Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100560 - 100560
Published: Dec. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 23, 2024
Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.
Language: Английский
Citations
20
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 952, P. 175875 - 175875
Published: Aug. 30, 2024
Language: Английский
Citations
7
Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2832 - 2832
Published: June 14, 2024
This study investigated the mechanism by which fucoxanthin acts as a novel ferroptosis inducer to inhibit tongue cancer. The MTT assay was used detect inhibitory effects of on SCC-25 human squamous carcinoma cells. levels reactive oxygen species (ROS), mitochondrial membrane potential (MMP), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and total iron were measured. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) Western blotting assess peroxidase 4 (GPX4), nuclear factor erythroid 2-related 2 (Nrf2), Keap1, solute carrier family 7 member 11 (SLC7A11), transferrin receptor protein 1 (TFR1), p53, heme oxygenase (HO-1) expression. Molecular docking performed validate interactions. Compared with control group, activity fucoxanthin-treated cells significantly decreased in dose- time-dependent manner. MMP, GSH, SOD cells; ROS, MDA, increased. mRNA expression GPX4, Nrf2, HO-1 decreased, whereas TFR1 p53 increased, concentration-dependent analysis revealed that binding free energies SLC7A11, HO-1, below -5 kcal/mol, primarily based active site hydrogen bonding. Our findings suggest can induce cells, highlighting its treatment for
Language: Английский
Citations
4
International Journal of Endocrinology, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Background: This study aimed to investigate the potential mechanisms of puerarin in alleviating diabetic nephropathy (DKD) mice. Method: The DKD model was induced by multiple low-dose injections streptozotocin (STZ) and a high-sugar high-fat diet male C57BL/6J After confirming onset DKD, mice were given irbesartan, distilled water, or different concentrations (40 80 mg/kg/d) gavage for 8 weeks. HE staining PAS adopted assess pathological changes kidney tissues. Meanwhile, levels superoxide dismutase, catalase, creatinine, cystatin C serum urine albumin creatinine measured, renal indices as well urinary albumin-to-creatinine ratio (UACR) calculated. podocin protein expression associated with AMPK/Nrf2 signaling pathway evaluated western blot. Results: Puerarin significantly reduced level fasting blood glucose, index, glomerular mesangial expansion function, oxidative stress STZ (p < 0.05). injuries tissues also alleviated. Furthermore, we demonstrated that related decreased treatment puerarin. At same time, efficacy better than effect high-dose group (80 mg/kg/d). Conclusion: could attenuate severity protect podocyte dose-dependent way. Also, it might be performed regulating pathway. These findings may provide theoretical basis updating clinical management DKD.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 11, 2025
Ferroptosis, an iron-dependent form of regulated cell death, is characterized by the lethal accumulation lipid peroxides on cellular membranes. It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition cystine-glutamate antiporter, system Xc-, induces ferroptosis. Imidazole ketone erastin (IKE), inhibitor Xc- functional subunit solute carrier family 7 member 11 (SLC7A11), effective metabolically stable inducer ferroptosis with potential vivo applications. However, cells exhibited differential sensitivity to IKE-induced intrinsic factors determining remain be explored improve its efficacy. Bulk RNA-sequencing data from hepatocellular carcinoma (HCC) normal liver tissues were collected Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Differentially expressed genes identified intersected ferroptosis-related (FRGs) listed FerrDb database, yielding identification 13 distinct FRGs. A signature index model (Risk Score) was developed predict HCC prognosis. And SLC7A11 NAD(P)H quinone dehydrogenase 1 (NQO1) as candidate FRGs indicating poor prognosis HCC. Dicoumarol (DIC), NQO1, subsequently employed assess sensitizing effects IKE treatment. In lines subcutaneous xenograft model, combined suppression NQO1 significantly enhanced inhibitory effect inducing conclusion, our findings demonstrate that DIC sensitized Moreover, drugs enhance susceptibility could provide novel therapeutic strategies for treatment
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 986 - 986
Published: April 17, 2025
