Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Type 2 diabetes mellitus is a chronic metabolic disease characterized by insulin resistance, with high morbidity and mortality worldwide. Due to the tightly intertwined connection between resistance pathway PI3K/AKT signaling pathway, regulating its associated targets essential for hypoglycemia prevention of type mellitus. In recent years, metabolites isolated from traditional Chinese medicine has received more attention acceptance superior bioactivity, safety, fewer side effects. Meanwhile, numerous in vivo vitro studies have revealed that present possess better bioactivities balance glucose metabolism, ameliorating preventing via pathway. this article, we reviewed literature related improving IR possessing therapeutic potential targeting focusing on hypoglycemic mechanism elaborating significant role order provide reference clinical treatment

Language: Английский

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Bioactive Evaluation of Naringenin in Ameliorating Hyperuricemia‐Induced Liver Injury by Inhibiting Xanthine Oxidase

eFood, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 3, 2025

ABSTRACT Hyperuricemia (HUA) is one of main risk factors for liver injury, and xanthine oxidase (XOD) an important target HUA‐induced injury. As a typical natural active ingredient, naringenin (NAR) has been confirmed the good therapeutic effect on variety diseases. However, studies NAR ameliorating injury have not reported. Therefore, we evaluated bioactivity in investigated related molecular mechanisms. The inhibitory activity type XOD was by enzymatic reactions kinetic analyses, docking showed that able to bind tightly XOD. In vivo ameliorated function while being inhibit activity. alleviated oxidative stress caused excess reactive oxygen species through antioxidant At same time, exerted anti‐inflammatory regulating levels inflammatory factors. results suggested interact with Keap1 AMPK exhibit effects. This work demonstrated which valuable further development functional foods.

Language: Английский

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Ameliorative effects of Asiasarum root and rhizome extract on high fat diet‑induced obesity in mice through regulation of the SIRT1/PGC1α/AMPK pathways in muscle and liver tissues

Molecular Medicine Reports, Journal Year: 2025, Volume and Issue: 31(3)

Published: Jan. 24, 2025

Asiasarum root and rhizome (Asarum) is commonly used as a diaphoretic. Due to its warm pungent characteristics in traditional Chinese Korean medicine, it considered having the potential prevent disease. The present study investigated effects of Asarum extract on symptoms obesity mice, regulation energy metabolism liver skeletal muscle tissues. In addition, identify molecular targets signaling pathways involved mechanism action obesity, network pharmacological docking analysis was performed. vitro studies demonstrated that significantly increased expression regulators [sirtuin 1 (SIRT1), peroxisome proliferator‑activated receptor γ coactivator 1‑α (PGC1α), nuclear respiratory factor 1, AMP‑activated protein kinase (AMPK) glucose transporter type 4 (GLUT4)] myogenic regulatory factors (MyoD, myogenin myosin heavy chain) C2C12 myotubes. Furthermore, vivo could reduce increases body weight, levels blood glucose, insulin, total cholesterol, triglycerides low‑density lipoprotein cholesterol sera obese mice. also improved pathological changes pancreatic tissues ratio brown fat mass weight. reversed gastrocnemius activated SIRT1, PGC1α AMPK These findings indicated may exert anti‑obesity effects, such weight loss, decreases lipid metabolite levels, inhibition damage. Using analysis, mechanisms underlying were explored, particularly

Language: Английский

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Naringenin Decreases Retroperitoneal Adiposity and Improves Metabolic Parameters in a Rat Model of Western Diet-Induced Obesity

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 109 - 109

Published: Feb. 8, 2025

Background: Obesity is a multifactorial disease with detrimental effects on health and quality of life; unregulated satiety plays crucial role in food intake obesity development. Naringenin (NAR) has shown beneficial lipid carbohydrate metabolism, although its impact adiposity remains unclear. This study reports Western diet (WD)-induced model rats, wherein 100 mg/kg NAR was administered as an anti-obesity agent for 8 weeks; oxidative stress, profile, biomarkers were then studied, well silico interaction between cholecystokinin (CCK) ghrelin receptors. Results: supplementation resulted significant decrease retroperitoneal adipose tissue liver weight, compared to the untreated WD group (p < 0.05), potentially associated decreased feed efficiency. also inhibited development dyslipidemia, particularly by reducing serum triglycerides 0.05). increased CCK levels basal group, effect that abolished 0.05); likewise, no changes determined > In data shows capable interacting receptors, which suggests potential it modulate hunger/satiety signaling them. Conclusions: We conclude anti-obesogenic may regulate levels, further research still needed.

