International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3133 - 3133
Published: March 8, 2024
The
increasing
demand
for
innovative
approaches
in
wound
healing
and
skin
regeneration
has
prompted
extensive
research
into
advanced
biomaterials.
This
review
focuses
on
showcasing
the
unique
properties
of
sustainable
silk-based
particulate
systems
promoting
controlled
release
pharmaceuticals
bioactive
agents
context
regeneration.
Silk
fibroin
sericin
are
derived
from
well-established
silkworm
production
constitute
a
biocompatible
biodegradable
protein
platform
development
drug
delivery
systems.
therapeutic
compounds
not
only
ensures
optimal
bioavailability
but
also
addresses
challenges
associated
with
conventional
methods.
multifaceted
benefits
silk
proteins,
including
their
inherent
biocompatibility,
versatility,
sustainability,
explored
this
review.
Furthermore,
intricate
mechanisms
by
which
takes
place
carriers
discussed.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(2), P. 206 - 206
Published: Jan. 10, 2024
Degradable
polymers
(both
biomacromolecules
and
several
synthetic
polymers)
for
biomedical
applications
have
been
promising
very
much
in
the
recent
past
due
to
their
low
cost,
biocompatibility,
flexibility,
minimal
side
effects.
Here,
we
present
an
overview
with
updated
information
on
natural
degradable
where
a
brief
account
different
polysaccharides,
proteins,
viz.
polyesters/polyamino
acids/polyanhydrides/polyphosphazenes/polyurethanes
relevant
has
provided.
The
various
approaches
transformation
of
these
by
physical/chemical
means
cross-linking,
as
polyblends,
nanocomposites/hybrid
composites,
interpenetrating
complexes,
interpolymer/polyion
functionalization,
polymer
conjugates,
block
graft
copolymers,
are
described.
degradation
mechanism,
drug
loading
profiles,
toxicological
aspects
polymeric
nanoparticles
formed
also
defined.
Biomedical
polymer-based
biomaterials
wound
dressing/healing,
biosensors,
delivery
systems,
tissue
engineering,
regenerative
medicine,
etc.,
highlighted.
In
addition,
use
such
nano
systems
solve
current
problems
is
briefly
reviewed.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
352, P. 122899 - 122899
Published: July 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(24)
Published: March 6, 2024
Abstract
The
quest
for
effective
and
reliable
methods
of
delivering
medications,
with
the
aim
improving
delivery
therapeutic
agent
to
intended
location,
has
presented
a
demanding
yet
captivating
field
in
biomedical
research.
concept
smart
drug
systems
is
an
evolving
approach,
serving
as
model
directing
drugs
specific
targets
or
sites.
These
have
been
developed
specifically
target
regulate
administration
substances
diverse
array
chronic
conditions,
including
periodontitis,
diabetes,
cardiac
diseases,
inflammatory
bowel
rheumatoid
arthritis,
different
cancers.
Nevertheless,
numerous
comprehensive
clinical
trials
are
still
required
ascertain
both
immediate
enduring
impacts
such
nanosystems
on
human
subjects.
This
review
delves
into
benefits
vehicles,
aiming
enhance
comprehension
their
applicability
addressing
present
medical
requirements.
Additionally,
it
touches
upon
current
applications
these
stimuli‐reactive
biomedicine
outlines
future
development
prospects.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(3), P. 739 - 739
Published: Feb. 5, 2024
Hyaluronan
(HA)
is
a
non-sulfated
glycosaminoglycan
that
present
in
variety
of
body
tissues
and
organs.
has
wide
range
biological
activities
are
frequently
influenced
by
molar
mass;
however,
they
also
depend
greatly
on
the
source,
purity,
kind
impurities
hyaluronan.
High-molar-mass
HA
anti-inflammatory,
immunosuppressive,
antiangiogenic
properties,
while
low-molar-mass
opposite
properties.
A
number
chemical
modifications
have
been
performed
to
enhance
stability
its
applications
medical
practice.
widely
applied
medicine,
such
as
viscosupplementation,
ophthalmology,
otolaryngology,
wound
healing,
cosmetics,
drug
delivery.
In
this
review,
we
summarized
several
polymers
based
hyaluronan
backbone.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 786 - 786
Published: Jan. 8, 2024
Studies
on
bionanocomposite
drug
carriers
are
a
key
area
in
the
field
of
active
substance
delivery,
introducing
innovative
approaches
to
improve
therapy.
