Maternal exposure to polystyrene nanoplastics induces sex-specific kidney injury in offspring

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 293, P. 118006 - 118006

Published: March 1, 2025

Maternal exposure to polystyrene nanoplastics (PS-NPs) during pregnancy and lactation has been linked adverse effects on offspring kidney development, with sex-specific outcomes. This study investigated the impact of maternal PS-NPs weight, histology, transcriptomics, functional pathways in mice. Offspring exposed exhibited significantly lower body weight (P < 0.05) an increased kidney-to-body ratio 0.05), particularly males. Histological analysis revealed a reduction glomerular number PS-NP-treated groups. Transcriptome profiling identified 758 differentially expressed genes (DEGs) male 101 DEGs female offspring, males showing more pronounced alteration gene expression. KEGG pathway enrichment highlighted disruptions immune response, cell cycle regulation, metabolism, exhibiting extensive changes than females. Additionally, renal fibrosis molecular analyses confirming expression patterns apoptosis. Immunohistochemical enhanced macrophage infiltration cleaved caspase-3 expression, indicating heightened apoptotic responses Further investigation small molecules BI-D1870 Resatorvid as potential therapeutic agents, reducing fibrosis, inflammation, apoptosis respectively. These findings demonstrate that induces injury disrupting key biological processes pathways. The underscores need for targeted interventions mitigate these highlights compounds future treatment.

Language: Английский

---

Advances in plant essential oils and drug delivery systems for skincare

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Essential oils, often referred to as "liquid gold," are renowned for their broad biological activity. Ancient Egyptians used essential oils' antibacterial and antiseptic effects preserve mummies, ancient Greeks olive oil sun protection, Chinese oils treat wounds. When applied the facial skin, potent anti-inflammatory, antioxidant, pharmacological characteristics provide various benefits, including sunscreen, skin-whitening, anti-aging effects. This paper aims summarize application of plant in skin whitening, antioxidant recent years, deeply analyzes internal relationship between modern drug delivery system, expounds how overcome limitations through specific enhance its activity stability, realize sustained release reduce potential toxicity, also discusses positive on brain function olfactory pathway, emphasizes possible safety risks use oil, puts forward corresponding suggestions use. Using keywords such "essential oils," "antioxidant," "anti-tyrosinase," Antibacterial Effects anti-inflammatory," "anti-anxiety," "drug carrier systems," a comprehensive search was conducted PubMed, CNKI, Baidu, Wanfang databases articles from past 5 years. Further screening performed select studies demonstrating efficacy topical or external application. Various showed strong oxidants, agents, anti-inflammatory skin-whitening agents. Combined with new it not only enhances but reduces inherent defects volatility, irritation, has targeted effect. At same time, integration into care products can make dual functions smell epidermal system nourish repair maximize oil. review delves systems, advocating broader natural resources technology. By strategically utilizing we promote sustainable development global economy. However, extensive clinical trials still required evaluate effectiveness systems.

Language: Английский

---

Research on the Biological Potential of Lemon ( Citrus Limon L. Burm.) Peel Extracts as a Multi functional Cosmetic Raw Material

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

The study aimed to explore the potential of lemon peel extracts as a cosmetic raw material, with focus on their aromatic, antimicrobial and various biological activities. Lemon essential oil (PLEO), extract (PLE) absolute (PLAO) were prepared by steam distillation organic solvent extraction, respectively. compositions PLEO, PLE PLAO analyzed GC/MS, revealing 22, 39, 9 components respectively, terpenoids being main component. had highest total flavonoid content, surpassing that polyphenols. Aroma intensity, measured an electronic pen, followed order LPEO > LPE LPAO, while aroma persistence was ranked LPAO LPE. All three showed strong antibacterial (against E. coli, S. aureus, C.albicans), well antioxidant anti-tyrosinase properties, inhibition rates exceeding 90% in dose-dependent manner. demonstrated superior anti-inflammatory effects compared LPE, inhibitory 87.79 ± 3.86% 80.75 2.33% TNF-α IL-6 at concentration 1×10^{− 2} mg/mL. found promote HaCat cell migration, showing greater effectiveness than LPAO. healing rate scratched cells treated µL/mL for 12 hours 95.29 3.41%. In conclusion, combination these could broaden applications cosmetics offering aroma-enhancing, antioxidant, whitening, antibacterial, anti-inflammatory, skin wound benefits.

