Bioengineering, Journal Year: 2024, Volume and Issue: 11(7), P. 705 - 705
Published: July 11, 2024
Poly(lactic acid) (PLA) is widely used in the field of medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing or systematic deposition PLA layers has enabled fabrication customized scaffolds for various biomedical clinical applications. In tissue engineering regenerative medicine, 3D-printed been mostly generate bone scaffolds, typically combination with different polymers ceramics. PLA’s versatility also allowed development drug-eluting constructs controlled release agents, such as antibiotics, antivirals, anti-hypertensives, chemotherapeutics, hormones, vitamins. Additionally, recently develop diagnostic electrodes, prostheses, orthoses, surgical instruments, radiotherapy devices. provided a cost-effective, accessible, safer means improving patient care through dosimetry guides, well enhancing medical education training models simulators. Overall, widespread use settings expected persistently stimulate innovation revolutionize healthcare delivery.
Language: Английский
Citations
14Exploring the Potentials of Chitin and Chitosan‐Based Bioinks for 3D‐Printing of Flexible Electronics: The Future of Sustainable Bioelectronics
Small Methods, Journal Year: 2024, Volume and Issue: 8(9)
Published: Feb. 25, 2024
Chitin and chitosan-based bioink for 3D-printed flexible electronics have tremendous potential innovation in healthcare, agriculture, the environment, industry. This biomaterial is suitable 3D printing because it highly stretchable, super-flexible, affordable, ultrathin, lightweight. Owing to its ease of use, on-demand manufacturing, accurate regulated deposition, versatility with soft functional materials, has revolutionized free-form construction end-user customization. study examined employing chitin bioinks build electronic devices optimize formulation, parameters, postprocessing processes improve mechanical electrical properties. The exploration bioelectronics will open new avenues materials numerous industrial applications.
Language: Английский
Citations
9Computational Fluid Dynamics (CFD) Analysis of Bioprinting
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)
Published: April 22, 2024
Regenerative medicine has evolved with the rise of tissue engineering due to advancements in healthcare and technology. In recent years, bioprinting been an upcoming approach traditional practices, through fabrication functional by its layer-by-layer deposition process. This overcomes challenges such as irregular cell distribution limited density, it can potentially address organ shortages, increasing transplant options. Bioprinting fully organs is a long stretch but advancement rapidly growing precision compatibility complex geometries. Computational Fluid Dynamics (CFD), carestone computer-aided engineering, instrumental assisting research development cutting costs saving time. CFD optimizes testing parameters shear stress, diffusivity, viability, reducing repetitive experiments aiding material selection bioprinter nozzle design. review discusses current application potential enhance technology that contribute evolution regenerative medicine.
Language: Английский
Citations
7Revolutionizing drug delivery: Exploring the impact of advanced 3D printing technologies on polymer-based systems
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105839 - 105839
Published: June 5, 2024
Language: Английский
Citations
7Silver Nanoparticles in 3D Printing: A New Frontier in Wound Healing
ACS Omega, Journal Year: 2024, Volume and Issue: 9(40), P. 41107 - 41129
Published: Sept. 16, 2024
This review examines the convergence of silver nanoparticles (AgNPs), three-dimensional (3D) printing, and wound healing, focusing on significant advancements in these fields. We explore unique properties AgNPs, notably their strong antibacterial efficacy potential applications enhancing recovery. Furthermore, delves into 3D printing technology, discussing its core principles, various materials employed, recent innovations. The integration AgNPs 3D-printed structures for regenerative medicine is analyzed, emphasizing benefits this combined approach identifying challenges that must be addressed. comprehensive overview aims to elucidate current state field direct future research toward developing more effective solutions healing.
