Circulating Microrna-146a as A Biomarker Related To Inflammation in Thalasemia Patients DOI Creative Commons

Heba Hani Hamzah,

Nawal Khinteel Jabbar

Academia Open, Journal Year: 2023, Volume and Issue: 9(2)

Published: Oct. 11, 2023

This study delves into the intricate realm of microRNAs (miRNAs), non-coding RNA molecules that wield significant influence in pathogenesis various disorders. With advent advanced technologies, accurate quantification miRNA abundance across diverse tissues is now attainable. Notably, extracellular circulating microparticles have emerged as robust, stable indicators for blood-based disease diagnostics. investigation explores dynamic interplay between and clinical phenotypes, offering valuable insights intricacies. The research narrows its focus to recent developments employing biomarkers prevalent inflammatory disorders, including infections endemic thalassemia patients city Diwaniyah, Iraq. Current findings paint a promising future utilization management diseases. In conclusion, this comprehensive exploration miRNA's regulatory role globin gene expression has potential revolutionize landscape thalassemia, ameliorating manifestations symptoms debilitating hemoglobinopathy. identification miRNAs implicated disease's pathophysiology not only paves way novel diagnostic markers but also opens new horizons therapeutic interventions. Highlights : MiRNA Significance: MicroRNAs play pivotal mechanisms. Circulating Microparticles: Extracellular are indicators, holding promise diagnostics management, especially context Thalassemia Insights: highlights impact on expression, avenues diagnosis treatment Keywords Microparticles, Thalassemia, Inflammatory Disorders, Disease Diagnostics

Language: Английский

Individual blood concentrations of persistent organic pollutants and chemical elements, and COVID-19: A prospective cohort study in Barcelona DOI Creative Commons
Miquel Porta, José Pumarega, Magda Gasull

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 223, P. 115419 - 115419

Published: Feb. 4, 2023

There is wide, largely unexplained heterogeneity in immunological and clinical responses to SARS-CoV-2 infection. Numerous environmental chemicals, such as persistent organic pollutants (POPs) chemical elements (including some metals, essential trace elements, rare earth minority elements), are immunomodulatory cause a range of adverse events. no prospective studies on the effects substances incidence infection COVID-19.To investigate influence blood concentrations POPs measured several years before pandemic development COVID-19 individuals from general population.We conducted cohort study 154 population Barcelona. were samples collected 2016-2017. was detected by rRT-PCR nasopharyngeal swabs and/or antibody serology using eighteen isotype-antigen combinations 2020-2021. We analyzed associations between contaminants COVID-19, taking into account personal habits living conditions during pandemic.Several historically prevalent POPs, well arsenic, cadmium, mercury, zinc, not associated with nor However, DDE (adjusted OR = 5.0 [95% CI: 1.2-21]), lead (3.9 [1.0-15]), thallium (3.4 [1.0-11]), ruthenium (5.0 [1.8-14]) tantalum, benzo(b)fluoranthene, DDD, manganese. Thallium (3.8 [1.6-8.9]), (2.9 [1.3-6.7]) infection, so lead, gold, (protectively) iron selenium. identified mixtures up five groups, all independently outcomes.Our results provide first population-based evidence an association individual may contribute explain population. If confirmed causal, means available mitigate corresponding risks.

Language: Английский

Citations

12
Evaluation of various blood biomarkers associated with the outcomes of patients with COVID‑19 treated in intensive care units DOI Open Access
Sıdıka Genç, Ali Taghizadehghalehjoughi, Muhammet Emin Naldan

et al.

Experimental and Therapeutic Medicine, Journal Year: 2024, Volume and Issue: 27(2)

Published: Jan. 4, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection and the resulting disease 2019 (COVID‑19) represented a global public health crisis most significant pandemic in modern times. Transmission characteristics, lack of effective antiviral treatment protocol protective vaccines, pushed healthcare systems, particularly intensive care units (ICUs), to their limits led extreme quarantine measures control pandemic. It was evident from an early stage that patient stratification approaches needed be developed better predict progression. In present study, predictive value clinical blood biomarkers for outcomes patients with COVID‑19 hospitalized ICU were investigated, taking age sex into consideration. The study analyzed samples 3,050 ICU. analysis revealed levels procalcitonin, N‑terminal pro‑B‑type natriuretic peptide, D‑dimer, ferritin, liver enzymes, C‑reactive protein lactate dehydrogenase increased associated progression, prolonged hospitalization period severe related complications. Additionally, disparities among these documented discussed specific cases. On whole, results suggest potential association demographic characteristics mortality COVID‑19.

