Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings DOI Creative Commons
Wang Gu, Qiang Bao, Kaiqi Weng

et al.

Poultry Science, Journal Year: 2022, Volume and Issue: 102(2), P. 102382 - 102382

Published: Dec. 6, 2022

T-2 toxin is a dangerous natural pollutant and widely exists in animal feed, often causing toxic damage to poultry, such as slow growth development, immunosuppression, death. Although geese are considered the most sensitive poultry toxin, exact caused by elusive. In present study, total of forty two 1-day-old healthy Yangzhou male goslings were randomly allotted seven diets contaminated with 0, 0.2, 0.4, 0.6, 0.8, 1.0, or 2.0 mg/kg for 21 d, effects exposure on performance, feather quality, tibia blood parameters investigated. The results showed that significantly inhibited feed intake, body weight gain, shank length growth, organ development (e.g., ileum, cecum, liver, spleen, bursa, tibia) dose-dependent manner. addition, more serious feathering abnormalities observed exposed high dose (0.8, mg/kg), which mainly sparsely covered short, dry, rough, curly, gloss-free feathers back. We also found hypertrophic chondrocytes tibial plate exhibited abnormal morphology nuclear consolidation loss, accompanied necrosis excessive apoptosis under exposure. Moreover, triggered erythropenia, thrombocytosis, alanine aminotransferase, aspartate aminotransferase activity, well urea nitrogen, uric acid, lactic dehydrogenase levels. Collectively, these data indicate had an adverse effect liver kidney goslings, providing crucial information toward prevention control contamination feed.

Language: Английский

Pathological consequences, metabolism and toxic effects of trichothecene T-2 toxin in poultry DOI Creative Commons
Júlia Vörösházi, Zsuzsanna Neogrády, Gábor Mátis

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(3), P. 103471 - 103471

Published: Jan. 17, 2024

Contamination of feed with mycotoxins has become a severe issue worldwide. Among the most prevalent trichothecene mycotoxins, T-2 toxin is particular importance for livestock production, including poultry posing significant threat to animal health and productivity. This review article aims comprehensively analyze pathological consequences, metabolism, toxic effects in poultry. Trichothecene primarily produced by Fusarium species, are notorious their potent toxicity. exhibits broad spectrum negative on leading substantial economic losses as well concerns about welfare food safety modern agriculture. exposure easily results consequences gastrointestinal tract, parenchymal tissues like liver (as key organ its metabolism), kidneys, or reproductive organs. In addition, it also intensely damages immune system-related such spleen, bursa Fabricius, thymus causing immunosuppression increasing susceptibility animals infectious diseases, making immunization programs less effective. The cellular processes transcriptional translational levels induces apoptosis through activation numerous signaling cascades. Furthermore, according recent studies, besides direct abovementioned processes, production reactive molecules free radicals resulting oxidative distress concomitantly occurring damage. conclusion, this provides complex detailed overview mechanism action immunomodulatory stress-related toxin. Understanding these crucial developing strategies mitigate impact avian future.

Language: Английский

Citations

16
T-2 toxin-induced testicular impairment by triggering oxidative stress and ferroptosis DOI Creative Commons
Jun He, Jin Hong, Jiabin Guo

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 270, P. 115844 - 115844

Published: Dec. 21, 2023

T-2 toxin is a trichothecene mycotoxin of significant danger to humans and animals. Its impact on reproductive toxicity attributed oxidative stress, which ultimately leads cell death. Ferroptosis programmed death that characterized by lipid peroxidation. This study aimed investigate the toxic effects mouse testis potential mechanism toxin-induced ferroptosis. significantly altered morphology decreased testosterone level, sperm concentration, increased malformation rate, as well induced damage with reactive oxygen species malondialdehyde accumulated, activity superoxide dismutase, glutathione peroxidase decreased. Additionally, ferroptosis accumulating iron ions, increasing prostaglandin endoperoxide synthase 2, downregulating 4 ferritin heavy chain 1, manifesting ferroptotic morphological alterations, leading testicular impairment. Administration inhibitor liproxstatin-1 or antioxidant resveratrol effectively mitigated injury. These findings provided novel insights into fundamental furnished further proof therapeutic effect in addressing

