Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 227, P. 179 - 189
Published: Dec. 4, 2024
Language: Английский
Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211
Published: May 30, 2024
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused
Language: Английский
Citations
75
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(9)
Published: Sept. 22, 2023
Abstract Kidney diseases remain one of the leading causes human death and have placed a heavy burden on medical system. Regulated cell contributes to pathology plethora renal diseases. Recently, with in-depth studies into kidney death, new iron-dependent modality, known as ferroptosis, has been identified attracted considerable attention among researchers in pathogenesis therapeutics treat them. The majority suggest that ferroptosis plays an important role pathologies multiple diseases, such acute injury (AKI), chronic disease, carcinoma. In this review, we summarize recently regulatory molecular mechanisms discuss pathways action various describe protective effect inhibitors against especially AKI. By summarizing prominent roles different progress made studying provide directions strategies for future research summary, ferroptotic factors are potential targets therapeutic intervention alleviate targeting them may lead treatments patients
Language: Английский
Citations
28
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116722 - 116722
Published: May 9, 2024
Ulcerative colitis (UC) is a complex immune-mediated chronic inflammatory bowel disease. It mainly characterized by diffuse inflammation of the colonic and rectal mucosa with barrier function impairment. Identifying new biomarkers for development more effective UC therapies remains pressing task current research. Ferroptosis newly identified form regulated cell death iron-dependent lipid peroxidation. As research deepens, ferroptosis has been demonstrated to be involved in pathological processes numerous diseases. A growing body evidence suggests that pathogenesis associated ferroptosis, regulation provides opportunities treatment. However, specific mechanisms which participates remain fully thoroughly investigated. Therefore, this review, we focus on advances mechanism recent years describe potential role UC. In addition, explore underlying crosslinked pathway between other such as macrophages, neutrophils, autophagy, endoplasmic reticulum stress, gut microbiota Finally, also summarize compounds may act inhibitors future.
Language: Английский
Citations
17
Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(4)
Published: Jan. 9, 2024
Scope Age‐related increases in retinal iron are involved the development of degeneration. The recently discovered iron‐dependent mechanism cell death known as ferroptosis has been linked to a wide range pathologies. However, its role overload‐induced degeneration is still uncertain. Puerarin associated with protection. purpose this research determine how puerarin prevents under overload conditions. Methods and results Models Kunming mice, 661W cell, ARPE‐19 established. Increased deposition significantly worsens pathology, decreases viability, induces ferroptotic changes. mitigates by decreasing excessive through regulation handling proteins lowering lipid peroxidation inhibition cyclooxygenase 2 expression activation nuclear factor‐E2‐related factor (Nrf2) signaling pathway downstream ferroptosis‐related (solute carrier family 7 member 11, glutathione peroxidase 4 heme oxygenase‐1). protective effect on diminished Nrf2‐specific inhibitor ML385. Conclusion These findings suggest targeting may be novel strategy for management exert some ocular benefits attenuating ferroptosis.
Language: Английский
Citations
12
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 97, P. 102308 - 102308
Published: April 12, 2024
Language: Английский
Citations
8
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 27, 2024
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.
Language: Английский
Citations
5
Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(1), P. 50 - 50
Published: Jan. 22, 2025
Purpose: The purpose of this study was to investigate the activated core kinases involved in DNA damage responses (DDR) during ferroptosis retinal pigment epithelial (RPE) cells vitro and their regulatory effects on ferroptosis. Methods: Ferroptosis induced by erastin RPE (iRPE) derived from human umbilical cord mesenchymal stem (hUCMSCs), hUCMSCs, pluripotent cell-derived (iPSC-RPE) cells. CCK8 employed measure cell viability. Calcein/PI staining used detect ferroptotic γ-H2AX, 8-oxoG, phosphorylated DNA-dependent protein kinase catalytic subunit (DNA-PKcs) were determined through immunostaining. phosphorylation DNA-PKcs ERK1/2 Western blotting. Lipid peroxides detected BODIPY581/591-C11 staining. Results: iRPE exhibited a stronger ability resist compared hUCMSCs. cells, rapidly treatment erastin. In addition, inhibition promoted suggesting that prevents Meanwhile, inhibited only at early stage induction, whereas played protective role Furthermore, inducing its promoting also verified iPSC-RPE Conclusions: present elucidates key DDR is plays vitro, which will provide new research targets strategies for inhibiting
Language: Английский
Citations
0
Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110280 - 110280
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)
Published: Feb. 21, 2025
Abstract Background Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) is closely related to etiology autosomal recessive Stargardt’s disease (STGD1) and dry age-related macular degeneration (AMD). N -retinylidene- -retinylethanolamine (A2E) a leading component RPE that highly susceptible blue light. Ferroptosis an iron-dependent form non-apoptotic cell death characterized by lipid peroxides lethal level, which plays important role diseases. However, it remains unknown whether A2E functions as physiological trigger for eliciting light-induced ferroptosis cells. Methods A2E-loaded cells Abca4 −/− Rdh8 mice were exposed light, respectively. Western blotting, immunofluorescence staining, reactive oxygen species (ROS) intracellular iron peroxidation fundus imaging, optical coherence tomography (OCT), hematoxylin–eosin (HE) electroretinography (ERG) utilized elucidate light induced its potential mechanisms. Results Exposure promoted ferroptotic elevating ferrous ion (Fe 2+ ) levels inhibiting solute carrier family 7 membrane 11 (SLC7A11)-glutathione (GSH)-glutathione peroxidase 4 (GPX4) axis. GPX4 inactivation ROS generated Fe overload GSH depletion precipitated subsequent A2E-containing upon exposure In addition supplement, repressing either deferiprone (DFP) or with ferrostatin-1 (Fer-1) significantly protected against caused illumination A2E. featured accelerated deposition animal model STGD1 AMD. It was observed indeed present following Notably, alleviating intraperitoneally injected Fer-1 effectively rescued function ameliorated RPE/photoreceptor light-exposed mice. Conclusions Our results suggest importance A2E-mediated RPE, deeply broaden understanding mechanisms underlying atrophy arising from
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 18, 2025
Hyperoxia therapy is a critical clinical intervention for both acute and chronic illnesses. However, prolonged exposure to high-concentration oxygen can cause lung injury. The mechanisms of hyperoxic injury (HLI) remain incompletely understood, current treatment options are limited. Improving the safety hyperoxia has thus become an urgent priority. Ferroptosis, novel form regulated cell death characterized by iron accumulation excessive lipid peroxidation, been implicated in pathogenesis HLI, including diffuse alveolar damage, vascular endothelial injury, bronchopulmonary dysplasia. In this review, we analyze latest findings on ferroptosis therapeutic strategies HLI. Our aim provide new insights HLI facilitate translation these from bench bedside.
Language: Английский
Citations
0