Protective Effects and Mechanism of Sangyu Granule on Acetaminophen-Induced Liver Injury in Mice DOI

Kexin Xiao,

Yuening Li, Hongyu Li

et al.

Published: Jan. 1, 2023

Ethnopharmacological relevance The Sang Yu granule (SY), a traditional Chinese medicine prescription of Xijing Hospital, was developed based on the Guanyin powder in classical "Hong's Collection Proven Prescriptions" and new theory modern medicine. It has been proved to have certain therapeutic effect drug-induced liver injury (DILI), but specific mechanism action is still unclear.Aim study Aim explore SangYu treating mice.Materials methods chemical composition SY, serum, tissue analyzed using ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Kits were utilized measure levels total bile acids, as well activity serum AST, ALT, ALP. ELISA kits employed determine concentrations IL-1β TNF-α content FGF-15 FGF-19 ileal tissue. To assess variance gene expression diversity fecal microbiota among different groups, we conducted Transcriptome Sequencing Analysis 2bRAD-M microbial analysis, respectively. Western blotting performed observe differences activation FXR, SHP, CYP7A1, PPARα genes proteins mice. Additionally, transplantation (FMT) experiments investigate potential administering intestinal suspension from mice treated with SY injury.Results treatment significantly relieved mice, effectively regulating flora disorders injury. Furthermore, administration demonstrated reduction concentration acids an upregulation protein FGF-15, FGF-19. However, no notable impact observed. findings FMT revealed that obtained after did not exhibit any injury.Conclusion Based aforementioned findings, it can be inferred ameliorates by modulating associated acid secretion ensuring maintenance hepatoenteric circulation homeostasis.

Language: Английский

Involvement of intestinal mucosal microbiota in adenine-induced liver function injury DOI

Leyao Fang,

Junxi Shen, Yi Wu

et al.

3 Biotech, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 12, 2024

Language: Английский

Citations

7
Gut–Liver Axis as a Therapeutic Target for Drug-Induced Liver Injury DOI Creative Commons
Wenjing Tao,

Qi-Wen Fan,

Jintao Wei

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(2), P. 1219 - 1236

Published: Feb. 1, 2024

Drug-induced liver injury (DILI) is a disease that remains difficult to predict and diagnose, the underlying mechanisms are yet be fully clarified. The gut–liver axis refers reciprocal interactions between gut liver, its homeostasis plays prominent role in maintaining health. It has been recently reported patients animals with DILI have disrupted axis, involving altered microbiota composition, increased intestinal permeability lipopolysaccharide translocation, decreased short-chain fatty acids production, impaired bile acid metabolism homeostasis. present review will summarize evidence from both clinical preclinical studies about of pathogenesis DILI. Moreover, we focus attention on potential therapeutic strategies for based improving function, including herbs phytochemicals, probiotics, fecal microbial transplantation, postbiotics, acids, Farnesoid X receptor agonists.

Language: Английский

Citations

5
Gut Microbiota as Predictive Biomarker for Chronic Heart Failure in Patients with Different Nutritional Risk DOI
Chen Yang, Xiaopeng Li, Miaomiao Hu

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Language: Английский

Citations

5
Wolfberry, Yam, and Chrysanthemum polysaccharides increased intestinal Akkermansia muciniphila abundance and hepatic YAP1 expression to alleviate DILI DOI Creative Commons

Junlan Lu,

Yi Gong,

Yuting Gao

et al.

The FASEB Journal, Journal Year: 2023, Volume and Issue: 37(12)

Published: Nov. 11, 2023

Drug-induced liver injury (DILI) is frequently induced by high dose of acetaminophen (APAP) and concomitant with disturbances gut flora. Akkermansia muciniphila beneficial for the repair injury. Lycium barbarum polysaccharide, yam chrysanthemum polysaccharide all have anti-inflammatory antioxidation effects. The objective this study to investigate potential lycium (LYC) in improving DILI increasing abundance A. muciniphila. Initially, screening optimal concentrations wolfberry, yam, (WYC) or LYC promote proliferation vitro validated antibiotic (ATB)-treated KM mice. Subsequently, APAP-induced model BALB/c mice were constructed examine treatment effects LYC. Our findings indicate that concentration ratio WYC was 2:3:2, 1:1:1. increased ATB-treated under ratio. Meanwhile, combination promoted overdose APAP resulted impairment intestinal barrier function subsequent leakage lipopolysaccharide (LPS). Moreover, abundance, reduced inflammation permeability, upregulated expression tight junction protein zonula occludens 1 (ZO-1) occludin contents gut. Lastly, inhibited LPS hepatic YAP1 expression, ultimately leading DILI.

Language: Английский

Citations

12
Interplay Between Drug-Induced Liver Injury and Gut Microbiota: A Comprehensive Overview DOI Creative Commons
Guolin Li,

Yifu Hou,

Changji Zhang

et al.

