Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(5), P. 356 - 356
Published: May 16, 2024
Cordyceps sinensis is a precious medicinal and edible fungus, which widely used in body health care disease prevention. The current research focuses on the comparison of metabolite characteristics between small number samples lacks comprehensive evaluation quality C. large-scale space. In this study, LC-MS/MS, principal component analysis (PCA), hierarchical cluster (HCA), membership function method were to comprehensively evaluate metabolites 15 main producing areas China. results showed that total 130 categories, 14 supercategories, 1718 identified. Carboxylic acids derivatives, fatty acyls, organo-oxygen compounds, benzene substituted prenol lipids, glycerophospholipids components sinensis. HCA KEGG pathway enrichment 559 differentially accumulated (DAMs) accumulation models conjugates carbohydrates carbohydrate glycerophospholipid metabolism arginine proline may be one reasons for differences different areas. addition, 18 biomarkers identified validated, had significant discrimination effect (p < 0.05). Overall, YS, BR, ZD, with highest values, are rich balanced nutrients. They excellent raw materials development functional foods provide scientific guidance consumers nourish care.
Language: Английский
Citations
4Accumulation Characteristics of Natural Ophiocordyceps sinensis Metabolites Driven by Environmental Factors
Metabolites, Journal Year: 2024, Volume and Issue: 14(8), P. 414 - 414
Published: July 27, 2024
The environment is an important factor affecting the composition and abundance of metabolites in
Language: Английский
Citations
4Exploring global research status and trends in anti-obesity effects of traditional Chinese medicine through intestinal microbiota: a bibliometric study
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Nov. 16, 2023
Background The intestinal microbiota (IM) has been found to contribute metabolic disorders that lead excessive fat accumulation, systemic and chronic low-grade inflammation, insulin resistance in the host. Current research highlights a pivotal interaction between IM traditional Chinese medicine (TCM) mitigating obesity-related diseases. Undeniably, stands as central focus TCM aimed at preventing treating obesity. Therefore, tracing progress trends this field can offer valuable references insights for future studies. Methods On June 17, 2023, we conducted literature search on topic of “IM obesity TCM” spanning period from 2009 2023. We extracted primary information publications, which includes complete records reference citations, Science Citation Index Expanded (SCI-E) within Web Core Collection (WoSCC). To visualize analyze literature, utilized CiteSpace VOSviewer bibliometric analysis. Results During past fifteen years, rapid increase number publications observed. cooperative networks demonstrate China, Beijing University Medicine, Food & Function most active countries, organizations, journals field, respectively. Liu Bin contributed publications. A paper by Xu Jia, published 2014, holds highest Local Score (LCS). Analyses keyword co-occurrence co-citation indicate hotspots are primarily focused benefits driven endogenous functional molecules generated regulation IM. Other focal points include mechanism regulates restore mucosal barrier This is provisional file, not final typeset article, manages gut-organ axis, advantages acupuncture’s IM, process small transform Conclusion offers comprehensive understanding current status, hotspots, global research. Additionally, it provides summary exploration latest advancements thereby emphasizing essence more effectively.
Language: Английский
Citations
11Characterization of Metabolite Landscape Distinguishes Medicinal Fungus Cordyceps sinensis and other Cordyceps by UHPLC-Q Exactive HF-X Untargeted Metabolomics
Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7745 - 7745
Published: Nov. 24, 2023
Cordyceps represent a valuable class of medicinal fungi with potential utilization. The overexploitation and resource scarcity sinensis (CS) have led to the emergence such as militaris (CM) cicadae (CC) substitutes. value CS is often considered superior other Cordyceps, potentially owing differences in active ingredients. This study aimed evaluate composition abundance primary secondary metabolites its substitutes by untargeted metabolomics. A total 4671 from 18 superclasses were detected. rich amino acids, lipids, organic their derivatives. We statistically analyzed found 285 differential (3'-Adenylic acid, O-Adipoylcarnitine, L-Dopachrome, etc.) between CC, CM, CM which are biomarkers. L-glutamate glycerophospholipids metabolites. KEGG enrichment analysis indicated that tyrosine metabolic pathway tryptophan metabolism most differentially expressed pathways among three Cordyceps. In contrast, was enriched higher lipid when compared may be an indispensable foundation for pharmacological functions CS. conclusion, systematic, metabolomics analyses delivered precious insights into metabolite landscapes predicted components disease therapeutics.
