Review of: "The Role of Ferroptosis in Inflammatory Bowel Disease: Mechanisms and Therapeutic Implications" DOI Creative Commons
Qiang Cao

Published: March 5, 2024

Mechanisms and Therapeutic Implications" is an exemplary piece of scientific literature, masterfully written deeply insightful.The comprehensive analysis eloquent presentation the complex mechanisms ferroptosis its implications in pathology Inflammatory Bowel Disease showcase author's profound understanding extensive research field.The meticulous detail, clear articulation, groundbreaking revelations provide invaluable contribution to medical science, particularly context gastrointestinal disorders.The integration current with thoughtful discussion on potential therapeutic targets brilliantly executed, reflecting cutting-edge developments cellular biology their applications improving patient outcomes.This article not only a testament expertise but also beacon knowledge for researchers, clinicians, academicians alike, paving way innovative treatments better IBD.It outstanding work that deserves highest praise widespread recognition significant impact community beyond.

Language: Английский

Inverted U-shaped relationship between sleep duration and phenotypic age in US adults: a population-based study DOI Creative Commons
Yanwei You, Yuquan Chen, Ruidong Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 15, 2024

Sleep is a modifiable behavior that can be targeted in interventions aimed at promoting healthy aging. This study aims to (i) identify the sleep duration trend US adults; (ii) investigate relationship between and phenotypic age; (iii) explore role of exercise this relationship. Phenotypic age as novel index was calculated according biomarkers collected from adults based on National Health Nutrition Examination Survey (NHANES). information self-reported by participants discerned through individual interviews. The principal analytical method employed weighted multivariable linear regression modeling, which accommodated for complex multi-stage sampling design. potential non-linear explored using restricted cubic spline (RCS) model. Furthermore, subgroup analyses evaluated effects sociodemographic lifestyle factors primary outcomes. A total 13,569 were finally included in, thereby resulting population 78,880,615. An examination temporal trends revealed declining proportion individuals with insufficient markedly deficient time since 2015-2016 cycle. Taken normal group reference, extreme short [β (95% CI) 0.582 (0.018, 1.146), p = 0.044] long 0.694 (0.186, 1.203), 0.010] both positively associated fully adjusted According dose-response age, benefit regular activity, whereas more tended have higher age. There an inverted U-shaped durations represents important step forward our understanding By shedding light topic providing practical recommendations habits, researchers help live longer, healthier, fulfilling lives.

Language: Английский

Citations

50
Association of the newly proposed dietary index for gut microbiota and depression: the mediation effect of phenotypic age and body mass index DOI
Xuan Zhang,

Qinglong Yang,

Jingtao Huang

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Language: Английский

Citations

17
Synergistic impact of 25-hydroxyvitamin D concentrations and physical activity on delaying aging DOI Creative Commons
Chang Liu,

Lin Hua,

Xin Zhong

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 73, P. 103188 - 103188

Published: May 10, 2024

Our study aims to examine the independent and combined associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations physical activity (PA) status with phenotypic age (PhenoAge). The analysis included 18,738 participants from NHANES 2007-2010 & 2015-2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as residuals regressing PhenoAge on chronological age. Weighted multivariable logistic regression models were used relationship between 25(OH)D PA PhenoAgeAccel. Population attributable fraction (PAF) estimate proportion PhenoAgeAccel which could be avoided if exposure eliminated. multivariate-adjusted OR (95%CI) for high adequate 0.657 (0.549,0.787) (p<0.001) all, 0.663 (0.538,0.818) whose ≤ 65years old. Furthermore, there multiplicative interaction in 65 years old group (0.729 (0.542,0.979), p = 0.036). High level reduced risk by 14.3% 14.2%, respectively. Notably, 30.7% decrease both engaging concurrently. Combining above 80.4 nmol/l decreased 1.291 (p<0.001). Higher associated lower biological ageing. demonstrated enhanced protective effects, especially middle or young adults. These findings underscore importance outdoor slowing down aging process.

