Functional Food Chemical Ingredient Strategies for Non-alcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis: Chemical Properties, Health Benefits, Action, and Application

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(1), P. 1 - 14

Published: Jan. 3, 2024

Language: Английский

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The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 27, 2022

Background Rhubarb is an important traditional Chinese medicine, and rhein one of its most active ingredients. Studies have found that can improve ulcerative colitis by regulating gut microbes, but there are few reports on effects liver diseases. Therefore, this study aims to investigate these underlying mechanisms. Methods Mice were given (100 mg/kg), with both a normal control group model receiving the same amount saline for week. Acute injury was induced in mice intraperitoneal injection D-GalN (800 mg/kg)/LPS (10 ug/kg). Samples (blood, liver, stool) then collected assessed histological lesions used 16S rRNA gene sequencing, high-performance liquid chromatography-mass spectrometry (LC-MS) RNA-seq analysis. Results The levels ALT AST Model abnormal higher compared group, significantly relieved group. Hepatic HE staining showed degree lighter than microbiological results norank_o:Clostridia_UCG-014, Lachnoclostridium, Roseburia more abundant Notably, treatment reshaped disturbance intestinal microbial community D-GalN/LPS also had Verrucomicrobia, Akkermansiaceae Bacteroidetes. Additionally, There multiple metabolites different between such as L-α-amino acid, ofloxacin-N-oxide, 1-hydroxy-1,3-diphenylpropan-2-one,and L-4-hydroxyglutamate semialdehyde, returned after treatment. expression level changed significantly, various genes Cxcl2, S100a9, Tnf, Ereg, IL-10 up-regulated, while Mfsd2a Bhlhe41 down-regulated, which recovered Conclusion Overall, our show alleviated D-GalN/LPS-induced acute mice. It may help modulate microbiota mice, thereby changing metabolism intestine. Meanwhile, regulate alleviate injury.

Language: Английский

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Cordyceps guangdongensis lipid-lowering formula alleviates fat and lipid accumulation by modulating gut microbiota and short-chain fatty acids in high-fat diet mice

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 2, 2022

Obesity has caused serious health and economic problems in the world. Cordyceps guangdongensis is a high-value macrofungus with broad application potential food bio-medicine industry. This current study aimed to estimate role of C. lipid-lowering compound formula (CGLC) regulating fat lipid accumulation, gut microbiota balance, short-chain fatty acid (SCFA) contents, expression levels genes involved metabolism high-fat diet (HFD) mice. The results showed that CGLC intervention markedly reduced body weights accumulation HFD mice, improved glucose tolerance blood levels, decreased droplet vacuole liver. ratio Firmicutes Bacteroidetes increased relative abundances Bacteroides (B. acidifaciens) Bifidobacterium pseudolongum). In addition, treatment significantly promoted production SCFAs regulated Association analysis several species most were associated serum indicators. These suggested novel candidate formulation for treating obesity non-alcohol liver by microbiota, SCFAs, metabolism.

Language: Английский

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Effects of milling on texture and in vitro starch digestibility of oat rice

Food Chemistry X, Journal Year: 2023, Volume and Issue: 19, P. 100783 - 100783

Published: July 6, 2023

Compared with other oat products, consumers in China prefer rice and porridge made from naked oat. However, this product usually has poor sensory acceptance, which is directly related to the texture properties. This study aimed use milling method improve texture. The nutrient component, microstructure, pasting, thermal properties of treated different degrees (0 s, 20 40 60 80 s) were researched. results showed that would damage bran layer rice, increasing starch, β-glucan, total leached solids content, gelatinization enthalpy (ΔH). Meanwhile, oil, protein pasting viscosity, temperature decreased. Milling sticky soft, bound water non-flowing migrated like flowing water. cross-section damaged surface was beneficial entry starch dissolution, increased viscosity rice. When time s appearance, aroma, taste, texture, overall acceptability better. Moreover, rapid digestion fraction (k1) slow (k2) are lowest have effect low blood glucose rise rate.

Language: Английский

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Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 179, P. 113997 - 113997

Published: Aug. 19, 2023

Language: Английский

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