Language: Английский
Citations
11Maternal Folic Acid Supplementation during Pregnancy Prevents Hepatic Steatosis in Male Offspring of Rat Dams Fed High-Fat Diet, Which Is Associated with the Regulation of Gut Microbiota
Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4726 - 4726
Published: Nov. 8, 2023
Maternal dietary patterns during pregnancy have been demonstrated to impact the structure of gut microbiota in offspring, altering their susceptibility diseases. This study is designed elucidate whether folic acid supplementation on hepatic steatosis male offspring rat dams exposed a high-fat diet (HFD) related gut-liver axis homeostasis. In this study, female rats were administered HFD and simultaneously supplemented with 5 mg/kg throughout pregnancy. Histopathological examination showed that effectively ameliorated lipid accumulation inflammatory infiltrate subjected maternal HFD. reduced abundance Desulfobacterota Firmicutes/Bacteroidota (F/B) ratio offspring. The expression tight junction proteins colon was significantly upregulated, serum LPS level reduced. Furthermore, there notable reduction TLR4/NF-κB signaling pathway subsequent mediators. Spearman's correlation analysis revealed significant associations between inflammation-related indices several microbiota, particularly Lactobacillus. With inflammation, PPAR-α SREBP-1c its downstream metabolism-related genes downregulated. summary, modulates enhances intestinal barrier integrity dams. helps reduce leakage suppress liver, thereby improving metabolism disorders, alleviating steatosis.
Language: Английский
Citations
10Characteristics of lipid accumulation induced by high-altitude environment improve the total antioxidant capacity of Ophiocordyceps sinensis
Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143812 - 143812
Published: March 1, 2025
Ophiocordyceps sinensis is a traditional Chinese herbal medicine and nutritional supplement, which rich in functional components beneficial to health. The biosynthesis of these affected by environment factors, especially lipids. This study analyzed the lipid mass spectrometry characteristics total antioxidant capacity (TAC) O. 5 different altitude environments explored important contributions environmental factors. pathway glycerophospholipid metabolism secondary metabolites was activated (AM) mean annual temperature (MAT) at high altitudes. stimulated degradation triglycerides (TG) phosphatidylcholine (PC), phosphatidylethanolamine (PE), promoted accumulation free radical scavenging (FRS) abilities (AC), increased its TAC. reflects role on formation bioactive provides scientific basis for exploring medicinal value value.
Language: Английский
Citations
0Effect of Artemisia selengensis Turcz extract on lipid metabolism and gut microbiota in high‐fat diet‐induced C57BL/6J obese mice
Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(4)
Published: April 1, 2025
Abstract Nowadays, obesity is a global health risk factor, and its development closely related to the absorption metabolism of lipids. In this study, main chemical constituents antiobesity effect Artemisia selengensis Turcz extract (ASTE) were investigated by HPLC‐QTOF‐MS 2 obese mice models. Twenty‐three compounds identified from ASTE, caffeoylquinic acid dicaffeoylquinic are dominant bioactive compounds. ASTE administration reduced body weight (9.8%), improved glucose tolerance (14.2%), corrected dyslipidemia (the levels total cholesterol, triglyceride, low‐density lipoprotein cholesterol dropped 19.8%, 24.4%, 27.2%, respectively, high‐density level rose 27.6%), alleviated hepatic lipid accumulation. gut microbiota dysbiosis caused High‐Fat Diet (HFD), mainly increasing relative abundance Odoribacter , Candidatus_Saccharimonas Bacteroides unclassified_f__Lachnospiraceae reducing Faecalibaculum . Gene expression heatmaps pathway enrichment analyses based on transcriptomics indicated that significantly HFD‐induced increases in fatty uptake, triglyceride synthesis, synthesis. Our findings holds significant potential as candidate for modulating preventing or treating obesity, meriting further investigation.
