White adipocyte dysfunction and obesity-associated pathologies in humans

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(4), P. 270 - 289

Published: Dec. 12, 2023

Language: Английский

---

Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health

Nature Reviews Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

---

Translational potential of mouse models of human metabolic disease

Cell, Journal Year: 2024, Volume and Issue: 187(16), P. 4129 - 4143

Published: July 26, 2024

Obesity causes significant morbidity and mortality globally. Research in the last three decades has delivered a step-change our understanding of fundamental mechanisms that regulate energy homeostasis, building on foundational discoveries mouse models metabolic disease. However, not all findings made rodents have translated to humans, hampering drug discovery this field. Here, we review how studies mice humans informed current framework for discuss their challenges limitations, offer perspective human may play an increasingly important role disease identification therapeutic targets future.

Language: Английский

---

Emerging debates and resolutions in brown adipose tissue research

Cell Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

---

Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 31, 2024

A high-fat diet and physical inactivity are key contributors to obesity, predisposing individuals various chronic diseases, such as cardiovascular disease diabetes, which involve multiple organs tissues. To better understand the role of multi-organ interaction mechanisms in rising incidence obesity its associated conditions, treatment prevention strategies being extensively investigated. This review examines signaling between different tissues organs, with a particular focus on crosstalk adipose tissue muscle, brain, liver, heart, potentially offers new for management complications.

Language: Английский

---

Exploration of Conserved Human Adipose Subpopulations Using Targeted Single‐Nuclei RNA Sequencing Data Sets

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Background Smooth‐muscle cells and pericytes are mural cells. Pericytes can differentiate into myofibroblasts, chondrocytes, vascular smooth‐muscle cells, adipocytes, marking them as a distinct progenitor population. Our goal was to molecularly define the cell populations in human adipose tissues test adipogenic potential of Methods We used informatic analysis single‐cell RNA sequencing data from identify found tissues, including perivascular, brown, white tissues. Results established tissue‐specific patterns gene expression other putative adipocyte PPARG ‐expressing were present multiple depots with consistent COL25A1 , MYO1B POSTN . also evidence pericyte markers. Although there is some conservation between mouse have unique, depot‐specific signatures. Immunofluorescence staining tissue revealed presence both distant adjacent vasculature tissue. Additionally, we demonstrated brain aortic adipocytes vitro on basis intracellular lipid accumulation Conclusions Human mice, subpopulation across depots. Given that undergo adipogenesis, postulate they novel source microenvironment.

Language: Английский

---

Key Questions and Gaps in Understanding Adipose Tissue Macrophages and Early-Life Metabolic Programming

AJP Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 327(4), P. E478 - E497

Published: Aug. 22, 2024

The global obesity epidemic, with its associated comorbidities and increased risk of early mortality, underscores the urgent need for enhancing our understanding origins this complex disease. It is increasingly clear that metabolism programmed in life metabolic programming can have life-long health consequences. As a critical organ sensitive to early-life stimuli, proper development adipose tissue (AT) crucial energy homeostasis. Early-life nutrients, especially fatty acids (FAs), significantly influence AT shape function metabolism. Of growing interest are dynamic responses during pre- postnatal proinflammatory omega-6 (

Language: Английский

---

Adipose ‘neighborhoods’ collaborate to maintain metabolic health

Current Opinion in Genetics & Development, Journal Year: 2023, Volume and Issue: 81, P. 102079 - 102079

Published: July 3, 2023

Language: Английский

---

Everything you wanted to know about pancreatic ducts but didn’t know where to look

Gastroenterology, Journal Year: 2024, Volume and Issue: 167(5), P. 845 - 847

Published: July 31, 2024

Language: Английский

---