Language: Английский

Citations

15
Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 DOI Creative Commons

Song Nguyen Tran Bao,

Weibu Jimu,

奈美 高木

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Muscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle index (ASMI) and phenotypic age(PhenoAge), while examining mediating of systemic inflammation. The analysis included 7,440 participants from NHANES 2011-2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as residuals regressing PhenoAge on chronological age. Multivariable linear regression analyses were performed assess ASMI PhenoAgeAccel. Mediation conducted quantify extent which inflammation contributes this association. Our revealed that higher is linked slower aging, evidenced by lower PhenoAgeAccel (β = -0.48, 95% CI: -0.66 -0.29, p 0.0001). Systemic partially mediated effect, with mediation proportion 35.1%. varied notably across demographic health-related subgroups, being particularly significant females, individuals obesity, those physical activity. These findings highlight critical importance slowing emerging key mediator. public implications are substantial, suggesting targeted interventions-such resistance training, anti-inflammatory diets, personalized medical approaches-could play decelerating improving long-term outcomes.

Language: Английский

Citations

1
Exploration of physical activity, sedentary behavior and insulin level among short sleepers DOI Creative Commons
Yuquan Chen, Yanwei You,

Mengxian Wei

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 14, 2024

Sufficient physical activity and sleep duration are essential for overall health. While one-third of the US population reports short (<7 h), which is proven to link with negative health status. Current evidence on relationship between activity, sedentary behavior, serum insulin level in groups limited.

Language: Английский

Citations

6
The effects of different types of Tai Chi exercise on anxiety and depression in older adults: a systematic review and network meta-analysis DOI Creative Commons

Xiaoqin Kuang,

Yangjian Dong,

Long Song

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 8, 2024

The body of evidence supporting the beneficial effects Tai Chi in reducing anxiety and depressive symptoms older adults is steadily increasing. Nonetheless, there remains a scarcity studies directly comparing clinical effectiveness various exercises addressing adults. Thus, this study aimed to systematically review analyze therapeutic efficacy four types interventions enhancing

Language: Английский

Citations

5
Unraveling the mechanisms of NK cell dysfunction in aging and Alzheimer’s disease: insights from GWAS and single-cell transcriptomics DOI Creative Commons
Jinwei Li, Yang Zhang, Yanwei You

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 23, 2024

Background Aging is an important factor in the development of Alzheimer’s disease (AD). The senescent cells can be recognized and removed by NK cells. However, cell function gradually inactivated with age. Therefore, this study used senescence as entry point to investigate how affect AD. Methods validated correlation between cognition aging through a prospective cohort National Health Nutrition Examination Survey database. A cellular trajectory analysis population was performed using single-cell nuclear transcriptome sequencing data from patients AD different ages. genome-wide association (GWAS) outcome event, expression quantitative trait locus instrumental variable. Causal associations genes were analyzed bidirectional Mendelian randomization (MR) co-localization. Finally, clinical cohorts constructed validate key genes. Results demonstrated 2,171 older adults over 60 years Gene regulation revealed that most highly active transcription factors concentrated subpopulation trajectories for age populations. MR co-localization analyses CHD6 may one influencing Conclusion We explored levels cohorts, data, GWAS found there some correlations It also provides basis potential causation.

Language: Английский

Citations

4
Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review DOI Creative Commons
Ya‐Ting Liang, Charlotte Wang, Chuhsing Kate Hsiao

et al.