Language: Английский
Citations
0Gut microbiota and metabolite insights into anti-obesity effect of carboxymethyl pachymaran in high-fat diet mice
Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 111, P. 105898 - 105898
Published: Nov. 15, 2023
Poria cocos, a well-known traditional Chinese edible-medicinal mushroom, has shown many beneficial health effects. In this study, we investigated the anti-obesity and hyperlipidemia effect of carboxymethyl pachymaran (CMP) in high-fat diet mice, with focus on gut microbiota their metabolites. Results demonstrated that CMP notably decreased fat weights serum lipid, improved glucose tolerance, reduced lipid droplet level hepatic tissue. markedly ratio between Firmicutes Bacteroidetes, abundances Dubosiella newyorkensis Faecealibaculum rodentium, but increased Akkermansia muciniphila Bifidobacterium pseudolongum. addition, significantly promoted production butyric acid (BA) while levels bile acids. Association analysis showed physio-biochemical traits were negatively associated A. BA, whereas positive correlation to F. rodentium differential Together, can alleviate obesity related complications by modulating
Language: Английский
Citations
8An overview of traditional Chinese medicine affecting gut microbiota in obesity
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: March 1, 2023
Obesity, a chronic metabolic disease with complex pathophysiology, is caused by several variables. High-fat diets lead to the disruption of gut microbiota and impaired barrier function in obese people. The dysbiosis its metabolites through intestinal an imbalance energy metabolism inflammatory response, which eventually contributes development diseases such as diabetes, hypertension, cardiovascular disease. Current medicines are therapeutic obesity short term; however, they may bring significant physical emotional problems patients major side effects. Therefore, it urgent explore new methods that have definite efficacy, can be taken for long time, mild adverse Numerous studies demonstrated traditional Chinese medicine (TCM) control multi-targeted comprehensive manner, thereby restoring flora homeostasis, repairing damaged mucosal barriers, curbing obesity. active ingredients compounds TCM restore normal physiological regulating regulate metabolism, inhibit fat accumulation, affect food appetite, reduce effectively promoting weight loss providing strategies prevention treatment. Although there some on regulation prevent treat obesity, all them disadvantage being systematic comprehensive. this work comprehensively describes molecular mechanism mediated based research state microbiota, TCM. A summary targeting treatment should conducted order provide ideas
Language: Английский
Citations
7Effect and correlation of Cordyceps guangdongensis ethanolic extract on obesity, dyslipidemia and gut microbiota dysbiosis in high-fat diet mice
Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 107, P. 105663 - 105663
Published: July 12, 2023
Edible-medicinal fungi have shown many beneficial health effects. Cordyceps guangdongensis is a novel edible-medicinal fungus in China. In this study, we investigated the effects of ethanolic extract from C. fruiting bodies (CGE), and comprehensively dissected CGE on fat accumulation, dyslipidemia, gut microbial composition, short chain fatty acids (SCFAs). Results showed that markedly inhibited body weight gain, decreased accumulation various tissues, significantly improved glucose tolerance hyperlipidemia. notably restored high-fat diet induced shift Bacteroidetes to Firmicutes, increased abundances microbiota (such as Akkermansia muciniphila Bifidobacterium animalis). Interestingly, also promoted butyric acid (BA) production. Pairwise correlation analysis found A. muciniphila, B. animals BA were negatively associated with several fat-related parameters blood lipid indicators. Together, our results suggested represented potential supplement treat obesity related complications.
Language: Английский
Citations
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