Journal of Pain, Journal Year: 2024, Volume and Issue: unknown, P. 104693 - 104693
Published: Oct. 1, 2024
Language: Английский
Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155480 - 155480
Published: Feb. 24, 2024
Language: Английский
Citations
8
Bone Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 23, 2025
Language: Английский
Citations
1
The Spine Journal, Journal Year: 2024, Volume and Issue: 24(6), P. 1034 - 1045
Published: Feb. 15, 2024
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 323 - 323
Published: March 2, 2025
Background: Pain is a major clinical and socioeconomic problem worldwide. The available therapies are not always effective often associated with the multiple adverse effects that reduce their application. Natural compounds an important group of pharmaceuticals may be used in pain management. We aimed to investigate analgesic activity sanguinarine–chelerythrine from Coptis chinensis. Methods: anti-inflammatory fraction C. chinensis extract (SC 5 10 mg/kg), sanguinarine (SAN 1 2 mg/kg) chelerythrine (CHEL 4 8 was assessed tail flick formalin tests. A microscopic macroscopic examination stomach mucosae performed. TNFα MMP-9 levels were measured ELISA kits. Results: Morphine (MORF), CHEL SC prolongated withdrawal latency, comparable between MORF mg/kg. MORF, mg/kg, SAN mg/kg ameliorated reaction neurogenic phase test. In inflammatory test, all tested substances exerted activity. SAN, additionally reduced secretion. Conclusions: Our results confirmed MORF. All investigated significant without concomitant gastrotoxicity.
Language: Английский
Citations
0
Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e19951 - e19951
Published: Sept. 1, 2023
Intervertebral disc degeneration (IDD) has been widely recognized as the primary cause of low back pain and is one major chronic diseases imposing a severe socioeconomic burden worldwide. IDD degenerative process characterized by inflammatory responses, its underlying pathological mechanisms remain complex. Genetic, developmental, biochemical, biomechanical factors contribute to development IDD. There pressing need for an effective non-surgical treatment, mainly due lack comprehensive understanding specific involved therapeutic targets Recently, interleukin (IL)-1β essential factor key mediator in Current studies have found that IL-1β affecting metabolism extracellular matrix regulating cell death (RCD), such apoptosis, pyroptosis, ferroptosis (a new form RCD). Although analysis clinical samples from different laboratories confirmed how induced IDD, signal transduction pathway, role mediated remains unclear. This review describes molecules IL-1β-mediated their roles resolving Understanding signaling pathways may lead class promote remission patients. aims provide framework treatment analyzing mechanism function related IL-1β, especially terms inflammation, metabolism, regulation.
Language: Английский
Citations
9
Frontiers in Rehabilitation Sciences, Journal Year: 2024, Volume and Issue: 5
Published: April 30, 2024
Background Matching disease and treatment mechanisms is a goal of the Precision Medicine Initiative. Pro- anti-inflammatory cytokines (e.g., Tumor Necrosis Factor-alpha, Transforming Growth Factor-beta, Interleukin-2, 10, 12) have gained significant amount interest in their potential role persistent pain for musculoskeletal (MSK) conditions. Manual therapy (MT) exercise are two guideline-recommended approaches treating MSK The objective this narrative overview was to investigate effects MT on pro- determine factors that lead variability results. Methods Two reviewers evaluated direction variabilities literature. A red, yellow, green light scoring system used define consistencies. Results Consistencies responses were seen with acute chronic both cytokines. Chronic associated consistent shift towards more cytokine profile (Transforming Interleukin-2 13, whereas bouts intense can transiently increase pro-inflammatory levels. influence less commonly studied yielded variable Conclusion Variability findings likely related subject baseline condition or disease, when measurement occurs, intensity, duration, an individual's overall health fitness.
Language: Английский
Citations
3
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 120, P. 106376 - 106376
Published: Aug. 5, 2024
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8566 - 8566
Published: May 10, 2023
Adiponectin, a hormone secreted by adipocytes, has anti-inflammatory effects and is involved in various physiological pathological processes such as obesity, inflammatory diseases, cartilage diseases. However, the function of adiponectin intervertebral disc (IVD) degeneration not well understood. This study aimed to elucidate AdipoRon, an agonist receptor, on human IVD nucleus pulposus (NP) cells, using three-dimensional vitro culturing system. also AdipoRon rat tail tissues vivo puncture-induced model. Analysis quantitative polymerase chain reaction demonstrated downregulation gene expression proinflammatory catabolic factors interleukin (IL)-1β (10 ng/mL) NP cells treated with (2 μM). Furthermore, western blotting showed AdipoRon-induced suppression p65 phosphorylation (p < 0.01) under IL-1β stimulation adenosine monophosphate-activated protein kinase (AMPK) pathway. Intradiscal administration was effective alleviating radiologic height loss induced annular puncture IVD, histomorphological degeneration, production extracellular matrix factors, cytokines. Therefore, could be new therapeutic candidate for early stage degeneration.
Language: Английский
Citations
8
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0280101 - e0280101
Published: Jan. 5, 2024
Senescence, particularly in the nucleus pulposus (NP) cells, has been implicated pathogenesis of disc degeneration, however, mechanism(s) annulus fibrosus (AF) cell senescence is still not well understood. Both TNFα and H2O2, have as contributors to pathways, their levels are increased degenerated discs when compared healthy discs. Thus, objective this study identify factor(s) that induces inner AF (iAF) senescence. Under exposure, at a concentration previously shown induce NP bovine iAF cells did undergo senescence, indicated by ability continue proliferate demonstrated Ki67 staining growth curves lack expression senescent markers, p16 p21. The response occurred even though express higher TNFR1 than cells. Interestingly, showed no increase intracellular ROS or secreted H2O2 which contrasted did. Following treatment, only had superoxide scavengers SOD1 SOD2 whereas NOX4 gene expression, an enzyme can generate H2O2. Treating with low dose (50 μM) induced however unlike TNFα, degenerative-like changes there was difference COL2, ACAN, MMP13, IL6 number COL2 ACAN immunopositive untreated controls. latter result suggests may distinct degenerative phenotypes. To evaluate paracrine signalling TNFα-treated were co-cultured. In contact co-culture secrete soluble factors within iAF. This contribute positive feedback loop degeneration. It possible these include cytokines (such TNFα). Further studies will investigate if human respond similarly.
Language: Английский
Citations
2
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: March 15, 2024
In this paper we synthesize an expansive body of literature examining the multifaceted influence chiropractic care on processes within and modulators neuroendocrine-immune (NEI) system, for purpose generating inductive hypothesis regarding potential impacts integrated physiology. Taking a broad, interdisciplinary, integrative view two decades research-documented outcomes care, inclusive reports ranging from systematic meta-analysis randomized observational trials to case cohort studies, review encapsulates rigorous analysis research suggests appropriateness more perspective impact systemic A novel salutogenic, health-promoting effects adjustment is presented, focused improvement physical indicators well-being adaptability such as blood pressure, heart rate variability, sleep, benefits that may be facilitated through multiple neurologically mediated pathways. Our findings support biological plausibility complex intervention not limited simple neuromusculoskeletal open new avenues future research, specifically exploration mapping precise neural pathways networks influenced by adjustment.
Language: Английский
Citations
2