Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model DOI Creative Commons
Fei Tong,

Pei Wang,

Ziqiang Chen

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 2371 - 2388

Published: May 1, 2023

Introduction: The critical challenge for periodontitis therapy is thoroughly eliminating the dental plaque biofilm, particularly penetrating deep periodontal tissue. Regular therapeutic strategies are insufficient to penetrate without disturbing commensal microflora of oral cavity. Here, we constructed a Fe 3 O 4 magnetic nanoparticle loading minocycline (FPM NPs) biofilm physically and effectively eliminate biofilm. Methods: In order remove effectively, nanoparticles were modified with using co-precipitation method. particle size dispersion characterized by transmission electron microscopy, scanning dynamic light scattering. antibacterial effects examined verify targeting FPM NPs. Confocal laser microscopy was employed check effect + MF develop best NPs treatment strategy. Additionally, investigated in rat models. expression IL-1β, IL-6, TNF-α tissues measured qRT-PCR Western blot. Results: multifunctional exhibited intense anti-biofilm activity good biocompatibility. forces could pull FMP against mass kill bacteria biofilms both vivo vitro. integrity bacterial disrupted under motivation field, allowing improved drug penetration performance. inflammation recovered well after Furthermore, be monitored real-time have potentials. Conclusion: exhibit chemical stability novel presents new approach treating provides experimental support magnetic-targeted clinic applications. Keywords: ferromagnetic nanoparticle, periodontitis,

Language: Английский

Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection DOI
Yanling Hu,

Xiaohong Ruan,

Xinyi Lv

et al.

Nano Today, Journal Year: 2022, Volume and Issue: 46, P. 101602 - 101602

Published: Sept. 1, 2022

Language: Английский

Citations

130
Secondary Amine Pendant β-Peptide Polymers Displaying Potent Antibacterial Activity and Promising Therapeutic Potential in Treating MRSA-Induced Wound Infections and Keratitis DOI
Yuxin Qian, Shuai Deng, Zihao Cong

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(4), P. 1690 - 1699

Published: Jan. 10, 2022

Interest in developing antibacterial polymers as synthetic mimics of host defense peptides (HPDs) has accelerated recent years to combat antibiotic-resistant bacterial infections. Positively charged moieties are critical defining the activity and eukaryotic toxicity HDP mimics. Most examples have utilized primary amines or guanidines source positively moieties, inspired by lysine arginine residues HDPs. Here, we explore impact amine group variation (primary, secondary, tertiary amine) on performance HDP-mimicking β-peptide polymers. Our studies show that a secondary ammonium is superior either cationic moiety The optimal polymer, homopolymer bearing amino groups, displays potent highest selectivity (low hemolysis cytotoxicity). polymer against bacteria high therapeutic efficacy treating MRSA-induced wound infections keratitis well low acute dermal corneal epithelial cytotoxicity. This work suggests may be broadly useful design

Language: Английский

Citations

99
Multifunctional hydrogel with reactive oxygen species scavenging and photothermal antibacterial activity accelerates infected diabetic wound healing DOI

Yuanmeng He,

Kaiyue Liu,

Shen Guo

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 155, P. 199 - 217

Published: Nov. 17, 2022

Language: Английский

Citations

96
Biofilms in Surgical Site Infections: Recent Advances and Novel Prevention and Eradication Strategies DOI Creative Commons
Andriy Hrynyshyn, Manuel Simões, Anabela Borges

et al.

Antibiotics, Journal Year: 2022, Volume and Issue: 11(1), P. 69 - 69

Published: Jan. 7, 2022

Surgical site infections (SSIs) are common postoperative occurrences due to contamination of the surgical wound or implanted medical devices with community hospital-acquired microorganisms, as well other endogenous opportunistic microbes. Despite numerous rules and guidelines applied prevent these infections, SSI rates considerably high, constituting a threat healthcare system in terms morbidity, prolonged hospitalization, death. Approximately 80% human SSIs, including chronic related biofilm-forming bacteria. Biofilm-associated SSIs extremely difficult treat conventional antibiotics several tolerance mechanisms provided by multidrug-resistant bacteria, usually arranged polymicrobial communities. In this review, novel strategies control, i.e., eradicate, biofilms presented discussed, focusing mainly on two attractive approaches: use nanotechnology-based composites natural plant-based products. An overview new therapeutic agents strategic approaches control epidemic pathogenic particularly when present, is alongside combinatorial attempts obtain synergistic effects restore their efficacy biofilm-mediated SSIs. Some detection real-time monitoring systems improve biofilm diagnosis also discussed.

