3D printing metal implants in orthopedic surgery: Methods, applications and future prospects

Journal of Orthopaedic Translation, Journal Year: 2023, Volume and Issue: 42, P. 94 - 112

Published: Sept. 1, 2023

Currently, metal implants are widely used in orthopedic surgeries, including fracture fixation, spinal fusion, joint replacement, and bone tumor defect repair. However, conventional difficult to be customized according the recipient's skeletal anatomy characteristics, leading difficulties meeting individual needs of patients. Additive manufacturing (AM) or three-dimensional (3D) printing technology, an advanced digital fabrication technique capable producing components with complex precise structures, offers opportunities for personalization. We systematically reviewed literature on 3D over past 10 years. Relevant animal, cellular, clinical studies were searched PubMed Web Science. In this paper, we introduce method characteristics biometals summarize properties their applications surgery. On basis, discuss potential possibilities further generalization improvement. technology has facilitated use different procedures. By combining medical images from techniques such as CT MRI, allows based injured tissue. Such patient-specific not only reduce excessive mechanical strength eliminate stress-shielding effects, but also improve biocompatibility functionality, increase cell nutrient permeability, promote angiogenesis growth. addition, advantages low cost, fast cycles, high reproducibility, which can shorten patients' surgery hospitalization time. Many trials have been conducted using implants. modeling software, operation equipment, demand implant materials, lack guidance relevant laws regulations limited its application. There personalization, promotion osseointegration, short production cycle, material utilization. With continuous learning software by surgeons, improvement development materials that better meet needs, regulations, applied more surgeries. Precision, intelligence, personalization future direction orthopedics. It is reasonable believe will deeply integrated artificial 4D printing, big data play a greater role eventually become important part economy. aim latest developments engineers surgeons design closely mimic morphology function native bone.

Language: Английский

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3D printing in personalized medicine

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 101 - 126

Published: Jan. 1, 2025

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Advancements in 3D Printing Technologies for Personalized Treatment of Osteonecrosis of the Femoral Head

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101531 - 101531

Published: Feb. 5, 2025

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.

Language: Английский

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Assessing the compressive and tensile properties of TPMS-Gyroid and stochastic Ti64 lattice structures: A study on laser powder bed fusion manufacturing for biomedical implants

Journal of Science Advanced Materials and Devices, Journal Year: 2023, Volume and Issue: 9(1), P. 100663 - 100663

Published: Dec. 13, 2023

In the field of additive manufacturing, design and fabrication lattice structures have garnered substantial attention, particularly for their potential in advanced material applications. This study focuses on mechanical properties titanium alloy Ti64 fabricated by Laser Powder Bed Fusion. It examines features two structure types, TPMS Gyroid Stochastic Voronoi, analyzing interplay. To evaluate properties, methodologies to compute stress were employed: Method A, nominal diameter calculations cross-sectional area as a bulk material, B, averaged measurements along open-cell porous structures. A generally showed lower Elastic Modulus Yield Stress than highlighting importance geometric accuracy mechanics. Both gyroid stochastic lattices, within 0.1–0.5 relative density range, displayed similar human bone, suggesting orthopedic use. could help reduce shielding improve implant lifespan. The findings further complemented Scanning Electron Microscopy Digital Image Correlation evaluations, intricate relationship between parameters, morphology, emergent microstructural characteristics.

Language: Английский

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Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(10), P. 497 - 497

Published: Oct. 8, 2023

Within the human body, intricate network of blood vessels plays a pivotal role in transporting nutrients and oxygen maintaining homeostasis. Bioprinting is an innovative technology with potential to revolutionize this field by constructing complex multicellular structures. This technique offers advantage depositing individual cells, growth factors, biochemical signals, thereby facilitating functional vessels. Despite challenges fabricating vascularized constructs, bioprinting has emerged as advance organ engineering. The continuous evolution biomaterial knowledge provides avenue overcome hurdles associated tissue fabrication. article overview biofabrication process used create vascular constructs. It delves into various techniques engineering, including extrusion-, droplet-, laser-based methods. Integrating these prospect crafting artificial remarkable precision functionality. Therefore, impact engineering significant. With technological advances, it holds promise revolutionizing transplantation, regenerative medicine. By mimicking natural complexity vessels, brings us one step closer organs vasculature, ushering new era medical advancement.

