Journal of Ionic Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 100112 - 100112
Published: Sept. 1, 2024
Language: Английский
Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126955 - 126955
Published: Jan. 1, 2025
Language: Английский
Citations
2
Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(17), P. 14807 - 14819
Published: Aug. 26, 2024
Deep eutectic solvents (DES) are environmentally friendly with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized meet unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance various therapeutic needs, providing reliable approach opening door for creation cutting-edge drug formulations by resolving solubility issues pharmaceutics. This study outlines newly developing approaches solve problem inefficient API extraction due poor solubility. These emerging strategies also have capacity alter chemical and physical stability API, which triggers drug's shelf life possible health benefits. It is anticipated highlighted methods processes will developed capitalize on improve delivery sector.
Language: Английский
Citations
12
JACS Au, Journal Year: 2024, Volume and Issue: 4(10), P. 3744 - 3758
Published: Oct. 3, 2024
Eutectogels, a rising category of soft materials, have recently garnered significant attention owing to their remarkable potential in various domains. This innovative class materials consists eutectic solvent immobilized three-dimensional network structure. The use eco-friendly and cost-effective solvents further emphasizes the appeal these multiple applications. Eutectogels exhibit key characteristics most solvents, including environmental friendliness, facile preparation, low vapor pressure, good ionic conductivity. Moreover, they can be tailored display functionalities such as self-healing capability, adhesiveness, antibacterial properties, which are facilitated by incorporating specific combinations mixture constituents. perspective article delves into current landscape challenges associated with eutectogels, particularly focusing on applications CO
Language: Английский
Citations
6
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125279 - 125279
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127510 - 127510
Published: April 1, 2025
Language: Английский
Citations
0
Crystals, Journal Year: 2025, Volume and Issue: 15(4), P. 350 - 350
Published: April 9, 2025
In the pharmaceutical industry, deep eutectic solvents can be used to enhance solubility, permeability, and absorption of active ingredients. this paper, were prepared by combining ingredient fosamprenavir calcium with lactic acid in certain molar ratios. The aim study was create a therapeutic solvent same effect as ingredient, but enhanced properties. 1H NMR FTIR spectroscopy identify characterize chemical composition structural changes THEDES. Maximum release from solvent, permeability tested. Different mathematical models chosen describe kinetic behavior drug release.
Language: Английский
Citations
0
Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(8)
Published: July 14, 2024
Abstract The design of biologic and synthetic drugs in the pharmaceutical industry is facing three key challenges, namely, ensuring bioavailability, solubility, stability. Ionic liquids (ILs) deep eutectic solvents (DESs), classified as designer solvents, have emerged excellent for improving permeability stability biotherapeutic drugs. Moreover, they shown remarkable solubilizing effects drugs, particularly active ingredients (API), are known eco‐friendly solvents. Thus, this review, development formulations industries reported, underlying strategies designing most efficient both biotherapeutics examined.
Language: Английский
Citations
3
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1316 - 1316
Published: Oct. 2, 2024
Objectives: The study explores the potential of various deep eutectic solvents (DESs) to serve as drug delivery systems and pharmaceutical excipients. research focuses on two primary objectives: evaluating ability selected DES enhance solubility poorly water-soluble model drugs (IBU MFA), their physicochemical properties, including density, viscosity, flow behavior, surface tension, thermal stability, water dilution effects, determine suitability for applications. Methods: A range containing pharmaceutically acceptable constituents was explored, encompassing organic acid-based, sugar- sugar alcohol-based, hydrophobic systems, well menthol (MNT)-based with common MNT-based DESs exhibited most significant enhancements. Results: IBU reached 379.69 mg/g in MNT: PEG 400 (1:1) 356.3 MNT:oleic acid (1:1), while MFA peaked at 17.07 MNT:Miglyol 812®N (1:1). In contrast, hydrophilic significantly lower, choline chloride: glycerol (1:2) arginine: glycolic (1:8) showing best results. While demonstrating lower compared sugar-based increased tunability via addition both terms such viscosity tension. Conclusions: Our introduces novel expanding repertoire formulations opening new avenues rational design tailored solvent overcome challenges delivery.
Language: Английский
Citations
3
Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16
Published: Oct. 25, 2024
Deep eutectic solvents (DESs) are green alternatives to ionic liquids with wide applications in organic synthesis and catalysis. DESs characterized by being easily prepared, biodegradable, non-toxic non-inflammable. When one or more of the DES components is active pharmaceutical ingredient (API), they named as therapeutic deep (THEDESs). THEDESs prepared order improve solubility and/or permeability APIs. This review presents a brief summary most important reported date having antimicrobial anticancer activities. The challenges limitations THEDES preparation were also discussed. work presented here indicated importance promising drug delivery system that can overcome bioavailability problems while retaining enhancing biological activity its components.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Nov. 15, 2024
Therapeutic deep eutectic solvents (THEDES) are a type of eutectics that can be used as active pharmaceutical ingredients (APIs) by enhancing the drug bioavailability, increasing solubility APIs in aqueous solutions or their permeability through biological barriers. In this study, we demonstrate utility designer THEDES, based on Quillaja Saponin (SAP), triterpene natural product to unravel antimicrobial potential such THEDES. THEDES were prepared gently mixing and heating five different α- hydroxy acids- malic, citric, tartaric, glycolic, lactic acids SAP with water third component The assays performed as-prepared SAP-THEDES among panel bacterial strains, saponin-malic acid [SMA-THEDES] displayed potent activity disassembling PA biofilms, demonstrating SMA-THEDES serve therapeutic antibacterial biomaterials. To further optimize, Box-Behnken- response surface methodology (RSM) experimental design was done at optimum conditions (1.014 m.mol), Malic (1.003 Water (0.117 exhibited maximum MIC P. aeruginosa minimum absorbance 590 nm 0.105. effectiveness antibiofilm agents mechanism studies have been explored. colony count from vivo infection zebrafish model treatment group showed decline > 2 fold for SMA-THEDES. Toxicity did not reveal any abnormality liver brain enzyme levels. Liver morphology images show no severe cytological alterations when treated almost similar normal liver.
Language: Английский
Citations
1