Language: Английский

Citations

76
Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications DOI
Yueming Wu, Kang Chen, Jiangzhou Wang

et al.

Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 141, P. 101679 - 101679

Published: April 23, 2023

Language: Английский

Citations

45
Multifunctional Dual Network Hydrogel Loaded with Novel Tea Polyphenol Magnesium Nanoparticles Accelerates Wound Repair of MRSA Infected Diabetes DOI
Xulin Hu, Jian He,

Liang Qiao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 6, 2024

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infection, caused by impaired glucose metabolism in diabetic foot patients, poses a significant obstacle to the healing process and carries high risk of being life‐threatening. Due microvascular occlusion entrenchment MRSA biofilms foot, controlling effectively treating infection remains challenging. Traditional hydrogels suffer from swelling‐related mechanical issues inadequate drug release control, limiting their applications as biomimetic extracellular matrices for wound healing. Herein, double‐network hydrogel composed polyvinyl alcohol, sodium alginate, gelatin (PSG) loaded with tea polyphenol self‐assembled magnesium nanoparticles (TP‐Mg NPs) antibacterial angiogenic properties MRSA‐infected wounds under hyperglycemic conditions is constructed. TP‐Mg@PSG exhibits enhanced strength toughness attachment recovery movement torsion. In acidic microenvironment representative wounds, degrades TP‐Mg NPs, showing excellent anti‐MRSA effect biocompatibility. Such localized controlled enhances inhibition reduces inflammatory response rats, promoting cell proliferation rapid repair. Therefore, this study presents multifunctional biomaterial system managing conditions, highlighting its potential clinical applications.

Language: Английский

Citations

38
Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives DOI Open Access

Jingai Jiang,

Xinyi Lv,

Huijuan Cheng

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 1 - 19

Published: Feb. 7, 2024

Language: Английский

Citations

36
Liposomal drug delivery strategies to eradicate bacterial biofilms: Challenges, recent advances, and future perspectives DOI Creative Commons
Vijay Kumar Panthi, Kathryn E. Fairfull‐Smith, Nazrul Islam

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 124046 - 124046

Published: March 29, 2024

Typical antibiotic treatments are often ineffectual against biofilm-related infections since bacteria residing within biofilms have developed various mechanisms to resist antibiotics. To overcome these limitations, antimicrobial-loaded liposomal nanoparticles a promising anti-biofilm strategy as they demonstrated improved delivery and eradication of in biofilms. Antibiotic-loaded revealed remarkably higher antibacterial activities than free drugs experimental settings. Moreover, can be used efficaciously for the combinational antibiotics other antimicrobial compounds/peptide which facilitate, instance, significant breakdown biofilm matrix, increased bacterial elimination from depletion metabolic activity pathogens. Drug-loaded liposomes mitigated recurrent considered tool address challenges associated resistance. Furthermore, it has been that surface charge polyethylene glycol modification notable impact on their activity. Future investigations should tackle persistent hurdles with development safe effective clinical application investigate novel treatments, including CRISPR-Cas gene editing, natural compounds, phages, nano-mediated approaches. Herein, we emphasize significance inhibition biofilms, challenges, recent advances, future perspectives.

Language: Английский

Citations

19
Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases DOI Creative Commons
Lorena Horvat Aleksijević, Marko Aleksijević, Ivana Škrlec

et al.

Pathogens, Journal Year: 2022, Volume and Issue: 11(10), P. 1173 - 1173

Published: Oct. 11, 2022

Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral cavity. It an integral part of microbiome, which includes more than 500 types bacteria. Under certain circumstances, as consequence virulence factors, it can become very destructive and proliferate to many cells periodontal lesions. one causative agents present extremely often dental plaque main etiological factor development disease. During various therapeutic procedures, P. enter blood disseminate through distant organs. This primarily refers influence on subacute endocarditis facilitate coronary heart disease, atherosclerosis, ischemic infarction. The action facilitated by numerous factors pathogenicity such fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, gingipains. A special problem possibility biofilm formation. 1000 times less sensitive antimicrobial drugs planktonic cells, represents significant treatment infections caused this pathogen.

Language: Английский

Citations

58
Three lines of defense: A multifunctional coating with anti-adhesion, bacteria-killing and anti-quorum sensing properties for preventing biofilm formation of Pseudomonas aeruginosa DOI
Yi Zou, Chunxia Liu, Haixin Zhang

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 151, P. 254 - 263

Published: Aug. 9, 2022

Language: Английский

Citations

44