Journal of Medical Internet Research, Journal Year: 2024, Volume and Issue: 26, P. e59497 - e59497

Published: Sept. 11, 2024

Background Monitoring free-living physical activity (PA) through wearable devices enables the real-time assessment of features associated with health outcomes and provision treatment recommendations adjustments. The conclusions studies on PA depend crucially reliable statistical analyses digital data. Data analytics, however, are challenging due to various metrics adopted for measuring PA, different aims studies, complex temporal variations within variables. application, interpretation, appropriateness these analytical tools have yet be summarized. Objective This research aimed review that used methods analyzing monitored by accelerometers. Specifically, this addressed three questions: (1) What describe an individual’s daily PA? (2) current data, particularly under classification, association outcomes, prediction events? (3) challenges exist in analyses, what future suggested regarding use tasks? Methods scoping was conducted following existing framework map exploring information about PA. Three databases, PubMed, IEEE Xplore, ACM Digital Library, were searched February 2024 identify related publications. Eligible articles association, or involving human Results After screening 1312 articles, 428 (32.62%) eligible identified categorized into at least 1 3 thematic categories: classification (75/428, 17.5%), (342/428, 79.9%), (32/428, 7.5%). Most (414/428, 96.7%) derived variables from 3D acceleration, rather than 1D acceleration. All (428/428, 100%) considered represented time domain, while a small fraction (16/428, 3.7%) also frequency domain. number evaluating influence conditions has increased greatly. Among our review, regression-type models most prevalent (373/428, 87.1%). machine learning approach is gaining popularity (32/75, 43%). In addition summary statistics several recent incorporate trajectories account patterns, including longitudinal data analysis repeated measurements functional as continuum time-varying (68/428, 15.9%). Conclusions Summary can quickly provide descriptions strength, frequency, duration individuals’ overall When distribution profile need evaluated detected, considering detailed improve understanding role plays health. Depending goal, appropriate ensure reliability scientific findings.

Language: Английский

Citations

4
Immune Alterations with Aging: Mechanisms and Intervention Strategies DOI Open Access

Weiru Yu,

Yifei Yu,

Siyuan Sun

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3830 - 3830

Published: Nov. 8, 2024

Aging is the result of a complex interplay physical, environmental, and social factors, leading to an increased prevalence chronic age-related diseases that burden health care systems. As global population ages, it crucial understand aged immune system, which undergoes declines in both innate adaptive immunity. This decline exacerbates aging process, creating feedback loop accelerates onset diseases, including infectious autoimmune disorders, cancer. Intervention strategies, dietary adjustments, pharmacological treatments, immunomodulatory therapies, represent promising approaches counteract immunosenescence. These interventions aim enhance function by improving activity interactions aging-affected cells, or modulating inflammatory responses through suppression excessive cytokine secretion pathway activation. Such strategies have potential restore homeostasis mitigate inflammation, thus reducing risk linked aging. In summary, this review provides insights into effects underlying mechanisms immunosenescence, as well its interventions, with particular emphasis on relationship between aging, immunity, nutritional factors.

Language: Английский

Citations

4
Development Trends in the Clinical Test of Multiple Myeloma from 2000 to 2023: A Bibliometric Study DOI Creative Commons
Hongcheng Wu,

Haomiao Sun,

Yichen Wang

et al.

Published: Jan. 9, 2025

Objective: This study investigates the development trends and research hotspots in clinical testing for multiple myeloma from 2000 to 2023, using bibliometric techniques. Method: Search relevant literature on of published Web Science Core Collection (WoSCC) use CiteSpace 6.2.R4 software draw a visual knowledge map authors, institutions, national regional cooperation networks, journals, keywords, conduct analysis. Results: The found an upward trend publications over specified period, with significant growth noted 2012 onwards. majority originates United States, contributions institutions like Mayo Clinic MD Anderson Cancer Center. Analysis author collaboration networks indicated relatively low centrality, suggesting minimal among researchers. Bibliometric mapping highlighted several field including therapeutic strategies involving proteasome inhibitors immunomodulatory drugs, role stem cell transplantation, importance achieving monitoring residual disease. Conclusion: is characterized by growing body research, States. Despite increasing volume there need enhanced researchers consolidate findings advance practice.

Language: Английский

Citations

0