Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 339 - 352
Published: Dec. 6, 2024
Language: Английский
Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 10
Published: Jan. 8, 2024
Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, treatment option for HFpEF still limited, indicating our ongoing incomplete understanding on underlying molecular mechanisms. Non-coding RNAs, comprising microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular (circRNAs), are non-protein coding RNA transcripts, which implicated various diseases. However, their role pathogenesis unknown. Here, we discuss miRNAs, lncRNAs circRNAs that involved pathophysiology HFpEF, namely microvascular dysfunction, inflammation, diastolic dysfunction cardiac fibrosis. We interrogated evidence dissected mechanisms ncRNAs by looking at relevant vivo vitro models mimic co-morbidities patients HFpEF. Finally, potential as biomarkers novel therapeutic targets future treatment.
Language: Английский
Citations
8
Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 906 - 906
Published: April 8, 2025
According to the literature, cardiovascular diseases (CVDs)—including myocardial infarction, stroke, and venous thromboembolism (VTE)—are among leading causes of mortality morbidity worldwide. Evidence suggests that CVDs share common risk factors pathophysiological mechanisms. Similar Mosaic Theory Hypertension proposed by Irvine Page in 1949, pathophysiology VTE is multifactorial, involving multiple interacting processes. The concept immunothrombosis, introduced Engelmann Massberg 2009, describes interplay between immune system thrombosis. Both thrombosis hemostasis core mechanisms, including platelet activation fibrin formation. Additionally, mediators—such as monocytes, neutrophil extracellular traps (NETs), lymphocytes, selectins, various molecular factors—play a critical role thrombus This review highlights inflammation key factor for pulmonary embolism (APE). Immunity central complex interactions coagulation cascade, platelets, endothelium, reactive oxygen species (ROS), genetic factors. Specifically, we examine roles cells, microRNAs (miRNAs) APE explore potential therapeutic targets. aims elucidate miRNAs future perspective.
Language: Английский
Citations
0
BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 9, 2025
Circular RNAs (circRNAs) and microRNAs (miRNAs) interactions have essential implications in various biological processes diseases. Computational science approaches emerged as powerful tools for studying predicting these intricate molecular interactions, garnering considerable attention. Current methods face two significant limitations: the lack of precise interpretable models insufficient representation homogeneous heterogeneous molecules. We propose a novel method, MFERL, that addresses both limitations through multi-scale learning an explainable fine-grained model circRNA-miRNA (CMI). MFERL learns representations by aggregating node features interacting with features, well dual-convolution attention mechanisms contrastive to enhance features. utilize manifold-based method examine performance detail, revealing exhibits robust generalization, robustness, interpretability. Extensive experiments show outperforms state-of-the-art offers promising direction understanding CMI intrinsic mechanisms.
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5723 - 5740
Published: Aug. 1, 2024
Primary Sjögren's syndrome (pSS) is an autoimmune condition marked by lymphocyte infiltration in the exocrine glands. Our study aimed to identify a novel biomarker for pSS improve its diagnosis and treatment.
Language: Английский
Citations
2
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 257, P. 155281 - 155281
Published: April 1, 2024
Language: Английский
Citations
2
Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 39(7), P. 1299 - 1309
Published: April 22, 2024
Circular RNA (circRNA) has been found to mediate ulcerative colitis (UC) progression by regulating intestinal mucosal barrier function. However, the role of circSOD2 in UC process and its underlying molecular mechanism still need be further elucidated.
Language: Английский
Citations
1
Cartilage, Journal Year: 2024, Volume and Issue: unknown
Published: May 15, 2024
Objective Knee osteoarthritis (KOA) is a complex degenerative joint disease and major cause of dysfunction. This study aimed to explore the function hsa_circ_0007482 on inflammation, proliferation, differentiation, apoptosis in KOA. Design Real-time quantitative polymerase chain reaction (PCR) was performed detect expression circ_0007482, inflammatory factors, differentiation-related molecules KOA chondrocytes interleukin (IL)-1β–stimulated chondrocytes. The correlation between circ_0007482 factors analyzed by Pearson method. cell model established using IL-1β for 24 hours. proliferation activity evaluated CCK-8 assay, rate assessed flow cytometry. downstream miRNA validated dual-luciferase reporter assay. Results elevated both cartilage tissues IL-1β–treated positively correlated with expression. In comparison control group, treatment diminished chondrocyte abilities increased IL-6, IL-8, tumor necrosis factor (TNF)-α mRNA Inhibition partially improved IL-1β–induced reaction. Circ_0007482 could negatively regulate miR-558. Conclusions Interfering might promote while inhibit improve injury regulating miR-558 model.
Language: Английский
Citations
1
Hereditas, Journal Year: 2024, Volume and Issue: 161(1)
Published: Nov. 18, 2024
Abstract Infertility is a global problem being associated with emotional and financial burden. Recent studies have shown contribution of group non-coding RNAs, namely circular RNAs (circRNAs) to the etiology some infertility conditions. CircRNA are transcribed from exons form RNA molecule, abundant in eukaryotes. Traditionally classified as RNA, these transcripts endogenously produced through either non-canonical back-splicing or linear splicing, typically precursor messenger ribonucleic acid (pre-mRNA). While during canonical splicing process 3’ end exon joined 5’ succeeding mRNA, backsplicing, same make molecule. circRNAs involved regulation several aspects spermatogenesis. They appear influence how stem germ cells grow divide sperm production process. Malfunctions circRNA activity could contribute male issues stemming abnormalities In current review, we highlight exciting potential key players fertility.
Language: Английский
Citations
1
Veterinary Research Communications, Journal Year: 2024, Volume and Issue: 49(1)
Published: Nov. 26, 2024
Language: Английский
Citations
1
World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(1), P. 145 - 158
Published: Jan. 22, 2024
BACKGROUND Emerging research suggests that microRNAs (miRNAs) play an important role in the development of hepatocellular carcinoma (HCC). A comprehensive analysis recent concerning miRNAs HCC could provide researchers with a valuable reference for further studies. AIM To make studies HCC. METHODS All relevant publications were retrieved from Web Science Core Collection database. Bibliometrix software, VOSviewer software and CiteSpace used to visually analyze distribution by time, countries, institutions, journals, authors, as well keywords, burst keywords thematic map. RESULTS total 9426 on this topic found worldwide. According analysis, we focused their expression level, effects, mechanisms biological behaviour Keywords bursting showed early years (2013–2017), “microRNA expression”, “gene “expression profile”, “functional polymorphism”, “circulating microRNA”, “susceptibility” “mir 21” started attract attention. In latest phase (2018–2022), hot topics turned “sorafenib resistance”, “tumor microenvironment” so on. CONCLUSION This study provides overview based bibliometric analysis. The hotspots field focus behavior frontiers sorafenib resistance, tumor microenvironment
Language: Английский
Citations
0