Bee Pollen as a Source of Biopharmaceuticals for Neurodegeneration and Cancer Research: A Scoping Review and Translational Prospects DOI Creative Commons

Rachid Kacemi,

María G. Campos

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5893 - 5893

Published: Dec. 13, 2024

Bee Pollen (BP) has many advantageous properties relying on its multitargeting potential, a new tendency in managing challenging illnesses. In cancer and neurodegeneration, the multiple effects of BP could be unequaled importance need further investigation. Although still limited, available data interestingly spotlights some floral sources with promising activities line this Adopting scoping review methodology, we have identified crucial bioactivities that are widely recognized to individual compounds but remain completely untapped valuable bee cocktail. A wide range these been recently found endowed great potential modulating pivotal processes neurodegeneration pathophysiology. addition, ubiquitous only isolated, while number studied BPs remains extremely limited compared endless pool plant species worldwide. We also elucidated clinical profits from perspectives impeded by hurdles such as bioavailability phytocompounds, diversity lack phytochemical standardization BP, difficulty selective targeting pathophysiological mechanisms. finally present interesting insights guide future research pave way for urgently needed simplified investigations.

Language: Английский

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World DOI Open Access

Rachid Kacemi,

María G. Campos

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2413 - 2413

Published: May 22, 2023

The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved the genesis development of many world-scale public health burdens, such as metabolic cardiovascular diseases. In recent years, bee pollen emerging scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix being extensively studied, has proven very rich well-balanced nutrient pool. this work, we reviewed available evidence interest source. We mainly focused richness nutrients its possible roles main pathophysiological processes that are directly linked imbalances. scoping review analyzed scientific works published last four focusing clearest inferences perspectives translate cumulated experimental preclinical into clinically relevant insights. promising uses for malnutrition, digestive health, disorders, other bioactivities could helpful readjust homeostasis (as it also true case anti-inflammatory or anti-oxidant needs), well benefits diseases, were identified. knowledge gaps identified, along with practical challenges hinder establishment fructification these uses. A complete data collection made major range botanical species allows more robust clinical information.

Language: Английский

Citations

15

Revolutionizing the Use of Honeybee Products in Healthcare: A Focused Review on Using Bee Pollen as a Potential Adjunct Material for Biomaterial Functionalization DOI Creative Commons
Arka Sanyal, Anushikha Ghosh, Chandrashish Roy

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(7), P. 352 - 352

Published: July 4, 2023

The field of biomedical engineering highly demands technological improvements to allow the successful engraftment biomaterials requested for healing damaged host tissues, tissue regeneration, and drug delivery. Polymeric materials, particularly natural polymers, are one primary suitable materials employed functionalized enhance their biocompatibility thus confer advantageous features after graft implantation. Incorporating bioactive substances from nature is a good technique expanding or increasing functionality biomaterial scaffolds, which may additionally encourage healing. Our ecosystem provides resources, like honeybee products, comprising rich blend phytochemicals with interesting properties, which, when functionally coupled biomaterials, result in exhibiting anti-inflammatory, antimicrobial, antioxidant effects. Bee pollen sustainable product recently discovered as new functionalizing agent biomaterials. This review aims articulate general idea using products engineering, mainly focusing on describing recent literature experimental studies bee pollen. We have also described underlying mechanism attributes shared our perspective how future research will benefit fabrication such

Language: Английский

Citations

13

Exploring the therapeutic applications of nano-therapy of encapsulated cisplatin and anthocyanin-loaded multiwalled carbon nanotubes coated with chitosan-conjugated folic acid in targeting breast and liver cancers DOI

Mai G. Awad,

Nemany A.N. Hanafy, Ramadan A. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135854 - 135854

Published: Sept. 1, 2024

Language: Английский

Citations

5

Synthesis of 1,3-benzodioxole-based procaine-tagged ionic liquids and investigation of its physiochemical and anti-cancer properties against A549 cells DOI

Sangeeta Yadav,

Sonaxi,

Neetu Kumari

et al.

