Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(12), P. 809 - 809
Published: Nov. 21, 2024
In
this
paper,
we
present
a
novel
class
of
hybrid
polyketides,
tenuazamines
A–H
(1–8),
which
exhibit
unique
tautomeric
equilibrium
from
Alternaria
alternata
FL7.
The
elucidation
the
structures
was
achieved
through
diverse
combination
NMR,
HR-ESIMS,
and
ECD
methods,
with
focus
on
extensive
spectroscopic
data
analysis.
Notably,
compounds
1,
4,
8–9
exhibited
potent
toxic
effects
growth
Arabidopsis
thaliana.
This
research
expands
structural
diversity
tenuazonic
acid
derived
endophytic
fungi
provides
potential
hit
for
development
herbicides.
Archives of Toxicology,
Journal Year:
2024,
Volume and Issue:
98(6), P. 1659 - 1683
Published: April 25, 2024
Abstract
Alternaria
species
are
mycotoxin-producing
fungi
known
to
infect
fresh
produce
and
cause
their
spoilage.
Humans
get
exposed
fungal
secondary
metabolites
as
mycotoxin
via
the
ingestion
of
contaminated
food.
Alternariol
(AOH)
(C
14
H
10
O
5
)
is
an
isocoumarins
produced
by
different
including
alternata
.
AOH
often
found
in
grain,
fruits
fruits-based
food
products
with
high
levels
legumes,
nuts,
tomatoes.
was
first
discovered
1953,
it
nowadays
linked
esophagus
cancer
endocrine
disruption
due
its
similarity
estrogen.
Although
considered
emerging
no
regulated
food,
occurs
highly
consumed
dietary
has
been
detected
various
masked
forms,
which
adds
occurrence.
Therefore,
this
comprehensive
review
developed
give
overview
on
recent
literature
field
AOH.
The
current
study
summarizes
published
data
occurrence
last
ten
years
evaluates
those
comparison
recommended
regulating
entities.
Such
surveillance
facilitates
work
health
risk
assessors
highlights
commodities
that
most
need
regulation.
In
addition,
effects
cells
animal
models
were
summarized
two
tables;
include
two-year
studies.
addresses
also
main
characteristics
possible
human
exposure
routes,
populations
at
risk,
effect
anthropogenic
activities
widespread
mycotoxin.
commonly
used
detection
control
methods
described
latest
discussed
guide
future
researchers
focus
mitigating
mycotoxins
contamination
industry.
This
aims
mainly
serve
a
guideline
for
regulation
developers
assessors.
Food Chemistry X,
Journal Year:
2025,
Volume and Issue:
25, P. 102167 - 102167
Published: Jan. 1, 2025
The
contamination
of
Alternaria
toxins
poses
a
potential
risk
to
human
health.
This
study
developed
rapid,
efficient,
and
environmentally
friendly
method
for
the
simultaneous
determination
five
types
in
wheat
using
high-precision
stable
isotope
liquid
chromatography
tandem
mass
spectrometry.
comparison
between
dilution
solid-phase
extraction
shows
that
former
achieves
satisfactory
results
with
simple
convenient
sample
purification
method.
quantitative
limit
range
is
0.88
1.68
μg/kg.
recoveries
are
81.40%
102.68%,
RSD
less
than
11.95%.
was
used
analyze
60
samples
from
main
producing
areas
China.
showed
Tenuzonic
acid
had
highest
detection
rate
(100%),
followed
by
Tentoxin
(95%),
Alternariol
(66.67%),
monomethyl
ether
(53.33%).
There
certain
pollution
needs
be
taken
seriously
monitoring
should
strengthened.
Toxicon X,
Journal Year:
2024,
Volume and Issue:
21, P. 100186 - 100186
Published: Feb. 15, 2024
Alternaria
species
produce
several
mycotoxins,
such
as
alternariol
(AOH),
monomethyl
ether
(AME),
altenuene
(ALT),
altertoxin
(ATX),
tentoxin
(TTX)
and
tenuazonic
acid
(TeA).
This
research
aimed
to
isolate
identify
mycotoxins
from
highly
toxic
alternata
(w19)
A.
tennuisima
isolates
their
phytotoxicity
effects.
Fungal
metabolites
were
extracted
21-day
cultures
of
in
a
Czapek
broth
medium
with
the
organic
solvent
chloroform/acetone
identified
using
HPLC
method.
infiltrated
vivo
into
plant
leaves
for
detection.
The
study
investigated
impact
temperature,
time,
metabolite
concentration
on
detached
leaf
infiltration
technique.
Five
(TTX,
TeA,
ALT,
AOH,
AME)
detected
W19
959.24,
102.03,
24.01,
9.04,
2.44
ppm,
respectively.
these
toxins
lower
concentration.
Infiltration
fungal
induced
chlorosis
necrosis,
which
differs
based
species.
Based
our
knowledge,
this
is
first
report
Iran
rapid
wide
range
susceptible
hosts.
