Sijia Yang

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(4)

Published: June 7, 2024

Abstract Dairy is recognized as a good source of calcium, which important for preventing osteoporosis. However, the relationship between milk and bone health more complex than just calcium supplementation. It unwise to focus solely on observing effects single nutrient. Lactose, proteins, vitamins in milk, well fatty acids, oligosaccharides, exosomes, all work together with enhance its bioavailability utilization efficiency through various mechanisms. We evaluate roles dairy nutrients active ingredients maintaining homeostasis from perspective matrix effects. Special attention given threshold effects, synergistic associations gut–bone axis. also summarize probiotic/prebiotic low‐fat/high‐fat lactose‐free fortified reduced risk osteoporosis discuss potential benefits controversies these products. Moreover, we examine role products increasing peak mass during adolescence reducing loss old age. provides theoretical reference use accurate prevention management related chronic diseases offers personalized dietary recommendations different populations.

Language: Английский

Citations

5