NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(7), P. 2770 - 2795

Published: May 13, 2022

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival prognosis cancer patients. The epithelial-to-mesenchymal transition (EMT) well-known mechanism responsible for invasiveness cells. A number molecular pathways can regulate EMT in nuclear factor-kappaB (NF-κB) one them. translocation NF-κB p65 induce transcription several genes involved induction. present review describes interaction their association progression. Due to oncogenic role signaling, its activation enhances metastasis via This has been confirmed various cancers including brain, breast, lung gastric cancers, among others. ZEB1/2, transforming growth factor-β, Slug as inducers undergo upregulation by promote After induction driven NF-κB, significant decrease occurs E-cadherin levels, while N-cadherin vimentin levels an increase. noncoding RNAs potentially also function upstream mediators modulate NF-κB/EMT axis cancers. Moreover, mediating drug resistance Thus, suppressing sensitivity chemotherapeutic agents.

Language: Английский

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EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113774 - 113774

Published: Oct. 3, 2022

One of the malignant tumors in women that has involved both developed and developing countries is breast cancer. Similar to other types tumors, cancer cells demonstrate high metastatic nature. Besides, tumor have ability drug resistance. EMT related mechanism metastasis focus current manuscript highlighting function malignancy Breast increase their migration by induction During EMT, N-cadherin vimentin levels increase, E-cadherin decrease mediate EMT-induced invasion. Different kinds anti-cancer agents such as tamoxifen, cisplatin paclitaxel mediates chemoresistance feature cells. Furthermore, correlates with radio-resistance tumor. Clinical aspect reversing preventing chemotherapy or radiotherapy failure patients improving survival time. The anti-tumor suppress can be used for decreasing invasion increasing chemosensitivity lncRNAs, miRNAs factors modulate progression are discussed here.

Language: Английский

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Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action

Pharmacological Research, Journal Year: 2022, Volume and Issue: 186, P. 106505 - 106505

Published: Oct. 13, 2022

Language: Английский

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Multifunctional integrated electrochemical sensing platform based on mesoporous silica nanoparticles decorated single-wall carbon nanotubes network for sensitive determination of gallic acid

Ceramics International, Journal Year: 2023, Volume and Issue: 49(23), P. 37549 - 37560

Published: Sept. 9, 2023

Language: Английский

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Redox Homeostasis Disruptors Based on Metal‐Phenolic Network Nanoparticles for Chemo/Chemodynamic Synergistic Tumor Therapy through Activating Apoptosis and Cuproptosis

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(29)

Published: June 27, 2023

The combination of chemo/chemodynamic therapy is a promising strategy for improving antitumor efficacy. Herein, metal-phenolic network nanoparticles (NPs) self-assembled from copper ions and gallic acid (Cu-GA) are developed to evoke apoptosis cuproptosis synergistic therapy. Cu-GA NPs biodegraded in response the highly expressed glutathione (GSH) tumor cells, resulting simultaneous release Cu+ GA. intracellular GSH content dramatically reduced by released GA, rendering cells incapable scavenging reactive oxygen species (ROS) more susceptible cuproptosis. Meanwhile, ROS levels within significantly increased Fenton-like reaction , which disrupts redox homeostasis achieves apoptosis-related chemodynamic Moreover, massive accumulation further induces aggregation lipoylated dihydrolipoamide S-acetyltransferase downregulation iron-sulfur cluster protein, activating enhance efficacy NPs. experiments vivo demonstrate that exhibited excellent biosafety superior capacity, can efficiently inhibit growth tumors due activation specific hydrogen peroxide. These Cu-based provide potential build up efficient safe cancer

Language: Английский

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The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(5), P. 1919 - 1955

Published: Feb. 11, 2023

Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and mortality, any treatment targeting single session insufficient to tackle this. CHF characterized by reduced cardiac output resulting from neurohumoral dysregulation remodeling, which might be related oxidative stress, inflammation, endoplasmic reticulum apoptosis, autophagy, mitochondrial function, angiogenesis. These molecular mechanisms interact each other through crosstalk. Historically, Chinese medicinal herbs have been widely applied in the of CHF, therapeutic effects their ingredients scientifically confirmed over past decades. Traditional medicine (TCM) multiple components can confront different pathogenesis targets. This review analyzes commonly used TCM patent drugs decoctions that are applicable stages based on clinical trials. Diverse bioactive found treat via mechanisms. comprehensively covers key works underlying TCM, herbal synergistic constituent compatibility treating providing additional ideas address this threat.

