Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease

Bioengineering, Journal Year: 2024, Volume and Issue: 11(3), P. 218 - 218

Published: Feb. 25, 2024

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In particular, patients who suffer from ischemic heart (IHD) that is not amenable to surgical or percutaneous revascularization techniques have limited treatment options. Furthermore, after successfully implemented, there are a number pathophysiological changes myocardium, including but ischemia-reperfusion injury, necrosis, altered inflammation, tissue remodeling, and dyskinetic wall motion. Electrospinning, nanofiber scaffold fabrication technique, has recently emerged as an attractive option potential therapeutic platform for cardiovascular disease. Electrospun scaffolds made biocompatible materials ability mimic native extracellular matrix compatible with drug delivery. These inherent properties, combined ease customization low cost production, electrospun active area research this review, we aim discuss current state electrospinning fundamentals creation role both bioengineered matrices delivery vehicles in CVD, special emphasis on clinical applications myocardial ischemia.

Language: Английский

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Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29783 - e29783

Published: April 17, 2024

Language: Английский

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Novel drug delivery systems: Insight into self-powered and nano-enabled drug delivery systems

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100042 - 100042

Published: July 11, 2024

Novel drug delivery systems comprise sophisticated technology merged into systems. These are created with the aim of addressing limitations conventional For instance, inefficient in tackling challenging human diseases such as cancer. thus formed materials to enhance permeation target cells. They improve patients' compliance and efficacy. include self-powered microelectromechanical Nanotechnology is a rapidly growing promising field, especially system development disease therapy. often utilise nanocarriers due their numerous advantages. One benefits ability manipulate size surface functionalisation achieve site-specific targeting. Many researchers have reported controlled targeted release profiles. Nanocarriers propelled tissues, where entrapped drugs released, prolonging therapeutic efficacy decreasing undesired side effects. Hence, these offer delivery, low toxicity, high bioavailability improved efficiency. It essential understand mechanisms toxicity order develop efficient safe This review describes utilisation novel also dwells on loading, targeting from nanocarriers. The primary concerns clinical applications potential presented. expected that this will be helpful formulation seeking solutions cancer cardiovascular diseases.

Language: Английский

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A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 670 - 670

Published: May 16, 2024

In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These offer promising strategies for targeted and controlled drug while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, healthcare landscape is constantly evolving, necessitating continual development innovative therapeutic approaches (DDSs). DDSs play a pivotal role enhancing treatment efficacy, minimizing adverse effects, optimizing patient compliance. Among these, nanotechnology-driven garnered due to their unique properties, such as improved solubility, release, delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., versatile platforms tissue engineering applications. Additionally, hold immense promise, leveraging natural or synthetic biopolymers encapsulate drugs enable release. numerous advantages, biocompatibility, biodegradability, low immunogenicity. The utilization polysaccharides, polynucleotides, proteins, polyesters biopolymer matrices further enhances versatility applicability DDSs. Moreover, substances emerged key players combating diseases, offering protection against cellular damage chronic illnesses. nanoformulations represents burgeoning research area, substantial increase publications years. This review provides comprehensive overview developments within this area over past five It discusses various materials, fabrication techniques, stabilizers, factors influencing degradation, it highlights emerging trends, challenges, prospects rapidly evolving field.

Language: Английский

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Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3133 - 3133

Published: March 8, 2024

The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems promoting controlled release pharmaceuticals bioactive agents context regeneration. Silk fibroin sericin are derived from well-established silkworm production constitute a biocompatible biodegradable protein platform development drug delivery systems. therapeutic compounds not only ensures optimal bioavailability but also addresses challenges associated with conventional methods. multifaceted benefits silk proteins, including their inherent biocompatibility, versatility, sustainability, explored this review. Furthermore, intricate mechanisms by which takes place carriers discussed.

Language: Английский

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