Language: Английский

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Performance of textured dual mobility total hip prosthesis with a concave dimple during Muslim prayer movements

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 9, 2024

Abstract The single mobility bearing as a previous design of total hip prosthesis has severe constraints that can result in dislocation during Muslim (people who follow the Islam religion) prayer movements, specifically shalat requires intense movement. There are five movements (i.e., bowing, prostration, sitting, transition from standing to and final sitting) may generate an impingement problem for patients with prosthesis. In this work, textured dual two cases femoral head inner liner) presented their performances numerically evaluated against untextured surface model concave dimple is chosen texturing, while simulating materials, SS 316L CoCrMo choosen. To represent real condition, three-dimensional computational fluid dynamics (CFD) coupled two-way fluid–structure interaction (FSI) methods employed analyze elastohydrodynamic lubrication non-Newtonian synovial model. main aim present study investigate tribological performance on applied liner under movements. It found applying texturing beneficial effect some performs better than (both liner). numerical results also indicate superior compared head. These findings be used reference biomedical engineers orthopedic surgeons designing choosing suitable Muslims makes they carry out like humans general have normal joints.

Language: Английский

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3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

Exploration of Medicine, Journal Year: 2024, Volume and Issue: 5(1), P. 17 - 47

Published: Feb. 6, 2024

Three-dimensional (3D) and four-dimensional (4D) printing have emerged as the next-generation fabrication technologies, covering a broad spectrum of areas, including construction, medicine, transportation, textiles. 3D printing, also known additive manufacturing (AM), allows complex structures with high precision via layer-by-layer addition various materials. On other hand, 4D technology enables smart materials that can alter their shape, properties, functions upon stimulus, such solvent, radiation, heat, pH, magnetism, current, pressure, relative humidity (RH). Myriad biomedical (BMMs) currently serve in many engineering fields aiding patients’ needs expanding life-span. BMMs provides geometries are impossible conventional processing techniques, while yields dynamic BMMs, which intended to be long-term contact biological systems owing time-dependent stimuli responsiveness. This review comprehensively covers most recent technological advances towards fabricating for tissue engineering, drug delivery, surgical diagnostic tools, implants prosthetics. In addition, challenges gaps printed along future outlook, extensively discussed. The current addresses scarcity literature on composition, performances medical applications pros cons. Moreover, content presented would immensely beneficial material scientists, chemists, engineers engaged AM clinicians field. Graphical abstract.

Language: Английский

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Powder Bed Fusion 3D Printing in Precision Manufacturing for Biomedical Applications: A Comprehensive Review

Materials, Journal Year: 2024, Volume and Issue: 17(3), P. 769 - 769

Published: Feb. 5, 2024

Precision manufacturing requirements are the key to ensuring quality and reliability of biomedical implants. The powder bed fusion (PBF) technique offers a promising solution, enabling creation complex, patient-specific implants with high degree precision. This technology is revolutionizing industry, paving way for new era personalized medicine. review explores details 3D printing its application in field. It begins an introduction 3D-printing various classifications. Later, it analyzes numerous fields which has been successfully deployed where precision components required, including fabrication scaffolds tissue engineering. also discusses potential advantages limitations using terms precision, customization, cost effectiveness. In addition, highlights current challenges prospects technology. work valuable insights researchers engaged field, aiming contribute advancement context applications.

Language: Английский

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Quasi-static and fatigue performance of Ti-6Al-4V triply periodic minimal surface scaffolds manufactured via laser powder bed fusion for hard-tissue engineering

Results in Engineering, Journal Year: 2024, Volume and Issue: 24, P. 103101 - 103101

Published: Oct. 10, 2024

Language: Английский

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Revolutionising orthopaedic implants—a comprehensive review on metal 3D printing with materials, design strategies, manufacturing technologies, and post-process machining advancements

The International Journal of Advanced Manufacturing Technology, Journal Year: 2024, Volume and Issue: 134(3-4), P. 1043 - 1076

Published: Aug. 8, 2024

Abstract This paper conceptualises an understanding of advanced manufacturing methods to develop 3D-printed metallic orthopaedic implants, including a brief discussion on post-process machining. The significance Metallic Additive Manufacturing (MAM) and its practicality for industrial applications is discussed through juxtaposition with conventional casting machining approach. Different alloys suitable MAM techniques are thoroughly reviewed determine optimum operating conditions. Although can produce near-net shape parts, post-processing unavoidable requirement improve surface quality dimensional accuracy. A comparative study presented, highlighting the importance in terms cost savings performance. materials evaluated aiming overcome problems associated existing implants. consequence bone-implant mechanical mismatch leading stress shielding inadequate corrosion properties obstructing biodegradability explored detail. effect additive parameters mechanical, corrosion, biocompatibility analysed. Evidence MAM’s advantages over approaches, such as use functionally graded lattices patient-specific customised designs, also presented. Finally, future studies, two-way approach conceptualised material selection process control progressions implant development using MAM. Graphical

Language: Английский

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