Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 871, P. 161962 - 161962

Published: Feb. 10, 2023

Language: Английский

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Combined exposure of emamectin benzoate and microplastics induces tight junction disorder, immune disorder and inflammation in carp midgut via lysosome/ROS/ferroptosis pathway

Water Research, Journal Year: 2024, Volume and Issue: 257, P. 121660 - 121660

Published: April 22, 2024

Language: Английский

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Combined negative effects of microplastics and plasticizer DEHP: The increased release of Nets delays wound healing in mice

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 862, P. 160861 - 160861

Published: Dec. 14, 2022

Language: Английский

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Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 131, P. 1075 - 1084

Published: Nov. 14, 2022

Language: Английский

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Nano-selenium protects grass carp hepatocytes against 4-tert-butylphenol-induced mitochondrial apoptosis and necroptosis via suppressing ROS-PARP1 axis

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 135, P. 108682 - 108682

Published: March 14, 2023

Language: Английский

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EGCG alleviated Mn exposure-caused carp kidney damage via trpm2-NLRP3-TNF-α-JNK pathway: Oxidative stress, inflammation, and tight junction dysfunction

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 134, P. 108582 - 108582

Published: Feb. 7, 2023

Language: Английский

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Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(14), P. 5450 - 5462

Published: April 3, 2023

Perfluorooctanesulfonic acid (PFOS), a fluorine-containing organic compound, can be widely detected in the environment and living organisms. Accumulating evidence has shown that PFOS breaks through different biological barriers resulting cardiac toxicity, but underlying molecular mechanisms remain unclear. Cannabidiol (CBD) is nonpsychoactive cannabinoid without potential adverse cardiotoxicity antioxidant anti-inflammatory properties reduce multiorgan damage dysfunction. For these reasons, aim of this study was to research how caused heart injury whether CBD could attenuate PFOS-induced injury. Mice were fed (5 mg/kg) and/or (10 vivo. In vitro, H9C2 cells intervened with (200 μM) μM). After exposure, oxidative stress levels mRNA protein expression apoptosis-related markers increased distinctly, accompanied by mitochondrial dynamic imbalance energy metabolism disorders mouse cells. Moreover, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, acridine orange/ethidium bromide staining Hoechst 33258 signaled number apoptotic after exposure PFOS. Noteworthy, simultaneous treatment alleviated series damages PFOS-mediated stress. Our results demonstrated alleviate dynamics disorder causing cardiomyocyte apoptosis improving capacity, suggesting may represent novel cardioprotective strategy against cardiotoxicity. findings facilitate understanding cardiotoxic effects important role protecting health.

Language: Английский

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ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency

Environmental Pollution, Journal Year: 2023, Volume and Issue: 324, P. 121392 - 121392

Published: March 9, 2023

Language: Английский

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Perfluorooctane sulfonate‐induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol

Environmental Toxicology, Journal Year: 2023, Volume and Issue: 38(7), P. 1651 - 1664

Published: March 29, 2023

Perfluorooctane sulfonate (PFOS) is one of the persistent organic pollutants (POPs), which can cause severe nephrotoxicity in mammals. Cannabinol (CBD), a nonpsychoactive cannabinoid obtained from cannabis plant, has attracted attention recent years for its excellent antioxidant properties. NADPH oxidase 4 (NOX4) an important effect supporting normal renal physiological function. The potential mechanisms PFOS and whether CBD prevent damage caused by remain unclear. This work aimed to study PFOS-induced kidney protective role against damage. We demonstrated that led insufficiency structural mice, induced overexpression NOX4 onset oxidative stress, activated apoptosis mitochondrial pathway via JNK signaling pathway. However, treatment with reversed these changes. For further investigation mechanism cell apoptosis, expression was inhibited vitro experiments using Apocynin, effective inhibitor. outcomes showed ROS production activation human embryonic (HEK293) cells were significantly reduced after inhibition NOX4. suggests serves as upstream event activation. In conclusion, findings suggest induces NOX4/ROS/JNK Meanwhile, alleviated through axis

Language: Английский

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Molecular mechanism of kidney damage caused by abamectin in carp: Oxidative stress, inflammation, mitochondrial damage, and apoptosis

Toxicology, Journal Year: 2023, Volume and Issue: 494, P. 153599 - 153599

Published: July 25, 2023

Language: Английский

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