Language: Английский

Citations

12
The Co-Occurrence of T-2 Toxin, Deoxynivalenol, and Fumonisin B1 Activated the Glutathione Redox System in the EU-Limiting Doses in Laying Hens DOI Creative Commons
Szabina Kulcsár, Benjámin Kövesi, Krisztián Balogh

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(5), P. 305 - 305

Published: April 23, 2023

Different mycotoxins in feed lead to combined exposure, increasing adverse effects on animal health. Trichothecene have been associated with inducing oxidative stress, which is neutralized by the glutathione system within antioxidant defense, depending dose and duration of exposure. T-2 toxin, deoxynivalenol (DON), fumonisin B1 (FB1) are commonly found commodities simultaneously. In present study, intracellular biochemical gene expression changes were investigated case multi-mycotoxin focusing certain elements redox system. a short-term feeding trial, an vivo study was performed low (EU-proposed) doses: T-2/HT-2 toxin: 0.25 mg; DON/2-AcDON/15-AcDON.: 5 FB1: 20 mg/kg feed, high doses (twice dose) laying hens. The exposure affected system; GSH concentration GPx activity higher liver low-dose group day 1 compared control. Furthermore, enzymes increased significantly both levels results suggest that when EU-limiting applied, individual may synergistic effect induction stress.

Language: Английский

Citations

11
A Comprehensive Review of Mycotoxins, Their Toxicity, and Innovative Detoxification Methods DOI Creative Commons
Ravikant Shekhar, Vinay B. Raghavendra,

P. Rachitha

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101952 - 101952

Published: Feb. 7, 2025

A comprehensive overview of food mycotoxins, their toxicity, and contemporary detoxification techniques is given in this article. Mycotoxins, which are harmful secondary metabolites generated by a variety fungi, including Fusarium, Aspergillus, Penicillium, provide serious health concerns to humans animals. These include hepatotoxicity, neurotoxicity, carcinogenicity. Mycotoxins commonly found basic products, as evidenced recent studies, raising worries about public safety. The article discusses detection such enzyme-linked immunosorbent assays (ELISA), quick strip tests. Moreover, the use various control systems associated with mycotoxinis highlighted. In addition, novel strategies nanotechnology, plant extracts, omics studies were also discussed. When taken whole, analysis helps clarify pressing need for efficient management monitoring prevent mycotoxin contamination chain.

Language: Английский

Citations

0
T-2 toxin-induced splenic injury by disrupting the gut microbiota–spleen axis via promoting IL-6/JAK/STAT1 signaling-mediated inflammation and apoptosis and its mitigation by elemental nano-selenium DOI
Meng Liu, Xuewu Li, Hua Sun

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
Recognition mechanism of split T-2 toxin aptamer coupled with reliable dual-mode detection in peanut and beer DOI
Ping Zhu, Precious Asumadu, S Y Zhou

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104268 - 104268

Published: May 10, 2024

Language: Английский

Citations

3
Exposure to a Combination of Fusarium Mycotoxins Leads to Lipid Peroxidation and Influences Antioxidant Defenses, Fatty Acid Composition of Phospholipids, and Renal Histology in Laying Hens DOI Creative Commons
Szabina Kulcsár,

