Cited by Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus

The histopathological and functional consequences of microplastic exposure DOI

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Language: Английский

Citations

ROS-mediated PPAR/RXR inhibition contributes to acetochlor-induced apoptosis and autophagy in Ctenopharyngodon idella hepatic cells DOI

Xiaojing Li,

Ruichen Bai,

Yichen Bai

et al.

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 128, P. 684 - 694

Published: Aug. 24, 2022

Language: Английский

Citations

Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen DOI

Xinyu Tang,

Xue Fan,

Tong Xu

et al.

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 37(10), P. 2552 - 2565

Published: July 14, 2022

Plastics are novel environmental pollutants with potential threats to the ecosystem. At least 5.25 trillion plastic particles in environment, of which nanoplastics <100 nm diameter. Polystyrene (PS-NPs) exposure damaged spleen's immune function. Lipopolysaccharide (LPS) induced other toxicants damage cells and organs, triggering inflammation. However, mechanism PS-NPs aggravated LPS-induced spleen injury remains unclear. In this study, or/and LPS mice model was replicated by intraperitoneal injection LPS, were exposed RAW264.7 cells. The histopathological ultrastructural changes observed H&E staining transmission electron microscope. Western Blot, qRT-PCR, fluorescent probes used detect reactive oxygen species (ROS), oxidative stress indicators, inflammatory factors, necroptosis-related indicators results showed that or stress, activated MAPK pathway, eventually caused necroptosis inflammation Compared single treatment group, + group more obvious. Furthermore, ROS inhibitor N-Acetyl-L-cysteine (NAC) significantly inhibited activation mitogen-activated protein kinase (MAPK) signaling pathway co-treatment reducing demonstrated promoted through ROS/MAPK pathway. This study increases data on organism expands research ideas clues.

Language: Английский

Citations

Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation DOI

Qianru Chi, Tongwen Xu,

Yujiao He

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 439, P. 129502 - 129502

Published: July 3, 2022

Language: Английский

Citations

Di-(2-Ethylhexyl) Phthalate and Microplastics Induced Neuronal Apoptosis through the PI3K/AKT Pathway and Mitochondrial Dysfunction DOI

Wenyue Zhang, Xinyue Sun, Xue Qi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(35), P. 10771 - 10781

Published: Aug. 25, 2022

Di-(2-Ethylhexyl) phthalate (DEHP) and microplastics (MPs) have released widespread residues to the environment possess ability cause damage humans animals. However, there are still gaps in study of neurons caused by DEHP MPs mice cerebra whether they combined toxic effects. To investigate underlying mechanism action, were fed 200 mg/kg 10 mg/L vivo. In vitro, NS20Y (CBNumber: CB15474825) cells treated with 25 μM 775 MPs. Next, qRT-PCR western blot analysis performed evaluate PI3K/AKT pathway genes, mitochondrial dynamics-related apoptosis-related GSK-3β its associated mRNA, protein expression. determine pathological changes cerebra, hematoxylin eosin (H&E) staining, transmission electron microscopy, TUNEL staining employed. levels reactive oxygen species (ROS) apoptosis ROS acridine orange/ethidium bromide (AO/EB) flow cytometry performed. Our results demonstrated that function, gene expression through pathway, which eventually led neurons. Moreover, our findings showed a effect on cerebra. facilitate understanding neurotoxic effects help identify important role maintaining normal function protecting cerebrum health.

Language: Английский

Citations

Polystyrene nanoplastics exacerbate lipopolysaccharide-induced myocardial fibrosis and autophagy in mice via ROS/TGF-β1/Smad DOI

Peng Lin,

Tong Xu,

Xue Fan

et al.

Toxicology, Journal Year: 2022, Volume and Issue: 480, P. 153338 - 153338

Published: Sept. 24, 2022

Language: Английский

Citations

Paraquat induces apoptosis, programmed necrosis, and immune dysfunction in CIK cells via the PTEN/PI3K/AKT axis DOI

Xu Shi,

Wenjing Zhu,

Ting Chen

et al.

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 130, P. 309 - 316

Published: Sept. 17, 2022

Language: Английский

Citations

Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR DOI

Hongmin Lu,

Kai Yin,

Heng Su

et al.

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 38(1), P. 78 - 89

Published: Oct. 7, 2022

Microplastics (MPs) seriously pollute and potentially threaten human health. Birds are sentinels of environmental pollutants, which respond quickly to contamination events reveal current exposure. Therefore, birds good bioindicators for monitoring pollutants. However, the mechanism lung injury in role PTEN/PI3K/AKT axis unknown. In this study, broilers treated with different polystyrene microplastics (PS-MPs) (0, 1, 10, 100 mg/L) were exposed drinking water 6 weeks analyze effect PS-MPs on broilers. The results showed that increase concentration, malonaldehyde (MDA) content increased, catalase (CAT) glutathione (GSH) activity decreased, further leading oxidative stress. caused PI3K/Akt/mTOR pathway be inhibited by phosphorylation, autophagy accelerated formation (LC3) degradation (p62), causing autophagy. tissues, expression Bax/Bcl-2 Caspase family MAPK signaling pathways (p38, ERK, JNK) an phosphorylation level, thus cell apoptosis. Our research could activate antioxidant system. system unbalance-regulated family, initiated apoptosis autophagy, turn led tissue damage chickens. These great significance toxicological study protection ecosystem.

Language: Английский

Citations

Microplastic exposure induces muscle growth but reduces meat quality and muscle physiological function in chickens DOI

Jiahui Chen,

Genghua Chen,

Haoqi Peng

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 882, P. 163305 - 163305

Published: April 11, 2023

Language: Английский

Citations

Immunosuppression participated in complement activation-mediated inflammatory injury caused by 4-octylphenol via TLR7/IκBα/NF-κB pathway in common carp (Cyprinus carpio) gills DOI

Qi Sun, Yuhao Liu,

Xiaojie Teng

et al.

Aquatic Toxicology, Journal Year: 2022, Volume and Issue: 249, P. 106211 - 106211

Published: May 31, 2022

Language: Английский

Citations