A Crucial Role of Proteolysis in the Formation of Intracellular Dinitrosyl Iron Complexes DOI Creative Commons
Karolina Wójciuk, Jarosław Sadło, Hanna Lewandowska

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1630 - 1630

Published: April 5, 2024

Dinitrosyl iron complexes (DNICs) stabilize nitric oxide in cells and tissues constitute an important form of its storage transportation. DNICs may comprise low-molecular-weight ligands, e.g., thiols, imidazole groups chemical compounds with low molecular weight (LMWDNICs), or high-molecular-weight peptides proteins (HMWDNICs). The aim this study was to investigate the role low- ligands DNIC formation. Lysosomal proteasomal proteolysis inhibited by specific inhibitors. Experiments were conducted on human erythroid K562 overexpressing a heavy chain ferritin. Cell cultures treated •NO donor. formation monitored electron paramagnetic resonance. Pretreatment inhibitors diminished intensity changed shape DNIC-specific EPR signal treatment time-dependent manner. level significantly influenced presence protein degradation products. Interestingly, HMWDNICs depended availability LMWDNICs. extent glutathione involvement vivo is minor yet noticeable, aligning our prior research findings.

Language: Английский

Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis DOI
Yuwu Chen, Xing Luo,

Biyi Xu

et al.

Cardiovascular Drugs and Therapy, Journal Year: 2022, Volume and Issue: 38(4), P. 819 - 832

Published: Dec. 16, 2022

Language: Английский

Citations

13
Optimization of Citric Acid and EDTA Levels Under Ni Stress Using Rapeseed Brassica napus L. for Phytoremediation DOI
H. Nawaz, Naila Asghar, Aamir Ali

et al.

Water Air & Soil Pollution, Journal Year: 2023, Volume and Issue: 234(4)

Published: March 31, 2023

Language: Английский

Citations

8
Comparative genomic analysis of Cohnella hashimotonis sp. nov. isolated from the International Space Station DOI Creative Commons
Anna Simpson, V. V. Ramprasad Eedara, Nitin K. Singh

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

A single strain from the family Paenibacillaceae was isolated wall behind Waste Hygiene Compartment aboard International Space Station (ISS) in April 2018, as part of Microbial Tracking mission series. This identified a gram-positive, rod-shaped, oxidase-positive, catalase-negative motile bacterium genus Cohnella , designated F6_2S_P_1 T . The 16S sequence places it clade with C. rhizosphaerae and ginsengisoli which were originally plant tissue or rhizosphere environments. closest gyrB matches to are 98.84 93.99% similarity, while core single-copy gene phylogeny all publicly available genomes more closely related Average nucleotide identity (ANI) digital DNA–DNA hybridization (dDDH) values any described species <89 <22%, respectively. major fatty acids for anteiso-C 15:0 (51.7%), iso-C 16:0 (23.1%), (10.5%), is able metabolize wide range carbon compounds. Given results ANI dDDH analyses, this ISS novel within we propose name hashimotonis type (=NRRL B-65657 DSMZ 115098 ). Because no available, study generated whole-genome sequences (WGSs) strains Phylogenetic pangenomic analysis reveals that along two uncharacterized strains, possess shared set 332 clusters not other WGS species, form distinct branching off nanjingensis Functional traits predicted members clade.

Language: Английский

Citations

7
Iron oxide nanoparticles as enhancers of growth-promoting bacteria: a step towards developing nano-biofertilizers DOI
Tatiana Benedetti, Wagner Antonio Tamagno, Elisângela Sordi

et al.

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(7), P. 3053 - 3065

Published: Jan. 1, 2024

Co-inoculation of IONPs and PGPB in the soybean seed treatment improves seedling development shows a viable alternative for use as nano-biofertilizer or improving potential control plant diseases crops.

Language: Английский

Citations

2
Articles on hemorrhagic shock published between 2000 and 2021: A CiteSpace-Based bibliometric analysis DOI Creative Commons
Haoran Ye,

Yuan Du,

Yueting Jin

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(8), P. e18840 - e18840

Published: Aug. 1, 2023

ObjectiveTo conduct a bibliometric analysis of literature on hemorrhagic shock published between 2000 and 2021 with the help Citespace to explore current status, hotspots research trends in this regard, results presented visualized manner.MethodsThe data over past 22 years were retrieved from Web Science (WOS) Core Collection database downloaded as "Full Record Cited References". Cooperative analysis, cluster co-citation burst performed based countries/regions, institutions, journals, authors, keywords through Citespace.ResultsA total 2027 articles retrieved. The number annual publications fluctuated but was generally an upward trend. United States stands out most productive country (989 articles), University Pittsburgh publishing institution (109 SHOCK cited journal (1486 TAO LI author (40 DEITCH EA (261 times citation), frequent keyword (725 occurrence), "traumatic brain injury" covered article clustering (29 articles). revealed Harvard highest strength value Journal Trauma Acute Care Surgery important journal. It also concluded that HASAN B ALAM, AARON M WILLIAMS, LIMIN ZHANG may continue publish high-quality future. In meanwhile, both "protect" "transfusion" considered research.ConclusionsThe has been major contributor publication years, institution, journal, all coming US. Hemorrhagic shock, injury, resuscitation, trauma, models, activation, expression, fluid rats, nitric oxide are hot topics relevant research. According areas related rise directions However, since short-lived fast-changing, researchers should pay more attention development trend field.