Janka Turbók,

György Kövér

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(5), P. 226 - 226

Published: May 13, 2024

The effects of combined short-term (3 days) exposure to Fusarium mycotoxins at both the EU recommended limit (T-2/HT-2 toxin: 0.25 mg/kg; DON/3-AcDON/15-AcDON: 5 FB1: 20 mg/kg) and twice dose 0.5 mg/kg, 10 40 mg/kg feed) on kidneys laying hens were examined. Our study aimed investigate how these interacted with membrane lipid fatty acid (FA) composition peroxidation processes. It was observed that levels conjugated dienes trienes higher than control in low-mix group day 3, malondialdehyde concentration days 2 3. proportion phospholipid (PL) FAs showed saturated monounsaturated increased. Still, n3 n6 polyunsaturated decreased significantly high-mix group. Among FAs, level docosahexaenoic (C22:6 n3) among arachidonic (C20:4 n6) acids mainly results suggest induced hens, which resulted marked changes PL FA profile. Histological examination revealed time- dose-dependent increases as consequences mycotoxin exposure.

Language: Английский

Citations

3
p38 mediates T-2 toxin-induced Leydig cell testosterone synthesis disorder DOI Creative Commons
Xu Yang,

Wenxi Song,

Kefei Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 253, P. 114695 - 114695

Published: Feb. 27, 2023

T-2 toxin is an unavoidable food and feed contaminant that seriously threatens human animal health. Exposure to can cause testosterone synthesis disorder in male animals, but the molecular mechanism still not completely clear. The MAPK pathway participates regulation of by Leydig cells, it unclear whether toxin-induced disorders. In this research, capacity, synthase expression activation were examined mice TM3 cells exposed toxin. results showed exposure decreased testicular volume caused pathological changes microstructure ultrastructure cells. also content protein synthase. vitro, inhibited cell viability contents culture supernatants. Moreover, activated increasing p38, JNK ERK as well p-p38, p-JNK p-ERK testis p38 inhibitor (SB203580) significantly alleviated decrease reduction summary, mediates disorder.

Language: Английский

Citations

8
Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ERα/PI3K/Akt signaling pathway DOI Creative Commons
Haobiao Liu, Xue Lin, Mumba Mulutula Chilufya

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 269, P. 115748 - 115748

Published: Nov. 28, 2023

As common pathogenic agents in the world and widely distributed globally, T-2 toxin selenium deficiency might exacerbate toxic effects by combined exposure, posing a dramatic health hazard to humans animals. In this study, we aim elucidate underlying mechanisms of renal fibrosis triggered exposure. A total thirty-two rats are randomly divided into normal control, toxin, deficiency, intervention groups. (100 ng/g) is intragastric gavaged compliance with body weight. Both standard (containing 0.20 mg/Kg) selenium-deficient 0.02 diets were manufactured adhering AIN-93 formula. After 12 weeks intervention, tissue ultrastructural pathological changes, inflammatory infiltration, epithelial mesenchymal transition (EMT), extracellular matrix (ECM) deposition evaluated, respectively. Metabolomics analysis conducted explore pathology fibrosis, followed validation potential at gene protein levels. exposure results podocyte foot process elongation or fusion, tubular vacuolization dilatation, collagen kidneys. Additionally, it also increases EMT conversion, ECM deposition. suggests that influence amino acid cholesterol metabolism, respectively, estrogen signaling pathway probably engaged progression. Moreover, found regulate expressions ERα/PI3K/Akt pathway. conclusion, synergistically through regulating pathway, involved process.

Language: Английский

Citations

8
Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review DOI Creative Commons
Pengju Wang, Lv‐Hui Sun,

Xu Wang

et al.

Animal nutrition, Journal Year: 2023, Volume and Issue: 16, P. 251 - 266

Published: Dec. 4, 2023

T-2 toxin is one of the most widespread and toxic fungal toxins in food feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive neurotoxicity, nephrotoxicity humans animals. physicochemically stable does not readily degrade during feed processing. Therefore, suppressing toxin-induced organ toxicity through antidotes an urgent issue. Protective agents against have been recorded widely literature, but these protective their molecular mechanisms detoxification comprehensively summarized. In this review, we provide overview various to underlying effects. Targeting appropriate targets antagonize also important option. This review will essential guidance strategies for better application development specific future.

Language: Английский

Citations

8