Such
play
crucial
role
enhancing
bioavailability
substances,
affecting
therapy
efficiency
and
precision.
The
targeted
delivery
drugs
sites
action
minimization
toxicity
body
is
becoming
possible
through
use
these
advanced
carriers.
Recent
research
has
focused
structures
based
biopolymers,
including
lipids,
polysaccharides,
proteins.
This
review
paper
description
lipid-containing
nanocomposite
(including
liposomes,
lipid
emulsions,
nanoparticles,
solid
nanostructured
carriers),
polysaccharide-containing
alginate
cellulose),
protein-containing
(e.g.,
gelatin
albumin).
It
was
demonstrated
many
investigations
that
such
show
ability
load
therapeutic
substances
efficiently
precisely
control
release.
They
also
desirable
biocompatibility,
which
promising
sign
for
their
potential
application
development
indicates
novel
approach
improving
processes,
contribute
significant
advances
pharmacology,
efficacy
while
minimizing
side
effects.
Drug Discovery Today,
Journal Year:
2024,
Volume and Issue:
29(4), P. 103936 - 103936
Published: Feb. 29, 2024
This
review
highlights
the
transformative
impact
of
microfluidic
technology
on
personalized
drug
delivery.
Microfluidics
addresses
issues
in
traditional
synthesis,
providing
precise
control
and
scalability
nanoparticle
fabrication,
platforms
show
high
potential
for
versatility,
offering
patient-specific
dosing
real-time
monitoring
capabilities,
all
integrated
into
wearable
technology.
Covalent
conjugation
antibodies
to
nanoparticles
improves
bioactivity,
driving
innovations
targeting.
The
integration
microfluidics
with
sensor
technologies
artificial
intelligence
facilitates
feedback
autonomous
adaptation
delivery
systems.
Key
challenges,
such
as
droplet
polydispersity
fluidic
handling,
along
future
directions
focusing
reliability,
are
essential
considerations
advancing
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(41), P. 30201 - 30229
Published: Jan. 1, 2024
Recently,
metal-organic
frameworks
(MOFs)
have
attracted
much
attention
as
versatile
materials
for
drug
delivery
and
personalized
medicine.
MOFs
are
porous
structures
made
up
of
metal
ions
coupled
with
organic
ligands.
This
review
highlights
the
synthesis
techniques
used
to
design
specific
features
such
surface
area
pore
size,
encapsulation
within
not
only
improves
their
stability
solubility
but
also
allows
controlled
release
kinetics,
which
therapeutic
efficacy
minimizes
adverse
effects.
Furthermore,
it
discusses
challenges
potential
advantages
MOF-based
delivery,
MOF
stability,
biocompatibility,
scale-up
production.
With
further
advancements
in
synthesis,
functionalization
techniques,
understanding
interactions
using
biological
systems,
can
significant
promise
expanding
medicine
improving
patient
outcomes.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1076 - 1076
Published: Aug. 16, 2024
Preclinical
and
clinical
studies
have
demonstrated
that
precision
therapy
has
a
broad
variety
of
treatment
applications,
making
it
an
interesting
research
topic
with
exciting
potential
in
numerous
sectors.
However,
major
obstacles,
such
as
inefficient
unsafe
delivery
systems
severe
side
effects,
impeded
the
widespread
use
medicine.
The
purpose
drug
(DDSs)
is
to
regulate
time
place
release
action.
They
aid
enhancing
equilibrium
between
medicinal
efficacy
on
target
hazardous
effects
off
target.
One
promising
approach
biomaterial-assisted
biotherapy,
which
takes
advantage
biomaterials’
special
capabilities,
high
biocompatibility
bioactive
characteristics.
When
administered
via
different
routes,
molecules
deal
biological
barriers;
DDSs
help
them
overcome
these
hurdles.
With
their
adaptable
features
ample
packing
capacity,
biomaterial-based
allow
for
targeted,
localised,
prolonged
medications.
Additionally,
they
are
being
investigated
more
controlling
interface
host
tissue
implanted
biomedical
materials.
This
review
discusses
innovative
nanoparticle
designs
non-personalised
applications
improve
therapies.
We
prioritised
design
trends
address
heterogeneous
barriers,
because
we
believe
intelligent
can
patient
outcomes
by
enabling
improving
general
efficacy.
additionally
reviewed
most
recent
literature
biomaterials
used
biotherapy
vaccine
development,
covering
delivery,
stem
cell
therapy,
gene
other
similar
fields;
also
addressed
difficulties
future
biotherapies.