Language: Английский

Citations

6
Gaseous signaling molecule H2S as a multitasking signal molecule in ROS metabolism of Oryza sativa under thiocyanate (SCN−) pollution DOI
Yuxi Feng, Peng Tian, Yu-Juan Lin

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 340, P. 122816 - 122816

Published: Oct. 26, 2023

Language: Английский

Citations

6
Lipid ROS- and Iron-Dependent Ferroptotic Cell Death in Unicellular Algae Chlamydomonas reinhardtii DOI Creative Commons
Ramachandran Srinivasan,

Hyo-Shim Han,

Parthiban Subramanian

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 553 - 553

Published: Feb. 8, 2023

The phenomenon of heat stress leading to ferroptosis-like cell death has recently been observed in bacteria as well plant cells. Despite recent findings, the evidence ferroptosis, an iron-dependent remains unknown microalgae. present study aimed investigate if shock could induce reactive oxygen species (ROS) and ferroptotic Chlamydomonas reinhardtii comparison with RSL3-induced ferroptosis. After RSL3 (50 °C) treatments or without inhibitors, cells were evaluated for viability induction biomarkers. Both treatment found trigger death, hallmarks glutathione–ascorbic acid depletion, GPX5 downregulation, mitochondrial dysfunction, increase cytosolic calcium, ROS production, lipid peroxidation, intracellular iron accumulation via heme oxygenase-1 activation (HO-1). Interestingly, preincubated ferroptosis inhibitors (ferrostatin-1 ciclopirox) significantly reduced RSL3- heat-induced by preventing Fe2+ ROS. These findings reveal that affects homeostasis peroxidation metabolism Chlamydomonas, indicating pathways are evolutionarily conserved among eukaryotes.

Language: Английский

Citations

5
Understanding the Physiological Mechanism of Heme Oxygenase for Enhanced Tolerance and Phytoremediation of Cd2+ in Eruca sativa: Co-ordinated Function of Antioxidant Defense System DOI
Lovely Mahawar, G. S. Shekhawat

Journal of Plant Growth Regulation, Journal Year: 2022, Volume and Issue: 42(10), P. 6307 - 6318

Published: Oct. 8, 2022

Language: Английский

Citations

8
Carbon Monoxide Modulates Auxin Transport and Nitric Oxide Signaling in Plants under Iron Deficiency Stress DOI Open Access

Kaiyue Hong,

Yasmina Radani,

Waqas Ahmad

et al.

Phyton, Journal Year: 2023, Volume and Issue: 93(1), P. 45 - 61

Published: Dec. 26, 2023

Carbon monoxide (CO) and nitric oxide (NO) are signal molecules that enhance plant adaptation to environmental stimuli.Auxin is an essential phytohormone for growth development.CO NO play crucial roles in modulating the plant's response iron deficiency.Iron deficiency leads increase activity of heme oxygenase (HO) subsequent generation CO.Additionally, it alters polar subcellular distribution Pin-Formed 1 (PIN1) proteins, resulting enhanced auxin transport.This alteration, turn, accumulation.Furthermore, enhances ferric chelate reductase (FCR), as well expression Fer-like deficiency-induced transcription factor (FIT) reduction oxidase 2 (FRO2) genes roots.Overexpression long hypocotyl (HY1) gene, which encodes oxygenase, or CO donor treatment resulted basipetal transport, higher FCR activity, FIT FRO2 under Fe deficiency.Here, a potential mechanism proposed: interact with address stress.CO enhancing its accumulation roots up-regulating key iron-related like IRT1.Elevated levels affect signaling, leading greater sensitivity root development.This interplay promotes absorption.Together, these uptake growth, revealing novel aspect physiology adapting stress.

Language: Английский

Citations

4
Melatonin–Nitric Oxide Interaction Modulates Catalase Activity and Hydrogen Peroxide Homeostasis in Sunflower Seedling Cotyledons Accompanying NaCl Stress DOI
Harmeet Kaur,

Satish C. Bhatla

Journal of Plant Growth Regulation, Journal Year: 2022, Volume and Issue: 42(10), P. 6261 - 6272

Published: Oct. 5, 2022

Language: Английский

Citations

7