Iron homeostasis plays an important role in maintaining cellular homeostasis; however, excessive iron can promote the production of reactive oxygen species (ROS). Ferroptosis is iron-dependent programmed cell death that characterized by accumulation, elevated lipid peroxides, and overproduction ROS. The maintenance contingent upon activity transferrin receptor (TfR), ferritin (Ft), ferroportin (FPn). In retina, accumulation peroxidation contribute to development age-related macular degeneration (AMD). This phenomenon be explained occurrence Fenton reaction, which interaction between divalent hydrogen peroxide leads generation highly hydroxyl radicals. radicals exhibit a propensity attack proteins, lipids, nucleic acids, carbohydrates, thereby instigating oxidative damage promoting peroxidation. Ultimately, these processes culminate retinal degeneration. this context, comprehensive understanding exact mechanisms underlying ferroptosis may hold significant importance for developing therapeutic interventions. review summarizes recent findings on metabolism, ferroptosis, metabolism aging retina. We also introduce developments strategies using chelating agents. Further refinements knowledges would deepen our comprehension pathophysiology AMD advance clinical management degenerative retinopathy. A search strategy was employed identify relevant studies AMD. performed systematic searches PubMed Web Science electronic databases from inception current date. keywords used included “ferroptosis”, “AMD”, “age-related degeneration”, “iron metabolism”, “oxidative stress”, “ferroptosis pathways”. Peer-reviewed articles, including original research, reviews, meta-analyses, studies, were paper, with focus molecular AMDs. Studies not directly related or stress context excluded. Furthermore, articles lacked sufficient data peer-reviewed (e.g., conference abstracts, editorials, opinion pieces) considered.
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117319 - 117319
Published: Aug. 27, 2024
Metabolic diseases (MetD) such as diabetes mellitus, obesity, and hyperlipidemia have become global health challenges. As a naturally occurring plant component, puerarin has been verified to possess wide range of pharmacological effects including lowering blood glucose, improving insulin resistance, regulating lipid metabolism, which attracted extensive attention in recent years, its potential the treatment MetD highly acclaimed. In addition, exhibited antioxidant, anti-inflammatory, cardiovascular protective effects, are great significance prevention MetD. This article comprehensively summarizes research progress explores mechanisms, clinical applications, future perspectives. More importantly, this review provided list involved molecular mechanims treating puerarin. Taking into account these conclusions, it may provide strong foundation for optimized use patients suffering from
Language: Английский
Citations
3
Experimental Eye Research, Journal Year: 2024, Volume and Issue: 246, P. 110021 - 110021
Published: Aug. 6, 2024
Language: Английский
Citations
2
Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3530 - 3530
Published: Oct. 18, 2024
As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more attention these days. It a tradition in many regions to intake medicinal herbal food for potential health benefits various organs systems including the kidney. Kidney diseases usually lack targeted therapy face irreversible loss of function, leading dialysis dependence. most important organ endogenous metabolite exogenous nutrient excretion, status kidney could be closely related daily diet. Therefore, rich antioxidative, anti-inflammation micronutrients are ideal supplements protection. Recent studies have also discovered its impact on "gut-kidney" axis.
Language: Английский
Citations
1
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(24)
Published: Dec. 1, 2024
Despite improvements in interventional techniques leading to faster myocardial reperfusion postmyocardial infarction, there has been a significant rise the occurrence of ischaemia/reperfusion injury (MI/RI). A deeper understanding underlying mechanisms MI/RI could offer crucial approach reducing damage and enhancing patient outcomes. This study examined protective properties puerarin (PUE) context using hypoxia/reoxygenation (H/R) or (I/R) models were employed H9c2 cells C57BL/6 mice. Our findings demonstrate that pretreatment with PUE effectively mitigated cardiomyocyte ferroptosis, restored redox balance, preserved mitochondrial energy production maintained function following MI/RI. Furthermore, these cardioprotective effects found be mediated by downregulation voltage-dependent anion channel 1 (VDAC1) protein. These data reveal novel mechanism which inhibits this effect is dependent on VDAC1.
Language: Английский
Citations
1