Language: Английский

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The Potential Health Benefits of Gallic Acid: Therapeutic and Food Applications

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 1001 - 1001

Published: Aug. 18, 2024

Gallic acid (GA), a phenolic found in fruits and vegetables, has been consumed by humans for centuries. Its extensive health benefits, such as antimicrobial, antioxidant, anticancer, anti-inflammatory, antiviral properties, have well-documented. GA's potent antioxidant capabilities enable it to neutralize free radicals, reduce oxidative stress, protect cells from damage. Additionally, GA exerts anti-inflammatory effects inhibiting inflammatory cytokines enzymes, making potential therapeutic agent diseases. It also demonstrates anticancer properties cancer cell growth promoting apoptosis. Furthermore, offers cardiovascular lowering blood pressure, decreasing cholesterol, enhancing endothelial function, which may aid the prevention management of This review covers chemical structure, sources, identification quantification methods, biological GA, along with its applications food. As research progresses, future appears promising, uses functional foods, pharmaceuticals, nutraceuticals aimed at improving overall preventing disease. However, ongoing innovation are necessary fully understand address current challenges, establish mainstay nutritional interventions.

Language: Английский

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Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 13, 2022

Green chemistry has been a growing multidisciplinary field in recent years showing great promise biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and present insects fungi. This polysaccharide favorable characteristics, including biocompatibility, biodegradability, ease of modification by enzymes chemicals. CS-based nanoparticles (CS-NPs) have shown potential the treatment other diseases, affording targeted delivery overcoming drug resistance. The current review emphasizes on application CS-NPs chemotherapeutic agent, doxorubicin (DOX), therapy as they promote internalization DOX cells prevent activity P-glycoprotein (P-gp) to reverse These nanoarchitectures can provide co-delivery with antitumor agents such curcumin cisplatin induce synergistic Furthermore, co-loading siRNA, shRNA, miRNA suppress tumor progression chemosensitivity. Various nanostructures, lipid-, carbon-, polymeric- metal-based nanoparticles, are modifiable CS delivery, while functionalization ligands hyaluronic acid promotes selectivity toward prevents demonstrate high encapsulation efficiency due protonation amine groups CS, pH-sensitive release occur. redox- light-responsive prepared treatment. Leveraging these characteristics view biocompatibility CS-NPs, we expect soon see significant progress towards clinical translation.

Language: Английский

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In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation

Materials Today Bio, Journal Year: 2022, Volume and Issue: 15, P. 100278 - 100278

Published: May 10, 2022

The efficacy of neural repair and regeneration strategies for traumatic brain injury (TBI) treatment is greatly hampered by the harsh lesion microenvironment including oxidative stress hyper-inflammatory response. Functionalized hydrogel with capability suppression neuroinflammation inhibition will contribute to repairment TBI. Herein, antioxidant gallic acid-grafted hyaluronic acid (HGA) was combined acid-tyramine (HT) polymer develop an injectable dual-enzymatically crosslinking method. resulting HT/HGA biocompatible possesses effective scavenging activity against DPPH hydroxyl radicals. Meanwhile, this improved cell viability reduced intracellular reactive oxygen species (ROS) production under H2O2 insult. in vivo study showed that situ injection significantly malondialdehyde (MDA) increased glutathione (GSH) expression area after 3 or 21 days, which might be associated activation Nrf2/HO-1 pathway. Furthermore, promoted microglia polarization M2 (Arg1) phenotype, it also decreased level proinflammatory factors TNF-α IL-6 anti-inflammatory factor IL-4. Finally, blood-brain barrier (BBB) protected, neurogenesis hippocampus promoted, motor, learning memory ability enhanced. Therefore, injectable, biocompatible, exhibits a huge potential treating TBI allows us recognize great value novel biomaterial remodeling structure function.

Language: Английский

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Non-coding RNAs and macrophage interaction in tumor progression

Critical Reviews in Oncology/Hematology, Journal Year: 2022, Volume and Issue: 173, P. 103680 - 103680

Published: April 8, 2022

Language: Английский

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