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 18(3), P. 101355 - 101355

Published: Jan. 1, 2024

Recent research has revealed a close association between drug-induced liver injury and gut microbiota.However, the specific mechanism of microbiota involvement in remains unclear.This review examines how interacts with common hepatotoxic drugs its potential role pathogenesis, offering more comprehensive reference for interplay microbiota.

Language: Английский

Citations

4
The association between the gut microbiome and antituberculosis drug-induced liver injury DOI Creative Commons
Shengfei Pei, Yang Li,

Huixia Gao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 10, 2025

Background This study aimed to explore the distinct characteristics of gut microbiota in tuberculosis (TB) patients who experienced liver injury following anti-TB treatment compared with those did not. Method We employed a nested case-control design, recruiting newly diagnosed pulmonary TB at Tangshan Infectious Disease Hospital. Participants were categorized into Antituberculosis Drug-Induced Liver Injury (ADLI) group and Non-ADLI based on occurrence after treatment. Both groups received identical regimens. Stool samples collected from developed within 2–3 weeks starting treatment, alongside matched controls during same timeframe. The underwent 16S rDNA sequencing, clinical data blood also for further analysis. At time, we constructed mouse models effects different anti-tuberculosis drugs microbiota. Results Following observed decrease microbial diversity significant structural changes (P < 0.05). T1, Non_ADLI_T1 presented relatively high levels Phascolarctobacterium , Anaerofustis Mailhella . In contrast, ADLI_ T1 elevated Bacteroides Veillonella Clavibacter Corynebacterium Anaerococcus Gardnerella Peptostreptococcus Lautropia T2, ADLI_T2 increased Enterococcus Faecalibacterium unclassified_f__Burkholderiaceae Cardiobacterium Ruminococcus_gnavus_group Tyzzerella_4 than Non_ADLI_T2 group. Additionally, decreased Prevotella_9 Akkermansia Erysipelotrichaceae_UCG-003, Rubrobacter norank_f__Desulfovibrionaceae animal experiments, similar human population model control Any single drug or two-drug combination three-drug can cause dysbiosis signature genera between are related type drug. Conclusion Anti-tuberculosis induces patients. Notably, there differences without both onset There some bacterial flora caused by drugs.

Language: Английский

Citations

0
Imaging of sulfhydryl fluctuations in mouse models of drug-induced liver injury via a novel near-infrared fluorescence probe DOI
Qiyu Chen,

Ruipeng Shen,

Lijie Mi

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 339, P. 126289 - 126289

Published: April 24, 2025

Language: Английский

Citations

0
Adverse outcome pathway networks as the basis for the development of new approach methodologies: liver toxicity as a case study DOI
Mathieu Vinken

Current Opinion in Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 100504 - 100504

Published: Sept. 1, 2024

Language: Английский

Citations

3
Exploring drug-induced liver injury: comprehensive insights into mechanisms and management of hepatotoxic agents DOI Creative Commons
Asmaa Saleh,

Thanaa A. El‐Masry,

Aya H. El-Kadem

et al.

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 28, 2025

Abstract Background Drug-induced liver injury (DILI) is a significant adverse drug reaction, manifesting through range of clinical presentations from mild enzyme to acute failure. Main text This review provides comprehensive overview DILI, emphasizing the differences between intrinsic and idiosyncratic DILI. The underlying molecular mechanisms, like mitochondrial dysfunction, oxidative stress, immune-mediated responses, are discussed in detail. epidemiology DILI explored various retrospective prospective studies, highlighting role specific medications individual susceptibility factors. also addresses challenges diagnosing impact on development practice. Conclusion poses threat due its potential for causing failure associated mortality. To improve patient outcomes, further research crucial identify effective therapeutic interventions.

Language: Английский

Citations

0
Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature DOI Creative Commons
Palak A. Patel-Rodrigues, Lindsey B. Cundra,

Dalal Alhaqqan

et al.

Livers, Journal Year: 2024, Volume and Issue: 4(1), P. 94 - 118

Published: Feb. 13, 2024

Herbal-induced liver injury (HILI) continues to increase in prevalence each year due the ongoing popularity of herbal supplements and complementary alternative medicines. A detailed literature review case reports clinical studies published from March 2021 2023 was performed. We discuss epidemiology diagnosis HILI as well current proposed laws regulations. The ACG guidelines 2022 AASLD practice for management drug herbal-induced are discussed. describe updates previously reported etiologies such ayurveda, ashwagandha, turmeric, kratom, green tea extract, garcinia cambogia. Newly described resulting HILI, tinospora cordifolia, horse chestnut, alkaline water, more, described. newly identified hepatoprotective they have been study animal models human cells. This suggests need research on causes mechanisms ensure its proper diagnosis, prevention, treatment future. goal this is provide novice expert readers with knowledge regarding possible a general overview.

Language: Английский

Citations

2