Exploring the role of vault complex in the nervous system: a literature review DOI
Arian Daneshpour, Ali Rezvanimehr,

Pegah Niktalab

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Abstract Vault RNAs (vtRNAs) are a novel group of non-coding that involved in various signaling mechanisms. vtRNAs joined by three proteins major vault protein (MVP), poly (ADP-ribose) polymerase (VPARP), and telomerase-associated 1 (TEP1) to form the complex. In humans, only four vtRNA including 1-1, 1-2, 1-3, 2-1) have been discovered. nerve cells, is synapse formation through MAPK signaling. travels distal area neurites as key unit Moreover, tRNA detached from complex neurite via mitotic kinase Aurora-A–reliant MVP phosphorylation. Several molecules contribute vtRNAs. For instance, SRSF2 NSUN2 their attachment vtRNA1-1 determines production small-vtRNAs. Through same factors, could play role neurodevelopmental deficits. Addition expression has recently studied neurodegenerative disorders such Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), amyotrophic lateral (ALS) well brain cancers. While mechanisms involvement neurological not well-demonstrated, we believe this be related impact regulation autophagy, immunoregulation, RNA stability, cellular stress, apoptosis, other epigenetic pathways. The present review captures state-of-the-art regarding neurodevelopment, normal nervous system function, disorders.

Language: Английский

Advancing personalized immunotherapy for melanoma: Integrating immunoinformatics in multi-epitope vaccine development, neoantigen identification via NGS, and immune simulation evaluation DOI
Mohammad Javad Kamali, Mohammad Salehi, Mohsen Karami Fath

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 188, P. 109885 - 109885

Published: Feb. 25, 2025

Language: Английский

Citations

2
Optimizing Si─O Conjugation to Enhance Interfacial Kinetics for Low‐Temperature Rechargeable Lithium‐Ion Batteries DOI
Yiwen Wang, Jie Liu, Haoqing Ji

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract With the growing demand for high‐voltage and wide‐temperature range applications of lithium‐ion batteries (LIBs), requirements electrolytes have become increasingly stringent. While fluorination engineering has enhanced performance traditional solvent systems, it also raised concerns regarding cost, environmental hazards, low reduction stability. Through strategic molecular bond design, a novel class low‐temperature (LT) solvents—siloxanes—is identified, meeting demands LT in LIBs. The d‐p conjugation Si─O enhances voltage resistance weakens Li + ‐solvent interactions. By modulating number conjugated bonds, type anion clusters solvation structure can be controlled, ultimately leading to formation LiF Si─O‐rich interfacial layer facilitating rapid conduction. Consequently, graphite||NCM811 pouch cell (2.3 Ah, 4.45 V) with siloxane‐based electrolyte retains 75.1% room temperature capacity (RTC) at −50 °C. interface kinetics allow superior reversible charging retention 67.6% −40 °C, good cycle stability −20 This study provides new insights into design fortify LIB harsh conditions.

Language: Английский

Citations

10
Biological significance and pathophysiological role of Matrix Metalloproteinases in the Central Nervous System DOI
Krishnendu Ganguly, Krishnendu Adhikary, Arup Acharjee

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135967 - 135967

Published: Sept. 1, 2024

Language: Английский

Citations

6
Designing of an efficient DC-inducing multi-epitope vaccine against Epstein Barr virus targeting the GP350 using immunoinformatics and molecular dynamic simulation DOI

Golzar Fatahi,

Mohammad Reza Abdollahi, Zahra Nashtahosseini

et al.

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 42, P. 101966 - 101966

Published: March 3, 2025

Language: Английский

Citations

0
COVID-19 infection in inborn errors of immunity and their phenocopies: a systematic review and meta-analysis DOI
Saba Fekrvand, Kiarash Saleki,

Hassan Abolhassani

et al.

Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 35

Published: April 3, 2025

Inborn errors of immunity (IEI) are congenital disorders the immune system. Due to impaired system, they at a higher risk develop more severe COVID-19 course compared general population. Herein, we aimed systematically review various aspects IEI patients infected with SARS-CoV-2. Moreover, performed meta-analysis determine frequency in different IEI. Embase, Web Science, PubMed, and Scopus were searched introducing terms related COVID-19. 3646 cases history infection enrolled. The majority had critical infections (1013 cases, 27.8%). highest was observed phenocopies (95.2%), defects intrinsic innate (69.4%) dysregulation (23.9%). 446 (12.2%) succumbed disease mortality (34.6%). immunodeficient 11.9% (95% CI: 8.3 15.5%) immunodeficiency having [34.1% (12.1 56.0%)]. case fatality rate among estimated as 5.4% 3.5-8.3%, n = 8 studies, I2 17.5%). underlying specific branches system responding RNA virus experience infection. Increasing awareness about these entities genetic defects, adherence prophylactic strategies allocating clinical attention could lead decrease patients.