Language: Английский
Citations
6Engineering of brewery waste-derived graphene quantum dots with ZnO nanoparticles for treating multi-drug resistant bacterial infections
Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112263 - 112263
Published: Feb. 20, 2024
Language: Английский
Citations
4Enhancing anti-fouling and anti-clotting properties of UV Curable 3D printed polyurethane derivative resins with heparin for artificial blood vessels
Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2025, Volume and Issue: 168, P. 105933 - 105933
Published: Jan. 5, 2025
Language: Английский
Citations
0Highly Elastic, Biodegradable Polyester-Based Citrate Rubber for 3D Printing in Regenerative Engineering
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Highly elastic and 3D-printable degradable elastomers are advantageous for many biomedical applications. Herein, we report the synthesis of a biodegradable citrate rubber poly(tetrahydrofuran-co-citrate-co-hydroxyl telechelic natural rubber) (PTCR) using citric acid, poly(tetrahydrofuran), hydroxyl rubber. The PTCR is methacrylated to synthesize prepolymer methacrylated-PTCR (mPTCR) that can be used fabricate bioresorbable scaffolds via 3D printing micro-continuous liquid interface production. Polymers were chemically characterized NMR spectroscopy, FTIR DSC, TGA mechanically tensile testing crimping. addition improved elasticity (658 ± 68% dry 415 45% swollen films) significantly compared with its nonrubber-based copolymer, i.e., poly(tetrahydrofuran-co-citrate) (PTC) (550 51% 88 10% films). Also, mechanical strength reached as high 0.8 0.06 MPa after successful into PTC, which had 0.55 0.04 MPa. Notably, 3D-printed vascular scaffold mPTCR demonstrated excellent competence in crimping expansion, necessary clinical use. percent diameter recovery (89.4 1.1%) was higher than nonrubber version, methacrylated-poly(tetrahydrofuran-co-citrate) (mPTC) (77.2 6.7%), illustrating contribution mPTCR. In vitro degradation studies showed rapid hydrolytic elastomer 6 weeks, whereas degraded slowly due stability methacrylation. cytocompatibility cell attachment on surfaces successfully by L929 mouse myoblasts. To conclude, this study reports citrate-based should help meet some requirements tissue-engineering
Language: Английский
Citations
0Cutaneous Evaluation of Fe3O4 Nanoparticles: An Assessment Based on 2D and 3D Human Epidermis Models Under Standard and UV Conditions
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3653 - 3670
Published: March 1, 2025
The high-speed development of nanotechnology industry has fueled a plethora engineered nanoparticles (NPs) and NP-based consumer products, further leading to massive uncontrolled human exposure. In this regard, the researches addressing safety assessment NPs should be re-approached from perspective test parameters variety, closely simulating daily life scenarios. Therefore, present study adopts complex in vitro models establish profile Fe3O4 NPs, by using 2D 3D epidermis under both standard UV exposure conditions. Advanced reconstructed epidermal tissues two different monolayers immortalized cells (keratinocytes fibroblasts), series assays were employed current evaluate multiple biological responses, as follows: i) divers protocols (skin irritation, phototoxicity assay); ii) conditions (± exposure) iii) wide variety quantification methods, such as: MTT, NR LDH colorimetric tests - performed viability cells/microtissues, respectively, cytotoxicity compounds. addition, IL-1α ELISA assay was used quantify inflammatory activity induced samples, while immunocytochemistry analysis through fluorescent microscopy provide insightful information regarding possible mechanism action samples. samples (S1 S2) higher cell decrease on keratinocytes (HaCaT) compared fibroblasts (1BR3), 3D-epidermis microtissues showed similar viabilities when treated with (-UV rays) for type evaluation protocols: skin irritation phototoxicity. However, irradiation 3D-microtissues pre-exposed led results between revealing that S2 sample significant impairment viability, whereas S1 elicited an one recorded (-UV). indicate differences toxicity conditions, highlighting importance model selection assessing NP safety. Thus, our findings suggest may pose some risks specific environmental within limitations experimental setup, research is needed refine guidelines.
Language: Английский
Citations
0Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries
Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)
Published: March 24, 2025
Abstract Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, inherent bioinert nature leads to high failure rates < 6 mm diameter applications due thrombotic complications mechanical mismatch with host tissue. Decellularized matrices (dECM) scaffolds emerge as biologically strategic alternative, preserving crucial basement membrane components biomechanical cues through collagen/elastin retention. The present review systematically elaborates research advancements, determinants, practical challenges utilizing dECM for tiny-diameter artificial vessels (inner 3 mm), while proposing three forward-looking solutions address clinical translation barriers: (1) matrix optimization strategies diameter-specific compliance matching elastin reconstitution; (2) sterilization preservation protocols structural integrity controlled immunogenicity; (3) immunomodulatory engineering via macrophage polarization regulation. proposed methodologies establish innovative avenues transplantation vessels. Graphical abstract
Language: Английский
Citations
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