Mitochondrial transplantation inhibits cholangiocarcinoma cells growth by balancing oxidative stress tolerance through PTEN/PI3K/AKT signaling pathway DOI
Xiaocong Liu, Yuanyuan Zhang, Xiaoyan Yang

et al.

Tissue and Cell, Journal Year: 2023, Volume and Issue: 85, P. 102243 - 102243

Published: Oct. 14, 2023

Language: Английский

Cadmium exposure caused cardiotoxicity in common carps (Cyprinus carpio L.): miR-9-5p, oxidative stress, energetic impairment, mitochondrial division/fusion imbalance, inflammation, and autophagy DOI
Yuhao Liu, Lin Xu, Zhiyu Hao

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 138, P. 108853 - 108853

Published: May 27, 2023

Language: Английский

Citations

52
Micro-algal astaxanthin improves lambda-cyhalothrin-induced necroptosis and inflammatory responses via the ROS-mediated NF-κB signaling in lymphocytes of carp (Cyprinus carpio L.) DOI
Jingzeng Cai,

Pinnan Liu,

Xintong Zhang

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 139, P. 108929 - 108929

Published: July 4, 2023

Language: Английский

Citations

40
Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver DOI Creative Commons

Dongliu Luo,

Jintao Zhang, Hang Yin

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 263, P. 115374 - 115374

Published: Aug. 14, 2023

As a new type of persistent organic pollutant, perfluorooctane sulphonate (PFOS) has received extensive attention worldwide. Cannabidiol (CBD) is non-psychoactive natural cannabinoid extract that been proved to have antioxidation, regulation inflammation and other functions. However, the effects PFOS on liver injury whether CBD can alleviate PFOS-induced are still unclear. Therefore, in this study, we used (10 mg/kg) and/or (5 intraperitoneally inject mice for 30 days. We found exposure led inflammatory infiltration mice, increased formation macrophage extracellular trap (MET), promoted fibrosis. In vitro, established coculture system RAW264.7, AML12 LX-2 cells, treated them with μM) (200 μM). The results showed could also induce expression MET, fibrosis marker genes vitro. Coiled-coil domain containing protein 25 (CCD25), as MET-DNA sensor, was investigate its ability regulate fibrosis, knocked down CCDC25 downstream proteins (integrin-linked kinase, ILK) by siRNA technology, QNZ inhibit NF-κB pathway. knockdown ILK inhibition pathway MET-induced gene expression. summary, MET promote through CCDC25-ILK-NF-κB signaling axis, while treatment protective effect, it Macromolecular docking effect achieved combining peptidylarginine deiminase 4 (PAD4) release MET. regulating axis an innovative option effectively reduce hepatotoxicity. Our study reveals mechanism hepatotoxicity provides promising insights into role process.

Language: Английский

Citations

26
Molecular mechanism of kidney damage caused by abamectin in carp: Oxidative stress, inflammation, mitochondrial damage, and apoptosis DOI
Xinyu Wu,

Yeyun Ma,

Xueqing Li

et al.

Toxicology, Journal Year: 2023, Volume and Issue: 494, P. 153599 - 153599

Published: July 25, 2023

Language: Английский

Citations

24
Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-κB/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney DOI
Shanshan Li,

Xuedie Gu,

Muyue Zhang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171817 - 171817

Published: March 19, 2024

Language: Английский

Citations

14
Astaxanthin Inhibits H2O2-Induced Excessive Mitophagy and Apoptosis in SH-SY5Y Cells by Regulation of Akt/mTOR Activation DOI Creative Commons
Tingting Yan,

Feng Ding,

Yiting Zhang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(2), P. 57 - 57

Published: Jan. 24, 2024

Oxidative stress, which damages cellular components and causes mitochondrial dysfunction, occurs in a variety of human diseases, including neurological disorders. The clearance damaged mitochondria via mitophagy maintains the normal function facilitates cell survival. Astaxanthin is an antioxidant known to have neuroprotective effects, but underlying mechanisms remain unclear. This study demonstrated that astaxanthin inhibited H

Language: Английский

Citations

9
New insights into Microalgal astaxanthin's effect on Lambda-cyhalothrin-induced lymphocytes immunotoxicity in Cyprinus carpio: Involving miRNA-194-5p-FoxO1-mediated-mitophagy and pyroptosis DOI
Jingzeng Cai, Haoyue Guan, Di Li

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 141, P. 109046 - 109046

Published: Sept. 1, 2023

Language: Английский

Citations

21
Irisin protects against doxorubicin-induced cardiotoxicity by improving AMPK-Nrf2 dependent mitochondrial fusion and strengthening endogenous anti-oxidant defense mechanisms DOI

Caili Zhuo,

Juan-Juan Xin,

Wenjing Huang

et al.

Toxicology, Journal Year: 2023, Volume and Issue: 494, P. 153597 - 153597

Published: July 25, 2023

Language: Английский

Citations

19
Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions DOI
Xia Yu, Shanshan Li, Xixi Wang

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 141, P. 109000 - 109000

Published: Aug. 18, 2023

Language: Английский

Citations

15
Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS/P53 DOI

Dongliu Luo,

Xinyu Tang, Yixuan Wang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 913, P. 169730 - 169730

Published: Dec. 30, 2023

Language: Английский

Citations

15