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 391, P. 123325 - 123325

Published: Oct. 12, 2023

Language: Английский

Citations

12

Development of honey bee pollen doped CeO2 for electrochemical sensor detection of uric acid and dopamine DOI

M. Mylarappa,

C. Selvam,

G. Krishnamurthy

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113039 - 113039

Published: Feb. 1, 2025

Language: Английский

Citations

0

Bee pollen as a food and feed supplement and a therapeutic remedy: recent trends in nanotechnology DOI Creative Commons
Syed Ishtiaq Anjum, Amjad Ullah,

Faryal Gohar

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 4, 2024

Pollen grains are the male reproductive part of flowering plants. It is collected by forager honey bees and mixed with their salivary secretions, enzymes, nectar, which form fermented pollen or “bee bread” stored in cells wax honeycombs. Bee (BP) a valuable apitherapeutic product considered nutritional healthy food appreciated natural medicine from ancient times. Recently, BP has been beneficial supplement value-added that contains approximately 250 different bioactive components. numerous elements such as Mg, Ca, Mn, K, phenolic compounds. possesses strong antioxidant, anti-inflammatory, antimicrobial, antiviral, analgesic, immunostimulant, neuroprotective, anti-cancer, hepatoprotective properties. used for purposes welfare mankind. Additionally, there growing interest bee products harvesting utilizing many remedy nutritive function. In this review, impacts on organisms ways highlighting its efficacy described.

Language: Английский

Citations

3

Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications DOI Creative Commons

Shaden A. M. Khalifa,

Aya A. Shetaia,

Nehal Eid

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(8), P. 829 - 829

Published: Aug. 14, 2024

Bee products, abundant in bioactive ingredients, have been utilized both traditional and contemporary medicine. Their antioxidant, antimicrobial, anti-inflammatory properties make them valuable for food, preservation, cosmetics applications. Honeybees are a vast reservoir of potentially beneficial products such as honey, bee pollen, bread, beeswax, venom, royal jelly. These rich metabolites vital to human health, including proteins, amino acids, peptides, enzymes, sugars, vitamins, polyphenols, flavonoids, minerals. The advancement nanotechnology has led continuous search new natural sources that can facilitate the easy, low-cost, eco-friendly synthesis nanomaterials. Nanoparticles (NPs) actively synthesized using honeybee which serve dual purposes preventive interceptive treatment strategies due their richness essential metabolites. This review aims highlight potential role this line applications catalysts food preservatives point out anticancer, antibacterial, antifungal, antioxidant underlying impacts. research used several online databases, namely Google Scholar, Science Direct, Sci Finder. overall findings suggest these bee-derived substances exhibit remarkable properties, making promising candidates economical production NPs.

Language: Английский

Citations

3

Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases DOI
Ayeh Bani Saeid, Vyoma K. Patel,

Samir Mehndiratta

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 56, P. 103205 - 103205

Published: Sept. 26, 2023

Language: Английский

Citations

8

Antimicrobial and Antiproliferative Activity of Green Synthesized Silver Nanoparticles Using Bee Bread Extracts DOI Creative Commons
Adriana Cristina Urcan, Adriana Criste,

Karina Ioana Szanto

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1797 - 1797

Published: June 23, 2023

Bee bread (BB) is a fermented mixture of bee pollen, rich in proteins, amino acids, fatty polyphenols, flavonoids, as well other bioactive compounds, and considered functional food for humans. In this study, we explored an innovative green synthesis colloidal silver nanoparticles, using BB extracts reducing stabilizing agents. A preliminary chemical characterization the was conducted. The plasmonic response as-synthesized nanoparticles (BB-AgNPs) evaluated by UV-Vis spectroscopy, while their hydrodynamic diameter zeta potential were investigated dynamic light spectroscopy (DLS). Transmission electron microscopy (TEM) analysis pointed out polydisperse NPs with quasi-spherical shapes. newly synthesized showed good antioxidant activity against tested free radicals, DPPH, ABTS•+, FRAP, best results being obtained case ABTS•+. BB-AgNPs exhibited antibacterial on Gram-positive Gram-negative bacterial strains: herein S. aureus, B. cereus, E. faecalis, coli, P. aeruginosa, enteritidis, yeast C. albicans, respectively. inhibition diameters varied between 7.67 ± 0.59 22.21 1.06 mm, values minimum inhibitory concentration 0.39 6.25 µg/mL. vitro antiproliferative colon adenocarcinoma, ATCC HTB-37 cell line, have shown that synthetized induced substantial decrease tumor viability dose-dependent manner IC50 ranging from 24.58 to 67.91 Consequently, more investigation required comprehend processes cytotoxicity AgNPs develop strategies mitigate potentially harmful effects harnessing antimicrobial properties.

Language: Английский

Citations

7

Environmentally Friendly Synthesis of 2D Cu2O Nanoleaves: Morphological Evaluation, Their Photocatalytic Activity Against Azo Dye And Antibacterial Activity For Ceramic Structures DOI
Fatma Göl, Ayşenur Aygün, Cigdem Ture

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(5), P. 5458 - 5467

Published: May 20, 2024

Language: Английский

Citations

2