Language: Английский

Citations

0
Neuropilin‐1 as a Neuroinflammatory Entry Factor for SARS‐CoV‐2 Is Attenuated in Vaccinated COVID‐19 Patients: A Case–Control Study DOI Creative Commons
Faezeh Sadat Hosseini, Abbas Azadmehr, Kiarash Saleki

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(4)

Published: April 1, 2025

ABSTRACT Background and Aim COVID‐19 is caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) as a pandemic infectious disease. So far, it has been known that this virus uses several receptors to enter the host cell, one of which neuropilin‐1 (NRP1). Also, main causes clinical manifestations, severity disease, mortality patients cytokine storm syndrome, these cytokines being interleukin (IL)‐6. Our aim was study level expression NRP1 IL‐6 genes in using peripheral blood mononuclear cells (PBMCs). Materials Methods population included test group (80 with COVID‐19) control (30 healthy individuals). Venous taken from all subjects. After isolating PBMCs Ficoll, RNA extracted. Then, cDNA synthesis, compared GAPDH housekeeping gene measured real‐time PCR. Results The increased significantly different groups group. Surprisingly, observed amount decreased vaccinated nonvaccinated groups. also except results indicated there positive statistically considerable relationship between ( p = 0.03). Conclusion significant increase patients, especially moderate cases, indicates their potential involvement progression may serve biomarkers disease severity. since play an important role causing inflammation, storm, immunopathological complications COVID‐19, further investigations maybe needed achieve therapeutic goals similar diseases.

Language: Английский

Citations

0
The drug discovery candidate for targeting PARP1 with Onosma. Dichroantha compounds in Triple-negative breast cancer: A Virtual screening and Molecular Dynamic Simulation DOI
Mohamed J. Saadh,

Hanan Hassan Ahmed,

Radhwan Abdul Kareem

et al.

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108471 - 108471

Published: April 1, 2025

Language: Английский

Citations

0
HIF-1α Pathway in COVID-19: A Scoping Review of Its Modulation and Related Treatments DOI Open Access
Felipe Silva,

R Matte,

David Batista Wiedmer

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4202 - 4202

Published: April 28, 2025

The COVID-19 pandemic, driven by SARS-CoV-2, has led to a global health crisis, highlighting the virus’s unique molecular mechanisms that distinguish it from other respiratory pathogens. It is known Hypoxia-Inducible Factor 1α (HIF-1α) activates complex network of intracellular signaling pathways regulating cellular energy metabolism, angiogenesis, and cell survival, contributing wide range clinical manifestations COVID-19, including Post-Acute Syndrome (PACS). Emerging evidence suggests dysregulation HIF-1α key driver systemic inflammation, silent hypoxia, pathological tissue remodeling in both acute post-acute phases disease. This scoping review was conducted following PRISMA-ScR guidelines registered INPLASY. involved literature search Scopus PubMed, supplemented manual reference screening, with study selection facilitated Rayyan software. Our analysis clarifies dual role HIF-1α, which may either worsen inflammatory responses viral persistence or support adaptive reduce damage. potential for targeting therapeutically complex, requiring further investigation clarify its precise translational applications. deepens understanding SARS-CoV-2-induced dysfunction offering insights improving management strategies addressing long-term sequelae.

Language: Английский

Citations

0
Is neuropilin-1 the neuroimmune initiator of multi-system hyperinflammation in COVID-19? DOI Open Access
Kiarash Saleki,

Parsa Alijanizadeh,

Abbas Azadmehr

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115558 - 115558

Published: Sept. 23, 2023

A major immunopathological feature of Coronavirus disease-2019 (COVID-19) is excessive inflammation in the form "cytokine storm". The storm characterized by injurious levels cytokines which a complicated network damaging different organs, including lungs and brain. main starter network" hyperactivation COVID-19 has not been discovered yet. Neuropilins (NRPs) are transmembrane proteins that act as neuronal guidance angiogenesis modulators. crucial function NRPs forming nervous vascular systems well-studied. NRP1 NRP2 two identified homologs NRP. shown viral entry pathway for SARS-CoV2, facilitates neuroinvasion virus within central or peripheral systems. These molecules directly interact with various COVID-19-related molecules, such specific regions spike protein (major immune element SARS-CoV2), endothelial growth factor (VEGF) receptors, VEGFR1/2, ANGPTL4 (regulator vessel permeability integrity). mainly play role hyperinflammatory injury CNS lungs, also liver, kidney, pancreas, heart patients. New findings have suggested good candidates pharmacotherapy COVID-19. However, therapeutic targeting still preclinical phase. This review presents implications multi-organ inflammation-induced SARS-CoV2 provides insights NRP1-targeting treatments

Language: Английский

Citations

9
Nanocarriers in glioblastoma treatment: a neuroimmunological perspective DOI
Faezeh Firuzpour, Kiarash Saleki, Cena Aram

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Glioblastoma multiforme (GBM) is the most fatal brain tumor with a poor prognosis current treatments, mainly because of intrinsic resistance processes. GBM also referred to as grade 4 astrocytoma, that makes up about 15.4 % cancers globally well 60-75 astrocytoma. The prevalent therapeutic choices for comprise surgery in combination radiotherapy and chemotherapy, providing patients an average survival 6-14 months. Nanocarriers provide various benefits such enhanced drug solubility, biocompatibility, targeted activity, minimized side effects. In addition, treatment comes several challenges presence blood-brain barrier (BBB), (BBTB), overexpressed efflux pumps, infiltration, invasion, resistance, immune escape due microenvironment (TME) cancer stem cells (CSC). Recent research has focused on nanocarriers their ability self-assemble, improve bioavailability, controlled release, penetrate BBB. These nano-based components could potentially enhance accumulation tissues reduce systemic toxicity, making them compelling solution therapy. This review captures complexities associated multi-functional nano delivery systems (NDDS) crossing (BBB) targeting cells. it presents succinct overview types system which exhibited promising value improving brain.

Language: Английский

Citations

2