Asian Cardiovascular and Thoracic Annals,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Rheumatic
heart
disease
(RHD)
remains
a
persistent
public
health
challenge,
particularly
prevalent
in
developing
and
underdeveloped
regions
despite
concerted
global
eradication
efforts.
The
progressive
stage
of
RHD,
marked
by
valvular
calcification,
necessitates
the
imperative
need
to
identify
prognostic
biomarkers.
Fetuin-A,
well-known
for
its
role
as
negative
inhibitor
ectopic
is
investigated
our
study
potential
biomarker
cardiac
valve
calcification
RHD
patients.
Background:
This
study
examined
the
impact
of
lactate
accumulation,
induced
by
high-intensity
interval
training
(HIIT),
on
reducing
amyloid-beta
(Aβ)
and
tau
protein
levels
through
enhanced
mitophagy
decreased
ferroptosis
in
hippocampus
type
2
diabetic
rats.Methods:
Thirty-two
male
Wistar
rats
were
divided
into
four
groups:
control
(Co),
exercise
(EX),
diabetes
(DB),
with
(DB
+
EX).
Diabetes
was
DB
EX
groups
via
a
high-fat
diet
followed
streptozotocin
injection
(35
mg/kg).
The
performed
treadmill-based
HIIT,
involving
4–10
running
intervals
at
80–100%
Vmax.
Serum
hippocampal
expression
MCT2,
SIRT1,
BDNF,
p62,
Keap1,
NRF2,
MDA,
GPX4,
PINK1,
parkin,
Aβ,
Tau
assessed.Results:
In
group,
Parkin
elevated,
while
reduced
compared
to
group.Conclusion:
HIIT
enhances
reduces
lactate-SIRT1-BDNF
p62-Keap1-NRF2
pathways,
potentially
mitigating
Aβ
accumulation.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Abstract
The
Oxidative
Balance
Score
(OBS)
serves
as
a
comprehensive
metric
that
amalgamates
17
dietary
and
lifestyle
elements
to
evaluate
antioxidant
status.
Thi
research
aims
investigate
the
association
between
OBS
prevalence
of
chronic
kidney
disease
(CKD)
in
individuals
diagnosed
with
type
2
diabetes
mellitus
(T2DM).
This
cross-sectional
study
included
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
2007
2018.
CKD
was
determined
using
albumin-to-creatinine
ratio(ACR)and
estimated
glomerular
filtration
rate
(eGFR).
Patients
were
grouped
into
low,
moderate,
high-risk
categories
based
on
their
risk
levels.
variable
transformed
continuous
format
quartiles
for
subsequent
analysis.
Weighted
multivariable
logistic
regression
restricted
cubic
spline
models
employed
examine
relationship.
Subgroup
analyses
interaction
tests
assessed
findings'
robustness.
results
indicated
negative
correlation
risk.
Individuals
higher
exhibited
decreased
(OR
0.69,
95%
CI:
0.57–0.85,
P
=
0.0003).
A
notable
identified
among
low-risk
moderate-risk
groups.
subgroup
analysis
stable,
no
significant
interactions
detected
subgroups.
Increased
levels
correlated
CKD.
Improving
capacity
through
modifications
enhance
may
serve
an
effective
strategy
prevention.
Drug and Alcohol Dependence Reports,
Journal Year:
2025,
Volume and Issue:
14, P. 100320 - 100320
Published: Feb. 6, 2025
This
study
examines
if
high-intensity
interval
training
(HIIT)
can
reduce
ethanol-induced
kidney
damage
by
modulating
cytokines
and
reducing
oxidative
stress.
Thirty
male
Wistar
rats
were
randomly
assigned
to
five
groups
(n
=
6):
CON
(saline
control),
ET
(ethanol;
3
mg/kg
of
20
%
ethanol
gavage),
HIIT
(8
weeks
HIIT),
HIIT-SL
+
HIIT-ET
(ethanol
HIIT).
Kidney
tissues
collected
for
biochemical
analysis
cytokines,
including
tumor
necrosis
factor-alpha
(TNF-α),
interleukin-6
(IL-6),
interleukin-10
(IL-10);
stress
markers,
malondialdehyde
(MDA);
antioxidants,
total
antioxidant
capacity
(TAC),
glutathione
peroxidase
(GPx),
superoxide
dismutase
(SOD).
Histopathology
serum
levels
albumin,
urea,
creatinine
evaluated.
