Progress in cardiac tissue engineering and regeneration: Implications of gelatin-based hybrid scaffolds

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129924 - 129924

Published: Feb. 2, 2024

Language: Английский

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Recent Advances in Natural Fiber Reinforced Metal/Cement/Polymer Composites: An Overview of the Structure-Property Relationship for Engineering Applications.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100378 - 100378

Published: Jan. 1, 2025

Language: Английский

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Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 435 - 435

Published: Feb. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Language: Английский

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Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106681 - 106681

Published: Feb. 7, 2025

Language: Английский

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Synthesis, functionalization, and commercial application of cellulose-based nanomaterials: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134990 - 134990

Published: Aug. 23, 2024

Language: Английский

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Nanoparticles in Periodontitis Therapy: A Review of the Current Situation

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6857 - 6893

Published: July 1, 2024

Periodontitis is a disease of inflammation that affects the tissues supporting periodontium. It triggered by an immunological reaction gums to plaque, which leads destruction periodontal attachment structures. one most commonly recognized dental disorders in world and major factor loss adult teeth. Scaling root planing remain crucial for managing patients with persistent periodontitis. Nevertheless, exclusive reliance on mechanical interventions like surgery, extractions, planning insufficient halt progression In response problem bacterial resistance, some researchers are committed finding alternative therapies antibiotics. addition, scholars focus new materials provide powerful microenvironment tissue regeneration promote osteogenic repair. Nanoparticles possess distinct therapeutic qualities, including exceptional antibacterial, anti-inflammatory, antioxidant properties, immunomodulatory capacities, promotion bone ability, made them can be used treatment However, there many problems limit clinical translation nanoparticles, such as toxic accumulation cells, poor correlation between vitro vivo, animal-to-human transmissibility. this paper, we review present researches nanoparticles periodontitis from perspective three main categories: inorganic organic nanocomposites (including nanofibers, hydrogels, membranes). The aim comprehensive recent update nanoparticles-based conclusion section summarizes opportunities challenges design

Language: Английский

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Electrospun Chitosan/Polylactic Acid Nanofibers with Silver Nanoparticles: Structure, Antibacterial, and Cytotoxic Properties

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Electrospinning, a technique for creating fabric materials from polymer solutions, is widely used in various fields, including biomedicine. The unique properties of electrospun fibrous membranes, such as large surface area, compositional versatility, and customizable porous structure, make them ideal advanced biomedical applications like tissue engineering wound healing. By considering the high biocompatibility well-known regenerative potential polylactic acid (PLA) chitosan (CH), well versatile antibacterial effect silver nanoparticles (AgNPs), this study explores efficacy, adhesive properties, cytotoxicity membranes with nanofibrous structure varying concentrations AgNPs. Silver incorporated at 25-50 μg/mL or above significantly enhanced effectiveness, especially against Staphylococcus aureus Escherichia coli. Biocompatibility assessments using umbilical cord mesenchymal stem cells demonstrated nontoxic nature an AgNP concentration 12.5 μg/mL, underscoring their applications. This provides valuable insights into developing effective antimicrobial coatings uses, healing patches constructs soft replacement.

Language: Английский

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Cellulose-Based Nanofibers Infused with Biotherapeutics for Enhanced Wound-Healing Applications

ACS Polymers Au, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Nanofibers fabricated from various materials such as polymers, carbon, and semiconductors have been widely used for wound healing tissue engineering applications due to their excellent nontoxic, biocompatible, biodegradable properties. with a diameter in the nanometer range possess larger surface area per unit mass permitting easier addition of functionalities release biotherapeutics incorporated compared conventional polymeric microfibers. Henceforth, nanofibers are choice fabricating scaffolds management healing. Nanofibrous emerged promising method dressings since they mimic fibrous dermal extracellular matrix milieu that offers structural support functional signals guiding regeneration. Cellulose-based gained significant attention among researchers fabrication on-site fortified Cellulose is linear, stereoregular insoluble polymer built repeated units d-glucopyranose linked 1,4-β glycoside bonds complex multilevel supramolecular architecture. has by its solubility many solvents capacity self-assembly into nanofibers, facilitating mimicry natural architecture promoting substantial water retention. It also abundant demonstrates low immunogenicity humans nonanimal origins. To this end, cellulose-based studied protein delivery, antibacterial activity, biosensor applications, others. Taken together, review delves an update on fused bioactive compounds not explored considerably past few years.

Language: Английский

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A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141394 - 141394

Published: Feb. 1, 2025

Language: Английский

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Machine Learning Optimized FeCoMn‐Trimetallic MOF‐Decorated Nanofibers for Enhanced OER Catalysis

Advanced Sustainable Systems, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Despite significant advancements in noble metal‐free trimetallic MOF‐based electrocatalysts for efficient oxygen evolution reaction (OER), limited attention is given to identify which metal will play most role controlling OER performance. Thus, address this gap, herein ternary metallic (FeCoMn) squarate‐based MOF via a solvothermal approach synthesized. Additionally, machine learning (ML) algorithms are employed on experimental datasets during synthesis strategy optimize concentrations more swiftly and efficiently design highly squarate electrocatalysts. Interestingly, ML optimization has identified Fe as key element significantly influencing efficacy. To further boost efficacy, ML‐optimized FeCoMn drop‐casted onto conductive electrospun polycaprolactone (PC) nanofibers, facilitating smooth, uniform flow of ions electrons across the entire surface, maximizing exposed active sites, all anchored sponge‐like Ni foam (NF) substrate. Results reveal that FeCoMn/PC displays high electrocatalytic activity with lower overpotential (170 mV at current density 10 mA cm −2 ), Tafel slope 66.6.8 dec −1 , compared (overpotential 180 mV, 89.3 ). best knowledge, first time optimized FeCoMn/PC‐based electrocatalyst reported.

Language: Английский

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