Language: Английский

Citations

4
Predictive Ability of Previous Pain and Disease Conditions on the Presentation of Post‐COVID Pain in a Danish Cohort of Adult COVID‐19 Survivors DOI Creative Commons
Brian Duborg Ebbesen, Jakob Nebeling Hedegaard, Simon Grøntved

et al.

European Journal of Pain, Journal Year: 2025, Volume and Issue: 29(5)

Published: April 5, 2025

ABSTRACT Background Even though many post‐COVID pain risk factors have been identified, little is known about the predictive profiles of these for development pain. Methods Data was collected from two separate questionnaires assessing demographics, pre‐existing medical comorbidities, history, and experience. Socioeconomic data COVID‐19 RT‐PCR test results were Danish registries. The study cohort ( n = 68,028) stratified into groups reporting pre‐COVID 9090) no 55,938). Forward‐selection prediction models employed to identify predictor in full (Model 1) with 2) without 3) 58 potential factors. Results Model 1 achieved a 5‐fold cross‐validated AUC (cvAUC) 0.68. Use medication, stress, high income, age, female gender, weight top predictors contributing 97% model performance. 2 (cvAUC 0.69) identified use breathing pain, height, physical activity, as 98.6% 3 0.65) weight, higher education, activity 98.5% Height unique 2, while being income 3. Conclusions highlights important predictors, further research needed describe detail. may apply understanding post‐viral sequelae after other viral infections. Significance Statement explorative investigates ability battery potentially associated This article presents interest survivors will contribute patient that might develop conditions provide first step towards focused clinical research.

Language: Английский

Citations

0
Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection DOI
José Pumarega, Magda Gasull, Jani Koponen

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116965 - 116965

Published: Aug. 29, 2023

Language: Английский

Citations

4
COVID-19-Osteoarthritis Interactions, Predictions, and Mitigation: Can Blue Zone Findings Help? Overview and Commentary DOI Open Access
Ray Marks

Acta Scientific Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: unknown, P. 26 - 36

Published: Nov. 1, 2023

The corona virus-19 , which unexpectedly heightened multiple health challenges among older adults beginning in December 2019, continues to influence many facets of elder including having a possible role exacerbating osteoarthritis linkages or combination 2023 and possibly beyond this period.At the same time, recent 2050 prevalence predictions that may well be underestimates imply any effort minimize disability must highly warranted its own right, because is major risk factor for severe COVID-19 infections.Based on key 2022-2023 data base posting, small body current work strengthens case our view more elucidation interpretation clinical significance presently alluded not overlook what has been learned about population wellbeing healthy aging from both pandemic as successes Blue Zone locations.

Language: Английский

Citations

1
Circulating Microrna-146a as A Biomarker Related To Inflammation in Thalasemia Patients DOI Creative Commons

Heba Hani Hamzah,

Nawal Khinteel Jabbar

Academia Open, Journal Year: 2023, Volume and Issue: 9(2)

Published: Oct. 11, 2023

This study delves into the intricate realm of microRNAs (miRNAs), non-coding RNA molecules that wield significant influence in pathogenesis various disorders. With advent advanced technologies, accurate quantification miRNA abundance across diverse tissues is now attainable. Notably, extracellular circulating microparticles have emerged as robust, stable indicators for blood-based disease diagnostics. investigation explores dynamic interplay between and clinical phenotypes, offering valuable insights intricacies. The research narrows its focus to recent developments employing biomarkers prevalent inflammatory disorders, including infections endemic thalassemia patients city Diwaniyah, Iraq. Current findings paint a promising future utilization management diseases. In conclusion, this comprehensive exploration miRNA's regulatory role globin gene expression has potential revolutionize landscape thalassemia, ameliorating manifestations symptoms debilitating hemoglobinopathy. identification miRNAs implicated disease's pathophysiology not only paves way novel diagnostic markers but also opens new horizons therapeutic interventions. Highlights : MiRNA Significance: MicroRNAs play pivotal mechanisms. Circulating Microparticles: Extracellular are indicators, holding promise diagnostics management, especially context Thalassemia Insights: highlights impact on expression, avenues diagnosis treatment Keywords Microparticles, Thalassemia, Inflammatory Disorders, Disease Diagnostics

Language: Английский

Citations

0