Language: Английский

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Novel Insights Into Naringenin: A Multifaceted Exploration of Production, Synthesis, Health Effects, Nanodelivery Systems, and Molecular Simulation

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

ABSTRACT Naringenin, a flavonoid widely present in citrus fruits, has garnered considerable attention due to its diverse biological activities and health‐promoting benefits. As research on naringenin advances, the application scope of significantly expanded. This paper provides systematic overview production synthesis methods naringenin, focusing especially green extraction techniques strategies for constructing microbial metabolic engineering. Naringenin not only achieves including antioxidant, antiinflammatory, glucolipid metabolism regulation through multiple mechanisms but also modulates balance gut microbiota, thereby mediating synergistic health effects via host–microbial axis. Given low oral bioavailability various nanodelivery systems have been developed improve bioavailability. Meanwhile, molecular simulation elucidate binding conformation characteristics with receptors at level, providing novel insights into action. In conclusion, this review seeks offer theoretical basis future directions further naringenin.

Language: Английский

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Integrated characterization of arabica coffee husk tea using flavoromics, targeted screening, and in silico approaches

Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101556 - 101556

Published: June 18, 2024

This study aimed to identify the key volatile compounds in two types of processed arabica coffee husk tea, elucidate their olfactory characteristics, and investigate antioxidant anti-inflammatory activities. Sensory evaluation indicated differences between groups. A total 64 99 were identified C FC groups, respectively, with 5 as aroma (ROAV≥1). Molecular simulations that four common successfully docked OR1A1 OR5M3 receptors, forming stable complexes. Furthermore, 14 interacted 140 targets associated oxidation inflammation, linking 919 gene ontology (GO) terms 135 kyoto encyclopedia genes genomes (KEGG) pathways. revealed these components showed effects by interacting core receptors through several forces, including van der Waals, Pi-alkyl, Pi-cation interactions hydrogen bonds.

Language: Английский

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Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer’s Disease

Current Medical Science, Journal Year: 2024, Volume and Issue: 44(5), P. 867 - 882

Published: Sept. 30, 2024

Language: Английский

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Exercise-regulated lipolysis: Its role and mechanism in health and diseases

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Antiobesity Drug Discovery Research: In vitro Models for Shortening the Drug Discovery Pipeline

Current Drug Targets, Journal Year: 2024, Volume and Issue: 25(6), P. 388 - 403

Published: March 19, 2024

Obesity is a growing global health problem, leading to various chronic diseases. Despite standard treatment options, the prevalence of obesity continues rise, emphasizing need for new drugs.

Language: Английский

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Exploring the action mechanism of Gegensan in the treatment of alcoholic liver disease based on network pharmacology and bioinformatics

Medicine, Journal Year: 2024, Volume and Issue: 103(25), P. e38315 - e38315

Published: June 21, 2024

Gegensan (GGS) has been reported for the treatment of alcoholic liver disease (ALD), but its therapeutic mechanism is still unclear. This paper aims to determine and targets action GGS on utilizing network pharmacology bioinformatics. The active ingredients in were screened literature databases, common ALD then obtained from public databases construct diagram traditional Chinese medicine-active ingredient targets. Based targets, Gene Ontology enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) performed find target pathways, core out by combining differential protein-protein interaction analysis. Molecular docking was verify binding effect between corresponding ingredients. have 84 91 After subsequent analysis, 10 identified. KEGG analyses showed that main BPs included response lipopolysaccharide, inflammatory response, etc. pathways involved regulation lipid-atherosclerosis pathway pathway, Further molecular CYP1A1, CYP1A2, CXCL8, ADH1C, MMP1, SERPINE1, COL1A1, APOB, their 4 ingredients, Naringenin, Kaempferol, Quercetin, Stigmasterol, a greater potential. above results suggest can regulate lipid metabolism process, alleviate accumulation oxidative stress caused ethanol. study analyzed mechanisms ALD, which provides certain theoretical support further development reference research ALD.

Language: Английский

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