Language: Английский

---

Bioactive profiling of Rumex vesicarius L. from the Hail region of Saudi Arabia: a study on its phytochemical and elemental analysis, antibiofilm, antibacterial, antioxidant properties, and molecular docking analysis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 29, 2024

Rumex vesicarius is a wild leafy plant belonging to the family Polygonaceae, renowned for its therapeutic benefits. The genus comprises approximately 150 species distributed globally. study aimed investigate biological activities of R. using in vitro and silico methods. was collected from mountains Hail extracted with methanol. phytochemical composition qualitatively determined colorimetric detection Additional analyses included elemental analysis, docking, antioxidant, antibacterial, anti-biofilm properties. extract contained various classes phytochemicals, including flavonoids, phenolics, tannins, terpenes, saponins. Sixteen constituents were identified through molecular revealing inhibition against filamentous temperature-sensitive protein Z (FtsZ), crucial factor bacterial cell division. Six compounds exhibited low binding scores ranging -8.3 -5.0 kcal/mol, indicating efficient interaction at active site. Elemental analysis 15 elements, potassium being most abundant, followed by calcium, aluminum, silicon, iron, phosphorus, sulfur, magnesium, titanium, strontium, zinc, manganese, bromine, chromium. Antioxidant revealed significant properties lower concentrations compared ascorbic acid, butylated hydroxytoluene, β-carotene. Antibacterial demonstrated inhibitory effects on Bacillus subtilis MTCC121 Pseudomonas aeruginosa MTCC 741, zones 13.67 ± 1.0 mm 11.50 mm, respectively. MIC MBC values ranged 250 500 μg/mL. also activity. Wild-grown rich bioactive phytochemicals essential minerals, exhibiting notable antioxidant antibacterial

Language: Английский

---

Formulation of a Three-Component Essential Oil Mixture from Lavandula dentata, Rosmarinus officinalis, and Myrtus communis for Improved Antioxidant Activity

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1071 - 1071

Published: Aug. 15, 2024

The optimization of existing natural antioxidants that are highly effective is crucial for advancements in medicine and the food industry. Due to growing concerns regarding safety synthetic antioxidants, researchers increasingly focusing on sources, particularly essential oils (EOs). Combining EOs might enhance antioxidant activity due increased chemical diversity. This study investigates, first time, properties from Lavandula dentata, Rosmarinus officinalis, Myrtus communis, both individually combination, using augmented-simplex design methodology. vitro evaluation was performed DPPH ABTS radical scavenging assays. Chromatography gas-mass spectrometry (CG-MS) revealed 1,8-cineol (37.27%) pinocarveol (12.67%) primary components L. dentata; verbenone (16.90%), camphor (15.00%), camphene (11.03%) predominant R. officinalis; while cineol (43.32%) main component M. communis. showed varying activities against radicals, with assay values ranging 194.10 ± 3.01 541.19 3.72 µg/mL 134.07 1.70 663.42 2.99 µg/mL. These were enhanced when combined. optimal blend DPPHIC50 consisted 20% 50% 30% For highest activity, best combination 18% 43% 40% results highlight potential EO combinations as new formulations use cosmeceutical, food, pharmaceutical sectors.

Language: Английский

---

Optimization of bioactive compounds recovery from thuya solid residues using ultrasound and nonionic surfactants assisted extraction: A response surface methodology study

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 43, P. 101878 - 101878

Published: Dec. 7, 2024

Language: Английский

---

Chemical Composition and Assessment of the Anti-Inflammatory, Antioxidant, Cytotoxic and Skin Enzyme Inhibitory Activities of Citrus sinensis (L.) Osbeck Essential Oil and Its Major Compound Limonene

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1652 - 1652

Published: Dec. 8, 2024

Background/Objectives: Essential oils (EOs) from Citrus species have attracted attention for their diverse properties, including anti-inflammatory, antioxidant and cytotoxic effects, which address critical health challenges such as chronic diseases skin disorders. sinensis (L.) Osbeck, is a widely cultivated citrus fruit, attracting increasing in the field of medicinal research due to its richness limonene (comprising approximately 85–90% oil). This study investigates chemical profile CS-EO biological activities limonene. Methods Results: used gas chromatography–mass spectrometry (GC-MS), confirming predominant compound (70.15%) along with other minor constituents, thujene (10.52%), myrcene (5.54%) α-pinene (2.81%). The were examined, specifically focusing on antioxidant, cytotoxicity dermatoprotective effects. Antioxidant potential was evaluated using DPPH, FRAP beta-carotene assays, exhibiting comparable efficacy. Anti-inflammatory properties assessed via inhibition assays prostaglandin E2 (PGE2) nitric oxide (NO) production, showing significant reductions LPS-stimulated macrophages treated by or Cytotoxicity testing various cell lines indicated selective activity tested compounds, low toxicity observed human fibroblasts. Limonene highly effective HepG2 cellules, IC50 values 0.55 ± 0.01 µg/mL 15.97 1.20 µg/mL, respectively. Dermatoprotective effects further confirmed enzymes, where showed remarkable inhibitory against elastase (IC50 65.72 1.92 86.07 1.53 respectively) tyrosinase 102 2.16 78.34 1.15 enzymes compared quercetin standard 111.03 0.1 124.22 0.07 respectively). Conclusions: findings this suggest development new therapeutic approaches based CS-EO, could be applicable pharmaceutical, cosmetic nutraceutical fields protective benefits health.

Language: Английский

---

Anticancer and antiproliferative activities of Algerian Origanum majorana L.’s essential oil on PC-3 and SKBR3 cells

Journal of Essential Oil Bearing Plants, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Nov. 12, 2024

Language: Английский

---