Statistical
significance
was
assessed
using
GraphPad
Prism
(p
<
0.05).
Chronic
consumption
increased
pro-inflammatory
TNF-α
IL-6
0.0001)
decreased
anti-inflammatory
IL-10
0.0001).
revealed
tubular
necrosis,
hyaline
casts.
reduced
while
increasing
0.0001),
showing
an
effect.
The
group
had
fewer
casts
less
compared
the
group,
although
hyperemia
persisted.
improved
(TAC,
GPx,
SOD)
(MDA)
Serum
urea
higher
in
but
lower
group;
albumin
with
HIIT.
shows
effectively
reduces
ET-induced
decreasing
inflammation,
suggesting
it
as
a
promising
non-drug
approach
manage
ET-related
renal
issues.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1205 - 1205
Published: Sept. 25, 2024
Exercise
can
regulate
the
immune
function,
activate
activity
of
cells,
and
promote
health
organism,
but
mechanism
is
not
clear.
Skeletal
muscle
a
secretory
organ
that
secretes
bioactive
substances
known
as
myokines.
promotes
skeletal
contraction
expression
myokines
including
irisin,
IL-6,
BDNF,
etc.
Here,
we
review
nine
are
regulated
by
exercise.
These
have
been
shown
to
be
associated
with
responses
proliferation,
differentiation,
maturation
cells
enhance
their
thereby
serving
improve
organism.
The
aim
this
article
effects
on
intrinsic
adaptive
immunity
important
role
exercise
plays
in
them.
It
provides
theoretical
basis
for
potential
correlation
between
factor
immunity,
well
involvement
body
immunity.
also
possibility
find
suitable
training
program
system
diseases.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 31, 2024
The
oxidative
balance
score
(OBS)
is
a
comprehensive
concept
that
includes
20
stressors
and
can
be
used
to
assess
individual
pro-oxidant
versus
antioxidant
exposure,
the
aim
of
present
study
was
investigate
association
between
OBS
risk
diabetic
kidney
disease
(DKD),
low
estimated
glomerular
filtration
rate
(low-eGFR)
albuminuria
in
patients
with
diabetes
mellitus
(DM).
Behavioral and Brain Functions,
Journal Year:
2024,
Volume and Issue:
20(1)
Published: May 3, 2024
In
the
present
study,
we
investigated
effect
of
high-intensity
interval
training
(HIIT)
on
cognitive
behaviors
in
female
rats
with
a
high-fat
diet
+
streptozotocin
(STZ)-induced
type
2
diabetes.
European Journal of Sport Science,
Journal Year:
2024,
Volume and Issue:
24(7), P. 899 - 906
Published: June 14, 2024
This
study
was
conducted
to
investigate
the
effects
of
12
weeks
aerobic
exercise
(AT)
and
saffron
supplementation
on
hemostasis,
inflammatory
markers,
insulin
resistance
in
obese
women
diagnosed
with
type
2
diabetes
(T2D).
A
total
44
T2D
(mean
age:
54.12
±
5.63
years,
mean
BMI:
31.15
1.50
kg/m
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(15), P. e34917 - e34917
Published: July 20, 2024
BackgroundThis
study
aimed
to
investigate
the
effect
of
eight
weeks
high-intensity
interval
training
(HIIT)
on
muscle
metabolism
in
rats
with
type
2
diabetes
(T2D)
using
metabolomics
approaches.Methods20
male
Wistar
at
age
8
weeks-were
assigned
four
groups
five,
each
group
randomly:
control
(CTL),
(DB),
HIIT
(EX),
and
+
(DBX).
T2D
was
induced
by
two
months
a
high-fat
diet
plus
single
dose
streptozotocin
(35
mg/kg).
Rats
EX
DBX
performed
(running
80–100
%
Vmax,
4–10
intervals).
NMR
spectroscopy
used
determine
changes
metabolome
profile
after
training.ResultsChanges
metabolite
abundance
following
exercise
revealed
distinct
clustering
multivariate
analysis.
The
essential
between
DB
CTL
were
arginine
metabolism,
purine
phosphate
pathway,
amino
sugar
glutathione
aminoacyl-tRNA
biosynthesis.
However,
Arginine
biosynthesis,
pyrimidine
alanine,
aspartate,
glutamate
altered
groups.ConclusionThese
results
suggest
that
could
reverse
metabolic
rat
muscles,
contributing
reduced
FBG
HOMA-IR
levels.
